Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development
Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable impediment of local hypoxia in tumors. Moreover, PDT could further worsen hypoxia. Therefore, developing effective strat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383519313735 |
| _version_ | 1819021960072396800 |
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| author | Yixin Sun Dongyang Zhao Gang Wang Yang Wang Linlin Cao Jin Sun Qikun Jiang Zhonggui He |
| author_facet | Yixin Sun Dongyang Zhao Gang Wang Yang Wang Linlin Cao Jin Sun Qikun Jiang Zhonggui He |
| author_sort | Yixin Sun |
| collection | DOAJ |
| description | Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable impediment of local hypoxia in tumors. Moreover, PDT could further worsen hypoxia. Therefore, developing effective strategies for manipulating hypoxia and improving the effectiveness of PDT has been a focus on antitumor treatment. In this review, the mechanism and relationship of tumor hypoxia and PDT are discussed. Moreover, we highlight recent trends in the field of nanomedicines to modulate hypoxia for enhancing PDT, such as oxygen supply systems, down-regulation of oxygen consumption and hypoxia utilization. Finally, the opportunities and challenges are put forward to facilitate the development and clinical transformation of PDT. |
| first_indexed | 2024-12-21T04:15:24Z |
| format | Article |
| id | doaj.art-7129cde8de61437ba259eba885075559 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-12-21T04:15:24Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-7129cde8de61437ba259eba8850755592022-12-21T19:16:20ZengElsevierActa Pharmaceutica Sinica B2211-38352020-08-0110813821396Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future developmentYixin Sun0Dongyang Zhao1Gang Wang2Yang Wang3Linlin Cao4Jin Sun5Qikun Jiang6Zhonggui He7Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, ChinaSchool of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaSchool of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaDepartment of Pharmaceutics, the Second Hospital of Dalian Medical University, Dalian 116023, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding authors. Tel./Fax: +86 24 23986325.Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding authors. Tel./Fax: +86 24 23986325.Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable impediment of local hypoxia in tumors. Moreover, PDT could further worsen hypoxia. Therefore, developing effective strategies for manipulating hypoxia and improving the effectiveness of PDT has been a focus on antitumor treatment. In this review, the mechanism and relationship of tumor hypoxia and PDT are discussed. Moreover, we highlight recent trends in the field of nanomedicines to modulate hypoxia for enhancing PDT, such as oxygen supply systems, down-regulation of oxygen consumption and hypoxia utilization. Finally, the opportunities and challenges are put forward to facilitate the development and clinical transformation of PDT.http://www.sciencedirect.com/science/article/pii/S2211383519313735HypoxiaPhotodynamic therapyCancerNanomedicine delivery systemsOxygen |
| spellingShingle | Yixin Sun Dongyang Zhao Gang Wang Yang Wang Linlin Cao Jin Sun Qikun Jiang Zhonggui He Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development Acta Pharmaceutica Sinica B Hypoxia Photodynamic therapy Cancer Nanomedicine delivery systems Oxygen |
| title | Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development |
| title_full | Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development |
| title_fullStr | Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development |
| title_full_unstemmed | Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development |
| title_short | Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development |
| title_sort | recent progress of hypoxia modulated multifunctional nanomedicines to enhance photodynamic therapy opportunities challenges and future development |
| topic | Hypoxia Photodynamic therapy Cancer Nanomedicine delivery systems Oxygen |
| url | http://www.sciencedirect.com/science/article/pii/S2211383519313735 |
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