Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016)
Abstract Background Bacterial pathogens are a major cause of childhood community acquired lower respiratory tract infections (CA-LRTIs), and few data described the impact of antimicrobial resistance on children with CA-LRTIs. This study aims to investigate the antimicrobial resistance in common bact...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-09-01
|
| Series: | BMC Infectious Diseases |
| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2710-4 |
| _version_ | 1818929794898722816 |
|---|---|
| author | Xiaoguang He Mingyu Xie Siping Li Junqin Ye Qi Peng Qiang Ma Xiaomei Lu Baimao Zhong |
| author_facet | Xiaoguang He Mingyu Xie Siping Li Junqin Ye Qi Peng Qiang Ma Xiaomei Lu Baimao Zhong |
| author_sort | Xiaoguang He |
| collection | DOAJ |
| description | Abstract Background Bacterial pathogens are a major cause of childhood community acquired lower respiratory tract infections (CA-LRTIs), and few data described the impact of antimicrobial resistance on children with CA-LRTIs. This study aims to investigate the antimicrobial resistance in common bacterial agents among hospitalized children with CA-LRTIs between 2011 and 2016 in Dongguan, China. Methods Sputum samples were collected from hospitalized children (0–5 years old) with CA-LRTIs in Dongguan Children’s Hospital. Bacterial pathogens were detected using traditional culture methods, and disc diffusion tests were used to determine antibiotic resistance. Results Among the 2360 samples analyzed, 342 (14.5%) were positive for bacterial infection. The most prevalent pathogen was MSSA (2.3%), followed by MRSA (1.5%), E. coli (1.7%), E. coli ESBLs (1.2%), K. pneumonia ESBLs (1.5%), K. pneumonia (1.4%) and S. pneumonia (1.3%). Of the hospitalized patients with bacteria causing of CA-LRTIs, 90.1% were less than 1-year-old. MSSA and MRSA were more commonly isolated in infants less than 3 months. E. coli, K. pneumonia and K. pneumonia ESBLs were more common bacteria causing CA-LRTIs in infants less than 1 month. Resistance levels to penicillins, fluoroquinolones, macrolides, cephalosporins, carbapenems and vancomycin varied in different bacteria. Conclusions S. aureus, E coli and K. pneumonia were the common bacterial isolates recovered from chidren with CA-LTRIs during 2011–2015. Age group of under 1 year old was at a high risk of bacterial infections. Many isolates showed antibiotic resistance level was associated with antibiotic usage in clinic. Increasing surveillance of antibiotic resistance is urgently needed and develops better strategies to cure the antibiotic abuse in China. |
| first_indexed | 2024-12-20T03:50:28Z |
| format | Article |
| id | doaj.art-7128d55ebf5a4887ad9bcc15fbe8750a |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-20T03:50:28Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-7128d55ebf5a4887ad9bcc15fbe8750a2022-12-21T19:54:29ZengBMCBMC Infectious Diseases1471-23342017-09-011711910.1186/s12879-017-2710-4Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016)Xiaoguang He0Mingyu Xie1Siping Li2Junqin Ye3Qi Peng4Qiang Ma5Xiaomei Lu6Baimao Zhong7Department of Pediatric Respiratory Medicine, Dongguan Children’s HospitalDepartment of Pediatric Respiratory Medicine, Dongguan Children’s HospitalDepartment of Pediatric Respiratory Medicine, Dongguan Children’s HospitalDepartment of Pediatric Respiratory Medicine, Dongguan Children’s HospitalDepartment of Pediatric Respiratory Medicine, Dongguan Children’s HospitalDepartment of Pediatric Respiratory Medicine, Dongguan Children’s HospitalDepartment of Pediatric Respiratory Medicine, Dongguan Children’s HospitalDepartment of Pediatric Respiratory Medicine, Dongguan Children’s HospitalAbstract Background Bacterial pathogens are a major cause of childhood community acquired lower respiratory tract infections (CA-LRTIs), and few data described the impact of antimicrobial resistance on children with CA-LRTIs. This study aims to investigate the antimicrobial resistance in common bacterial agents among hospitalized children with CA-LRTIs between 2011 and 2016 in Dongguan, China. Methods Sputum samples were collected from hospitalized children (0–5 years old) with CA-LRTIs in Dongguan Children’s Hospital. Bacterial pathogens were detected using traditional culture methods, and disc diffusion tests were used to determine antibiotic resistance. Results Among the 2360 samples analyzed, 342 (14.5%) were positive for bacterial infection. The most prevalent pathogen was MSSA (2.3%), followed by MRSA (1.5%), E. coli (1.7%), E. coli ESBLs (1.2%), K. pneumonia ESBLs (1.5%), K. pneumonia (1.4%) and S. pneumonia (1.3%). Of the hospitalized patients with bacteria causing of CA-LRTIs, 90.1% were less than 1-year-old. MSSA and MRSA were more commonly isolated in infants less than 3 months. E. coli, K. pneumonia and K. pneumonia ESBLs were more common bacteria causing CA-LRTIs in infants less than 1 month. Resistance levels to penicillins, fluoroquinolones, macrolides, cephalosporins, carbapenems and vancomycin varied in different bacteria. Conclusions S. aureus, E coli and K. pneumonia were the common bacterial isolates recovered from chidren with CA-LTRIs during 2011–2015. Age group of under 1 year old was at a high risk of bacterial infections. Many isolates showed antibiotic resistance level was associated with antibiotic usage in clinic. Increasing surveillance of antibiotic resistance is urgently needed and develops better strategies to cure the antibiotic abuse in China.http://link.springer.com/article/10.1186/s12879-017-2710-4 |
| spellingShingle | Xiaoguang He Mingyu Xie Siping Li Junqin Ye Qi Peng Qiang Ma Xiaomei Lu Baimao Zhong Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016) BMC Infectious Diseases |
| title | Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016) |
| title_full | Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016) |
| title_fullStr | Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016) |
| title_full_unstemmed | Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016) |
| title_short | Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011–2016) |
| title_sort | antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in dongguan china 2011 2016 |
| url | http://link.springer.com/article/10.1186/s12879-017-2710-4 |
| work_keys_str_mv | AT xiaoguanghe antimicrobialresistanceinbacterialpathogensamonghospitalizedchildrenwithcommunityacquiredlowerrespiratorytractinfectionsindongguanchina20112016 AT mingyuxie antimicrobialresistanceinbacterialpathogensamonghospitalizedchildrenwithcommunityacquiredlowerrespiratorytractinfectionsindongguanchina20112016 AT sipingli antimicrobialresistanceinbacterialpathogensamonghospitalizedchildrenwithcommunityacquiredlowerrespiratorytractinfectionsindongguanchina20112016 AT junqinye antimicrobialresistanceinbacterialpathogensamonghospitalizedchildrenwithcommunityacquiredlowerrespiratorytractinfectionsindongguanchina20112016 AT qipeng antimicrobialresistanceinbacterialpathogensamonghospitalizedchildrenwithcommunityacquiredlowerrespiratorytractinfectionsindongguanchina20112016 AT qiangma antimicrobialresistanceinbacterialpathogensamonghospitalizedchildrenwithcommunityacquiredlowerrespiratorytractinfectionsindongguanchina20112016 AT xiaomeilu antimicrobialresistanceinbacterialpathogensamonghospitalizedchildrenwithcommunityacquiredlowerrespiratorytractinfectionsindongguanchina20112016 AT baimaozhong antimicrobialresistanceinbacterialpathogensamonghospitalizedchildrenwithcommunityacquiredlowerrespiratorytractinfectionsindongguanchina20112016 |