Predictive toxicogenomics for cancer risk assessment
<p><strong>Abstract:</strong> Every organism, and therefore also humans, is the product of its genes in combination with its environment. The activity of genes is strictly regulated and is continuously liable to changes. The response of an organism to changes in its environment, su...
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2007-12-01
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| Series: | Zdravniški Vestnik |
| Subjects: | |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/1978 |
| _version_ | 1818505660527017984 |
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| author | Joost H. M. van Delft Jos C.S. Kleinjans |
| author_facet | Joost H. M. van Delft Jos C.S. Kleinjans |
| author_sort | Joost H. M. van Delft |
| collection | DOAJ |
| description | <p><strong>Abstract:</strong> Every organism, and therefore also humans, is the product of its genes in combination with its environment. The activity of genes is strictly regulated and is continuously liable to changes. The response of an organism to changes in its environment, such as the exposure to a toxic substance, leads to altered gene expressions. Analysing modified gene expression profiles as a result of exposure to chemical substances, can therefore aid to determine the hazardous properties of those substances, such as on carcinogenic capacity. This toxicogenomics approach also provides the possibility to drastically reduce the traditional animal tests.</p> |
| first_indexed | 2024-12-10T21:53:54Z |
| format | Article |
| id | doaj.art-712580d4052d4105b3d84160a77bb42e |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-10T21:53:54Z |
| publishDate | 2007-12-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-712580d4052d4105b3d84160a77bb42e2022-12-22T01:32:07ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242007-12-017601495Predictive toxicogenomics for cancer risk assessmentJoost H. M. van DelftJos C.S. Kleinjans<p><strong>Abstract:</strong> Every organism, and therefore also humans, is the product of its genes in combination with its environment. The activity of genes is strictly regulated and is continuously liable to changes. The response of an organism to changes in its environment, such as the exposure to a toxic substance, leads to altered gene expressions. Analysing modified gene expression profiles as a result of exposure to chemical substances, can therefore aid to determine the hazardous properties of those substances, such as on carcinogenic capacity. This toxicogenomics approach also provides the possibility to drastically reduce the traditional animal tests.</p>http://vestnik.szd.si/index.php/ZdravVest/article/view/1978risk assessmentcancertoxicogenomics |
| spellingShingle | Joost H. M. van Delft Jos C.S. Kleinjans Predictive toxicogenomics for cancer risk assessment Zdravniški Vestnik risk assessment cancer toxicogenomics |
| title | Predictive toxicogenomics for cancer risk assessment |
| title_full | Predictive toxicogenomics for cancer risk assessment |
| title_fullStr | Predictive toxicogenomics for cancer risk assessment |
| title_full_unstemmed | Predictive toxicogenomics for cancer risk assessment |
| title_short | Predictive toxicogenomics for cancer risk assessment |
| title_sort | predictive toxicogenomics for cancer risk assessment |
| topic | risk assessment cancer toxicogenomics |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/1978 |
| work_keys_str_mv | AT joosthmvandelft predictivetoxicogenomicsforcancerriskassessment AT joscskleinjans predictivetoxicogenomicsforcancerriskassessment |