Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo

Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo

Nicastrin is an integral member of PS-complexes that perform γ-secretase cleavage of numerous type I membrane proteins including amyloid precursor protein that underlies Alzheimer's disease; thus, diminishing γ-secretase activity by reducing levels of functional PS-complexes is suggested as a p...

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Bibliographic Details
Main Authors: Sonya Brijbassi, Zareen Amtul, Susan Newbigging, David Westaway, Peter St George-Hyslop, Richard F. Rozmahel
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Nicastrin presenilin
γ-secretase
Amyloid precursor protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002403

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