The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practice
Introduction: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) plays a key role in oncology, and it is now being used increasingly to diagnose, characterize, and monitor disease activity in inflammatory disorders, including vasculitis. Unfortunately, its rol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2012-01-01
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| Series: | Italian Journal of Medicine |
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| Online Access: | http://www.italjmed.org/index.php/ijm/article/view/111 |
| _version_ | 1797431149852622848 |
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| author | Maria V. Mattoli Giorgio Treglia Lucia Leccisotti Alessandro Giordano |
| author_facet | Maria V. Mattoli Giorgio Treglia Lucia Leccisotti Alessandro Giordano |
| author_sort | Maria V. Mattoli |
| collection | DOAJ |
| description | Introduction: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) plays a key role in oncology, and it is now being used increasingly to diagnose, characterize, and monitor disease activity in inflammatory disorders, including vasculitis. Unfortunately, its role in the management of vasculitis is still not well-defined, and clinicians are often unsure how this metabolic imaging technique should be used in these diseases, although its usefulness in diagnosing large-vessel vasculitis has been clearly demonstrated. <br />Materials and methods: We reviewed the literature about the use of PET/CT in the management of vasculitis in an attempt to identify the applications and the limitations of this technique in clinical practice. <br />Results and discussion: Our literature review revealed that 18F-FDG PET/CT is a useful tool for diagnosing vasculitis (especially when the symptoms of the disease are non-specific); guiding biopsy procedures (areas with high glucose consumption); evaluating disease extension; and monitoring treatment responses. The main limitations of this method are the relatively low spatial resolution of the tomograph, which can lead to false-negative results in the presence of small-vessel vasculitis, and risk of false positive results, especially those related to the presence of atherosclerosis and to post-treatment vascular remodeling. |
| first_indexed | 2024-03-09T09:38:51Z |
| format | Article |
| id | doaj.art-712509a584284b9792ffcc71c0ef7617 |
| institution | Directory Open Access Journal |
| issn | 1877-9344 1877-9352 |
| language | English |
| last_indexed | 2024-03-09T09:38:51Z |
| publishDate | 2012-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj.art-712509a584284b9792ffcc71c0ef76172023-12-02T01:05:24ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522012-01-015424925410.4081/itjm.2011.24985The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practiceMaria V. MattoliGiorgio TregliaLucia LeccisottiAlessandro GiordanoIntroduction: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) plays a key role in oncology, and it is now being used increasingly to diagnose, characterize, and monitor disease activity in inflammatory disorders, including vasculitis. Unfortunately, its role in the management of vasculitis is still not well-defined, and clinicians are often unsure how this metabolic imaging technique should be used in these diseases, although its usefulness in diagnosing large-vessel vasculitis has been clearly demonstrated. <br />Materials and methods: We reviewed the literature about the use of PET/CT in the management of vasculitis in an attempt to identify the applications and the limitations of this technique in clinical practice. <br />Results and discussion: Our literature review revealed that 18F-FDG PET/CT is a useful tool for diagnosing vasculitis (especially when the symptoms of the disease are non-specific); guiding biopsy procedures (areas with high glucose consumption); evaluating disease extension; and monitoring treatment responses. The main limitations of this method are the relatively low spatial resolution of the tomograph, which can lead to false-negative results in the presence of small-vessel vasculitis, and risk of false positive results, especially those related to the presence of atherosclerosis and to post-treatment vascular remodeling.http://www.italjmed.org/index.php/ijm/article/view/111VasculitisFDGPETPET/CT. |
| spellingShingle | Maria V. Mattoli Giorgio Treglia Lucia Leccisotti Alessandro Giordano The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practice Italian Journal of Medicine Vasculitis FDG PET PET/CT. |
| title | The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practice |
| title_full | The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practice |
| title_fullStr | The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practice |
| title_full_unstemmed | The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practice |
| title_short | The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practice |
| title_sort | role of 18f fdg pet ct in the management of large vessel vasculitis applications and limitations in clinical practice |
| topic | Vasculitis FDG PET PET/CT. |
| url | http://www.italjmed.org/index.php/ijm/article/view/111 |
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