Effect of Ciprofloxacin and Granulocyte Colony Stimulating Factor in Bactericidal Activity of Polymorphonuclear Leukocytes Against Pseudomonas aeruginosa
The in vitro effect of subinhibitory and inhibitory concentrations of ciprofloxacin and G-CSF on the bactericidal activity of polymorphonuclear leukocytes (PMNL) against Pseudomonas aeruginosa was investigated. PMNL obtained from healthy volunteers were incubated with different concentrations of G-C...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Bilimsel Tip Yayinevi
1998-03-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=1998-3-1-026-030.pdf |
| Summary: | The in vitro effect of subinhibitory and inhibitory concentrations of ciprofloxacin and G-CSF on the bactericidal activity of polymorphonuclear leukocytes (PMNL) against Pseudomonas aeruginosa was investigated. PMNL obtained from healthy volunteers were incubated with different concentrations of G-CSF and ciprofloxacin for 180 min. Although G-CSF showed certain amount of bactericidal effect, this was statistically insignificant when compared with bactericidal activity of PMNL: The minimum inhibitory concentration of ciprofloxacin as well as subinhibitory concentration enhanced the bactericidal activity of PMNL (p<0.05) and the maximal enhancement of activity was observed in combination of inhibitory concentration of ciprofloxacin and 6000 units/ml of G-CSF (p<0.01). Clinical application of this combination could initially target infections in high risk groups, particularly neutropenic patients or patients with impaired neutrophil functions in whom one can expect to decrease antibiotic dosage and prevent likely toxic effects. Effect of such a combination in patients can be evaluated by large scale clinical trials. |
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| ISSN: | 1300-932X 1300-932X |