Metabolism of lipid in the human fatty streak lesion
The composition and synthesis of lipid have been examined in normal intima and adjacent fatty streak lesions of human arterial segments which were incubated with [2-14C]acetate. The incorporation of acetate into lipid was greater in fatty streaks than in normal intima. There was increased acetate in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
1972-03-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752039413X |
| _version_ | 1818596195324395520 |
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| author | Aram V. Chobanian Francisco Manzur |
| author_facet | Aram V. Chobanian Francisco Manzur |
| author_sort | Aram V. Chobanian |
| collection | DOAJ |
| description | The composition and synthesis of lipid have been examined in normal intima and adjacent fatty streak lesions of human arterial segments which were incubated with [2-14C]acetate. The incorporation of acetate into lipid was greater in fatty streaks than in normal intima. There was increased acetate incorporation into all major lipid groups in the fatty streak, with the greatest relative increase in the cholesteryl ester fraction. The major radiolabeled arterial fatty acid was a long-chain polyenoic fatty acid with chromatographic properties of a C22:4 acid. The content of fatty acid in the fatty streaks differed from that in normal intima, with substantial increases in the C18:l acid and decreases in C16:0, C18:0, and C18:2 acids of the fatty streak. It is concluded that lipid synthesis is increased in the human fatty streak lesion and that the local metabolism of lipid contributes to its accumulation within the fatty streak. |
| first_indexed | 2024-12-16T11:28:03Z |
| format | Article |
| id | doaj.art-712564579e184c24ae62ad35415bc8d1 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T11:28:03Z |
| publishDate | 1972-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-712564579e184c24ae62ad35415bc8d12022-12-21T22:33:19ZengElsevierJournal of Lipid Research0022-22751972-03-01132201206Metabolism of lipid in the human fatty streak lesionAram V. Chobanian0Francisco Manzur1Department of Medicine, Boston University School of Medicine, and Boston City Hospital, Boston, Massachusetts 02118Department of Medicine, Boston University School of Medicine, and Boston City Hospital, Boston, Massachusetts 02118The composition and synthesis of lipid have been examined in normal intima and adjacent fatty streak lesions of human arterial segments which were incubated with [2-14C]acetate. The incorporation of acetate into lipid was greater in fatty streaks than in normal intima. There was increased acetate incorporation into all major lipid groups in the fatty streak, with the greatest relative increase in the cholesteryl ester fraction. The major radiolabeled arterial fatty acid was a long-chain polyenoic fatty acid with chromatographic properties of a C22:4 acid. The content of fatty acid in the fatty streaks differed from that in normal intima, with substantial increases in the C18:l acid and decreases in C16:0, C18:0, and C18:2 acids of the fatty streak. It is concluded that lipid synthesis is increased in the human fatty streak lesion and that the local metabolism of lipid contributes to its accumulation within the fatty streak.http://www.sciencedirect.com/science/article/pii/S002222752039413Xarterial lipid metabolismhuman arterial metabolismatherosclerosis |
| spellingShingle | Aram V. Chobanian Francisco Manzur Metabolism of lipid in the human fatty streak lesion Journal of Lipid Research arterial lipid metabolism human arterial metabolism atherosclerosis |
| title | Metabolism of lipid in the human fatty streak lesion |
| title_full | Metabolism of lipid in the human fatty streak lesion |
| title_fullStr | Metabolism of lipid in the human fatty streak lesion |
| title_full_unstemmed | Metabolism of lipid in the human fatty streak lesion |
| title_short | Metabolism of lipid in the human fatty streak lesion |
| title_sort | metabolism of lipid in the human fatty streak lesion |
| topic | arterial lipid metabolism human arterial metabolism atherosclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S002222752039413X |
| work_keys_str_mv | AT aramvchobanian metabolismoflipidinthehumanfattystreaklesion AT franciscomanzur metabolismoflipidinthehumanfattystreaklesion |