Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.
Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Hist...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4537248?pdf=render |
| _version_ | 1819278035776438272 |
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| author | Miguel A Ortiz Concepción Núñez David Ordóñez José C Alvarez-Cermeño José E Martínez-Rodriguez Antonio J Sánchez Rafael Arroyo Guillermo Izquierdo Sunny Malhotra Xavier Montalban Antonio García-Merino Elvira Munteis Antonio Alcina Manuel Comabella Fuencisla Matesanz Luisa M Villar Elena Urcelay |
| author_facet | Miguel A Ortiz Concepción Núñez David Ordóñez José C Alvarez-Cermeño José E Martínez-Rodriguez Antonio J Sánchez Rafael Arroyo Guillermo Izquierdo Sunny Malhotra Xavier Montalban Antonio García-Merino Elvira Munteis Antonio Alcina Manuel Comabella Fuencisla Matesanz Luisa M Villar Elena Urcelay |
| author_sort | Miguel A Ortiz |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results.In an attempt to shed some light on these controversial findings, a combined analysis was performed including the previously published datasets and three newly genotyped cohorts. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities.Overall, this meta-analysis involved 3200 MS patients and 3069 matched healthy controls and it did not evidence significant association of the LILRA3 deletion [carriers of LILRA3 deletion: p = 0.25, OR (95% CI) = 1.07 (0.95-1.19)], even after stratification by gender and the HLA-DRB1*15:01 risk allele. |
| first_indexed | 2024-12-24T00:05:37Z |
| format | Article |
| id | doaj.art-71212e472792411cbda73856ca44fc86 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-24T00:05:37Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-71212e472792411cbda73856ca44fc862022-12-21T17:25:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013441410.1371/journal.pone.0134414Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.Miguel A OrtizConcepción NúñezDavid OrdóñezJosé C Alvarez-CermeñoJosé E Martínez-RodriguezAntonio J SánchezRafael ArroyoGuillermo IzquierdoSunny MalhotraXavier MontalbanAntonio García-MerinoElvira MunteisAntonio AlcinaManuel ComabellaFuencisla MatesanzLuisa M VillarElena UrcelayMultiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results.In an attempt to shed some light on these controversial findings, a combined analysis was performed including the previously published datasets and three newly genotyped cohorts. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities.Overall, this meta-analysis involved 3200 MS patients and 3069 matched healthy controls and it did not evidence significant association of the LILRA3 deletion [carriers of LILRA3 deletion: p = 0.25, OR (95% CI) = 1.07 (0.95-1.19)], even after stratification by gender and the HLA-DRB1*15:01 risk allele.http://europepmc.org/articles/PMC4537248?pdf=render |
| spellingShingle | Miguel A Ortiz Concepción Núñez David Ordóñez José C Alvarez-Cermeño José E Martínez-Rodriguez Antonio J Sánchez Rafael Arroyo Guillermo Izquierdo Sunny Malhotra Xavier Montalban Antonio García-Merino Elvira Munteis Antonio Alcina Manuel Comabella Fuencisla Matesanz Luisa M Villar Elena Urcelay Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis. PLoS ONE |
| title | Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis. |
| title_full | Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis. |
| title_fullStr | Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis. |
| title_full_unstemmed | Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis. |
| title_short | Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis. |
| title_sort | influence of the lilra3 deletion on multiple sclerosis risk original data and meta analysis |
| url | http://europepmc.org/articles/PMC4537248?pdf=render |
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