Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction
Objective: The aim of this study was to investigate the predictive value of copeptin levels in the development of contrast-induced nephropathy (CIN). Methods: A total of 274 patients diagnosed with ST-elevation myocardial infarction (STEMI) and who had undergone primary percutaneous coronary interve...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-12-01
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| Series: | Revista Portuguesa de Cardiologia |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0870255120300330 |
| _version_ | 1818507887937323008 |
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| author | Ersin Yildirim Ayca Turer Cabbar |
| author_facet | Ersin Yildirim Ayca Turer Cabbar |
| author_sort | Ersin Yildirim |
| collection | DOAJ |
| description | Objective: The aim of this study was to investigate the predictive value of copeptin levels in the development of contrast-induced nephropathy (CIN). Methods: A total of 274 patients diagnosed with ST-elevation myocardial infarction (STEMI) and who had undergone primary percutaneous coronary intervention were included in the study. The patients were divided into two groups according to the presence (CIN+) or absence (CIN-) of CIN. These groups were compared in terms of demographic characteristics, laboratory findings and risk factors. Results: Copeptin levels (10.68±6.43 vs. 7.07±05.53 pmol/l; p<0.001) and peak creatinine (1.46±1.20 vs. 1.03±0.20 mg/dl; p=0.005) were significantly higher in the CIN+ group than in the CIN- group. Female gender was significantly more prevalent in the CIN- group compared to the CIN+ group (19% vs. 8.6%; p<0.05). Copeptin level at hospital admission (OR: 2.36, p=0.005) was found to be an independent predictor for CIN development. Conclusion: Copeptin level is an independent predictor of CIN development in patients with acute STEMI that can be detected rapidly and easily. This result indicates that physicians should be aware of the possibility of CIN development in patients with high copeptin levels and preventive measures should start early. Resumo: Objetivos: Análise do valor preditivo dos níveis de copeptina no desenvolvimento da nefropatia induzida por contraste (NIC). Métodos: Foram incluídos no estudo 274 doentes, diagnosticados com enfarte do miocárdio com elevação do segmento ST (STEMI) e submetidos a angioplastia coronária primária. Os doentes foram divididos em dois grupos de acordo com a confirmação de NIC. Estes grupos foram comparados quanto às características demográficas, achados laboratoriais e fatores de risco. Resultados: O nível de copeptina (10,68±6,43 versus 7,07±5,53; p<0,001) e o pico dos níveis de creatinina (1,46±1,20 versus 1,03±0,20; p=0,005) foram significativamente superiores nos grupos de NIC (+) quando comparados com os grupos de NIC (-). A percentagem do género feminino foi significativamente superior no grupo NIC (-) quando comparada com o grupo NIC (+) (19% versus 8,6%; p<0,05). O nível da copeptina no momento do internamento (OR: 2,36, p=0,005) foi considerado como um valor preditor independente no desenvolvimento da NIC. Conclusão: O nível da copeptina é um fator preditor independente do desenvolvimento da NIC em doentes com STEMI agudo. Pode ser detetado rápida e facilmente e este resultado indica que os médicos devem ser mais cuidadosos em relação ao desenvolvimento da NIC em doentes com níveis de copeptina levados. Medidas preventivas devem ser tomadas precocemente. Keywords: Contrast-induced nephropathy, Copeptin, Myocardial infarction, Percutaneous coronary intervention, Palavras-chave: Nefropatia induzida por contraste, Copeptina, Enfarte do miocárdio, Intervenção coronária percutânea |
| first_indexed | 2024-12-10T22:24:21Z |
| format | Article |
| id | doaj.art-7127f35c2ee8439884b75624b6ab2064 |
| institution | Directory Open Access Journal |
| issn | 0870-2551 |
| language | English |
| last_indexed | 2024-12-10T22:24:21Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Portuguesa de Cardiologia |
