| Summary: | Three new cembranoids (<b>1</b>–<b>3</b>) and a new casbanoid (<b>4</b>), along with three known analogues (<b>5</b>–<b>7</b>), have been isolated from the soft coral <i>Sinularia nanolobata</i> collected off Ximao Island. The structures, including the absolute configurations of new compounds, were established using extensive spectroscopic data analysis, time-dependent density functional theory/electronic circular dichroism (TDDFT-ECD) calculations, and the comparison with spectroscopic data of known compounds. In the in vitro bioassay, compounds <b>1</b> and <b>5</b> exhibited moderate cytotoxic activities against human erythroleukemia (HEL) cell lines, with IC<sub>50</sub> values of 37.1 and 42.4 μM, respectively.
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