Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interest
Abstract Background The use of new total joint arthroplasty technologies, including patient-specific implants/instrumentation (PSI), computer-assisted (CA), and robotic-assisted (RA) techniques, is increasing. There is an ongoing debate regarding the value provided and potential concerns about confl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Arthroplasty |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42836-022-00146-3 |
| _version_ | 1797984674167914496 |
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| author | Garrhett G. Via David A. Brueggeman Joseph G. Lyons Isabelle C. Ely Andrew W. Froehle Anil B. Krishnamurthy |
| author_facet | Garrhett G. Via David A. Brueggeman Joseph G. Lyons Isabelle C. Ely Andrew W. Froehle Anil B. Krishnamurthy |
| author_sort | Garrhett G. Via |
| collection | DOAJ |
| description | Abstract Background The use of new total joint arthroplasty technologies, including patient-specific implants/instrumentation (PSI), computer-assisted (CA), and robotic-assisted (RA) techniques, is increasing. There is an ongoing debate regarding the value provided and potential concerns about conflicts of interest (COI). Methods PRISMA guidelines were followed. PubMed, MEDLINE, and Web of Science databases were searched for total hip and knee arthroplasties, unicompartmental knee arthroplasties (UKA), PSI, CA, and RA. Bibliometric data, financial COI, clinical/functional scores, and patient-reported outcomes were assessed. Results Eighty-seven studies were evaluated, with 35 (40.2%) including at least one author reporting COI, and 13 (14.9%) disclosing industry funding. COI and industry funding had no significant effects on outcomes (P = 0.682, P = 0.447), and there were no significant effects of conflicts or funding on level of evidence (P = 0.508, P = 0.826). Studies in which author(s) disclosed COI had significantly higher relative citation ratio (RCR) and impact factor (IF) than those without (P < 0.001, P = 0.032). Subanalysis demonstrated RA and PSI studies were more likely to report COI or industry funding (P = 0.045). RA (OR = 6.31, 95% CI: 1.61–24.68) and UKA (OR = 9.14, 95% CI: 1.43–58.53) had higher odds of reporting favorable outcomes than PSI. Conclusions Author COIs (about 40%) may be lower than previously reported in orthopedic technologies/techniques reviews. Studies utilizing RA and PSI were more likely to report COI, while RA and UKA studies were more likely to report favorable outcomes than PSI. No statistically significant association between the presence of COIs and/or industry funding and the frequency of favorable outcomes or study level of evidence was found. Level of evidence Level V Systematic Review |
| first_indexed | 2024-04-11T07:05:45Z |
| format | Article |
| id | doaj.art-71259bcc7d4e44a4804a48b24b939273 |
| institution | Directory Open Access Journal |
| issn | 2524-7948 |
| language | English |
| last_indexed | 2024-04-11T07:05:45Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthroplasty |
| spelling | doaj.art-71259bcc7d4e44a4804a48b24b9392732022-12-22T04:38:23ZengBMCArthroplasty2524-79482022-11-014111110.1186/s42836-022-00146-3Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interestGarrhett G. Via0David A. Brueggeman1Joseph G. Lyons2Isabelle C. Ely3Andrew W. Froehle4Anil B. Krishnamurthy5Department of Orthopedic Surgery, Wright State UniversityDepartment of Orthopedic Surgery, Wright State UniversityDepartment of Orthopedic Surgery, Wright State UniversityDepartment of Orthopedic Surgery, Wright State UniversityDepartment of Orthopedic Surgery, Wright State UniversityDepartment of Orthopedic Surgery, Wright State UniversityAbstract Background The use of new total joint arthroplasty technologies, including patient-specific implants/instrumentation (PSI), computer-assisted (CA), and robotic-assisted (RA) techniques, is increasing. There is an ongoing debate regarding the value provided and potential concerns about conflicts of interest (COI). Methods PRISMA guidelines were followed. PubMed, MEDLINE, and Web of Science databases were searched for total hip and knee arthroplasties, unicompartmental knee arthroplasties (UKA), PSI, CA, and RA. Bibliometric data, financial COI, clinical/functional scores, and patient-reported outcomes were assessed. Results Eighty-seven studies were evaluated, with 35 (40.2%) including at least one author reporting COI, and 13 (14.9%) disclosing industry funding. COI and industry funding had no significant effects on outcomes (P = 0.682, P = 0.447), and there were no significant effects of conflicts or funding on level of evidence (P = 0.508, P = 0.826). Studies in which author(s) disclosed COI had significantly higher relative citation ratio (RCR) and impact factor (IF) than those without (P < 0.001, P = 0.032). Subanalysis demonstrated RA and PSI studies were more likely to report COI or industry funding (P = 0.045). RA (OR = 6.31, 95% CI: 1.61–24.68) and UKA (OR = 9.14, 95% CI: 1.43–58.53) had higher odds of reporting favorable outcomes than PSI. Conclusions Author COIs (about 40%) may be lower than previously reported in orthopedic technologies/techniques reviews. Studies utilizing RA and PSI were more likely to report COI, while RA and UKA studies were more likely to report favorable outcomes than PSI. No statistically significant association between the presence of COIs and/or industry funding and the frequency of favorable outcomes or study level of evidence was found. Level of evidence Level V Systematic Reviewhttps://doi.org/10.1186/s42836-022-00146-3Conflict of interestFundingTotal joint arthroplastyRobotic-assistedComputer-navigatedPatient-specific implant |
| spellingShingle | Garrhett G. Via David A. Brueggeman Joseph G. Lyons Isabelle C. Ely Andrew W. Froehle Anil B. Krishnamurthy Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interest Arthroplasty Conflict of interest Funding Total joint arthroplasty Robotic-assisted Computer-navigated Patient-specific implant |
| title | Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interest |
| title_full | Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interest |
| title_fullStr | Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interest |
| title_full_unstemmed | Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interest |
| title_short | Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interest |
| title_sort | funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies a systematic review of bibliometrics and conflicts of interest |
| topic | Conflict of interest Funding Total joint arthroplasty Robotic-assisted Computer-navigated Patient-specific implant |
| url | https://doi.org/10.1186/s42836-022-00146-3 |
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