Blocking CHK1 Expression Induces Apoptosis and Abrogates the G2 Checkpoint Mechanism

Blocking CHK1 Expression Induces Apoptosis and Abrogates the G2 Checkpoint Mechanism

Checkpoint kinase 1 (Chki) is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates the Cdc2 activating phosphatase Cdc25C. This in turn inactivates Cdc2, which leads to G2/M arrest. We report that blocking Chki expression by antisense or ribozymes in mammalian cell...

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Dades bibliogràfiques
Autors principals: Yan Luo, Shayna K. Rockow-Magnone, Paul E. Kroeger, Leigh Frost, Zehan Chen, Edward K.-H. Han, Shi-Chung Ng, Robert L. Simmer, Vincent L. Giranda
Format: Article
Idioma:English
Publicat: Elsevier 2001-01-01
Col·lecció:Neoplasia: An International Journal for Oncology Research
Matèries:
Chk1
antisense
ribozyme
checkpoint
chemotherapy sensitization
Accés en línia:http://www.sciencedirect.com/science/article/pii/S1476558601800543

Internet

http://www.sciencedirect.com/science/article/pii/S1476558601800543

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