| spelling | doaj.art-7127f35c2ee8439884b75624b6ab20642022-12-22T01:31:13ZengElsevierRevista Portuguesa de Cardiologia0870-25512019-12-013812873879Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarctionErsin Yildirim0Ayca Turer Cabbar1Istanbul Umraniye Education and Research Hospital, University of Health Sciences, Department of Cardiology, Turkey; Corresponding author.Yeditepe University Faculty of Medicine, Department of Cardiology, TurkeyObjective: The aim of this study was to investigate the predictive value of copeptin levels in the development of contrast-induced nephropathy (CIN). Methods: A total of 274 patients diagnosed with ST-elevation myocardial infarction (STEMI) and who had undergone primary percutaneous coronary intervention were included in the study. The patients were divided into two groups according to the presence (CIN+) or absence (CIN-) of CIN. These groups were compared in terms of demographic characteristics, laboratory findings and risk factors. Results: Copeptin levels (10.68±6.43 vs. 7.07±05.53 pmol/l; p<0.001) and peak creatinine (1.46±1.20 vs. 1.03±0.20 mg/dl; p=0.005) were significantly higher in the CIN+ group than in the CIN- group. Female gender was significantly more prevalent in the CIN- group compared to the CIN+ group (19% vs. 8.6%; p<0.05). Copeptin level at hospital admission (OR: 2.36, p=0.005) was found to be an independent predictor for CIN development. Conclusion: Copeptin level is an independent predictor of CIN development in patients with acute STEMI that can be detected rapidly and easily. This result indicates that physicians should be aware of the possibility of CIN development in patients with high copeptin levels and preventive measures should start early. Resumo: Objetivos: Análise do valor preditivo dos níveis de copeptina no desenvolvimento da nefropatia induzida por contraste (NIC). Métodos: Foram incluídos no estudo 274 doentes, diagnosticados com enfarte do miocárdio com elevação do segmento ST (STEMI) e submetidos a angioplastia coronária primária. Os doentes foram divididos em dois grupos de acordo com a confirmação de NIC. Estes grupos foram comparados quanto às características demográficas, achados laboratoriais e fatores de risco. Resultados: O nível de copeptina (10,68±6,43 versus 7,07±5,53; p<0,001) e o pico dos níveis de creatinina (1,46±1,20 versus 1,03±0,20; p=0,005) foram significativamente superiores nos grupos de NIC (+) quando comparados com os grupos de NIC (-). A percentagem do género feminino foi significativamente superior no grupo NIC (-) quando comparada com o grupo NIC (+) (19% versus 8,6%; p<0,05). O nível da copeptina no momento do internamento (OR: 2,36, p=0,005) foi considerado como um valor preditor independente no desenvolvimento da NIC. Conclusão: O nível da copeptina é um fator preditor independente do desenvolvimento da NIC em doentes com STEMI agudo. Pode ser detetado rápida e facilmente e este resultado indica que os médicos devem ser mais cuidadosos em relação ao desenvolvimento da NIC em doentes com níveis de copeptina levados. Medidas preventivas devem ser tomadas precocemente. Keywords: Contrast-induced nephropathy, Copeptin, Myocardial infarction, Percutaneous coronary intervention, Palavras-chave: Nefropatia induzida por contraste, Copeptina, Enfarte do miocárdio, Intervenção coronária percutâneahttp://www.sciencedirect.com/science/article/pii/S0870255120300330 |
| spellingShingle | Ersin Yildirim Ayca Turer Cabbar Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction Revista Portuguesa de Cardiologia |
| title | Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction |
| title_full | Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction |
| title_fullStr | Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction |
| title_full_unstemmed | Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction |
| title_short | Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction |
| title_sort | association between copeptin and contrast induced nephropathy in patients with st elevation myocardial infarction |
| url | http://www.sciencedirect.com/science/article/pii/S0870255120300330 |
| work_keys_str_mv | AT ersinyildirim associationbetweencopeptinandcontrastinducednephropathyinpatientswithstelevationmyocardialinfarction AT aycaturercabbar associationbetweencopeptinandcontrastinducednephropathyinpatientswithstelevationmyocardialinfarction |