Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control Study
Recent evidence has suggested that the gut microbiota is a possible risk factor for obesity. However, limited evidence is available on the association between the gut microbiota composition and obesity markers in the Middle-Eastern region. We aimed to investigate the association between gut microbio...
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MDPI AG
2022-10-01
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| Online Access: | https://www.mdpi.com/2079-7737/11/11/1586 |
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| author | Esra’a A. Aljazairy Sara Al-Musharaf Manal Abudawood Basmah Almaarik Syed D. Hussain Abdullah M. Alnaami Shaun Sabico Nasser M. Al-Daghri Mario Clerici Ghadeer S. Aljuraiban |
| author_facet | Esra’a A. Aljazairy Sara Al-Musharaf Manal Abudawood Basmah Almaarik Syed D. Hussain Abdullah M. Alnaami Shaun Sabico Nasser M. Al-Daghri Mario Clerici Ghadeer S. Aljuraiban |
| author_sort | Esra’a A. Aljazairy |
| collection | DOAJ |
| description | Recent evidence has suggested that the gut microbiota is a possible risk factor for obesity. However, limited evidence is available on the association between the gut microbiota composition and obesity markers in the Middle-Eastern region. We aimed to investigate the association between gut microbiota and obesity markers in a case-control study including 92 Saudi women aged 18–25 years, including participants with obesity (case, <i>n</i> = 44) and with normal weight (control, <i>n</i> = 48). Anthropometric, body composition, and biochemical data were collected. The whole-genome shotgun technique was used to analyze the gut microbiota. The Shannon alpha and Bray–Curtis beta diversity were determined. The microbial alpha diversity was significantly associated with only the waist-to-hip ratio (WHR) (<i>p</i>-value = 0.04), while the microbial beta diversity was significantly associated with body mass index (<i>p</i>-value = 0.048), %body fat (<i>p</i>-value = 0.018), and WHR (<i>p</i>-value = 0.050). Specific bacteria at different taxonomic levels, such as Bacteroidetes and Synergistetes, were positively associated with different obesity markers. Alistipes was higher in the control group compared with the case group. The results highlight the association of the gut microbiota with obesity and suggest that the gut microbiota of Saudi women is associated with specific obesity markers. Future studies are needed to determine the role of the identified strains in the metabolism of individuals with obesity. |
| first_indexed | 2024-03-09T19:15:12Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T19:15:12Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-712649b7102e4c65b8ed35de2e8f44d52023-11-24T03:47:52ZengMDPI AGBiology2079-77372022-10-011111158610.3390/biology11111586Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control StudyEsra’a A. Aljazairy0Sara Al-Musharaf1Manal Abudawood2Basmah Almaarik3Syed D. Hussain4Abdullah M. Alnaami5Shaun Sabico6Nasser M. Al-Daghri7Mario Clerici8Ghadeer S. Aljuraiban9Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Turki Alawwal Street, Riyadh 11451, Saudi ArabiaDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Turki Alawwal Street, Riyadh 11451, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi ArabiaChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pathophysiology and Transplantation, University of Milan, 20122 Milan, ItalyDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Turki Alawwal Street, Riyadh 11451, Saudi ArabiaRecent evidence has suggested that the gut microbiota is a possible risk factor for obesity. However, limited evidence is available on the association between the gut microbiota composition and obesity markers in the Middle-Eastern region. We aimed to investigate the association between gut microbiota and obesity markers in a case-control study including 92 Saudi women aged 18–25 years, including participants with obesity (case, <i>n</i> = 44) and with normal weight (control, <i>n</i> = 48). Anthropometric, body composition, and biochemical data were collected. The whole-genome shotgun technique was used to analyze the gut microbiota. The Shannon alpha and Bray–Curtis beta diversity were determined. The microbial alpha diversity was significantly associated with only the waist-to-hip ratio (WHR) (<i>p</i>-value = 0.04), while the microbial beta diversity was significantly associated with body mass index (<i>p</i>-value = 0.048), %body fat (<i>p</i>-value = 0.018), and WHR (<i>p</i>-value = 0.050). Specific bacteria at different taxonomic levels, such as Bacteroidetes and Synergistetes, were positively associated with different obesity markers. Alistipes was higher in the control group compared with the case group. The results highlight the association of the gut microbiota with obesity and suggest that the gut microbiota of Saudi women is associated with specific obesity markers. Future studies are needed to determine the role of the identified strains in the metabolism of individuals with obesity.https://www.mdpi.com/2079-7737/11/11/1586gut microbiotaobesityBMI%body fatWHRmicrobial alpha diversity |
| spellingShingle | Esra’a A. Aljazairy Sara Al-Musharaf Manal Abudawood Basmah Almaarik Syed D. Hussain Abdullah M. Alnaami Shaun Sabico Nasser M. Al-Daghri Mario Clerici Ghadeer S. Aljuraiban Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control Study Biology gut microbiota obesity BMI %body fat WHR microbial alpha diversity |
| title | Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control Study |
| title_full | Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control Study |
| title_fullStr | Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control Study |
| title_full_unstemmed | Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control Study |
| title_short | Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control Study |
| title_sort | influence of adiposity on the gut microbiota composition of arab women a case control study |
| topic | gut microbiota obesity BMI %body fat WHR microbial alpha diversity |
| url | https://www.mdpi.com/2079-7737/11/11/1586 |
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