Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with <i>Curcuma longa</i> and <i>Lepidium sativum</i>
The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with <i>Curcuma longa</i> (CUR) and <i>Lepidium sativum</i> (LS) in hypertensive rats. Hypertension was induced by oral administration of L-NAME (40 mg/kg) for two weeks. Oral admi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/1/33 |
| _version_ | 1797437922053455872 |
|---|---|
| author | Abdul Ahad Mohammad Raish Ibrahim Abdelsalam Abdelrahman Yousef A. Bin Jardan Mohd Aftab Alam Abdullah M. Al-Mohizea Fahad I. Al-Jenoobi |
| author_facet | Abdul Ahad Mohammad Raish Ibrahim Abdelsalam Abdelrahman Yousef A. Bin Jardan Mohd Aftab Alam Abdullah M. Al-Mohizea Fahad I. Al-Jenoobi |
| author_sort | Abdul Ahad |
| collection | DOAJ |
| description | The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with <i>Curcuma longa</i> (CUR) and <i>Lepidium sativum</i> (LS) in hypertensive rats. Hypertension was induced by oral administration of L-NAME (40 mg/kg) for two weeks. Oral administration of CUR or LS shows some substantial antihypertensive activity. The systolic blood pressure (SBP) of hypertensive rats was decreased by 7.04% and 8.78% 12 h after treatment with CUR and LS, respectively, as compared to rats treated with L-NAME alone. LS and CUR display the ability to potentiate the blood pressure-lowering effects of losartan in hypertensive rats. A greater decrease in SBP, by 11.66% and 13.74%, was observed in hypertensive rats treated with CUR + losartan and LS + losartan, respectively. Further, both the investigated herbs, CUR and LS, caused an increase in plasma concentrations of losartan in hypertensive rats. The AUC<sub>0-t</sub>, AUC<sub>0-inf</sub> and AUMC<sub>0-inf</sub> of losartan were increased by 1.25-fold, 1.28-fold and 1.09-fold in hypertensive rats treated with CUR + losartan. A significant (<i>p</i> < 0.05) increase in AUC<sub>0-t</sub> (2.41-fold), AUC<sub>0-inf</sub> (3.86-fold) and AUMC<sub>0-inf</sub> (8.35-fold) of losartan was observed in hypertensive rats treated with LS + losartan. The present study affirms that interactions between CUR or LS with losartan alter both “pharmacokinetics and pharmacodynamics” of the drug. Concurrent administration of losartan with either CUR or LS would require dose adjustment and intermittent blood pressure monitoring for clinical use in hypertensive patients. Additional investigation is necessary to determine the importance of these interactions in humans and to elucidate the mechanisms of action behind these interactions. |
| first_indexed | 2024-03-09T11:29:32Z |
| format | Article |
| id | doaj.art-712af78b788b410bb66c3f7a2b8a7b6d |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T11:29:32Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-712af78b788b410bb66c3f7a2b8a7b6d2023-11-30T23:54:50ZengMDPI AGPharmaceuticals1424-82472022-12-011613310.3390/ph16010033Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with <i>Curcuma longa</i> and <i>Lepidium sativum</i>Abdul Ahad0Mohammad Raish1Ibrahim Abdelsalam Abdelrahman2Yousef A. Bin Jardan3Mohd Aftab Alam4Abdullah M. Al-Mohizea5Fahad I. Al-Jenoobi6Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaThe current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with <i>Curcuma longa</i> (CUR) and <i>Lepidium sativum</i> (LS) in hypertensive rats. Hypertension was induced by oral administration of L-NAME (40 mg/kg) for two weeks. Oral administration of CUR or LS shows some substantial antihypertensive activity. The systolic blood pressure (SBP) of hypertensive rats was decreased by 7.04% and 8.78% 12 h after treatment with CUR and LS, respectively, as compared to rats treated with L-NAME alone. LS and CUR display the ability to potentiate the blood pressure-lowering effects of losartan in hypertensive rats. A greater decrease in SBP, by 11.66% and 13.74%, was observed in hypertensive rats treated with CUR + losartan and LS + losartan, respectively. Further, both the investigated herbs, CUR and LS, caused an increase in plasma concentrations of losartan in hypertensive rats. The AUC<sub>0-t</sub>, AUC<sub>0-inf</sub> and AUMC<sub>0-inf</sub> of losartan were increased by 1.25-fold, 1.28-fold and 1.09-fold in hypertensive rats treated with CUR + losartan. A significant (<i>p</i> < 0.05) increase in AUC<sub>0-t</sub> (2.41-fold), AUC<sub>0-inf</sub> (3.86-fold) and AUMC<sub>0-inf</sub> (8.35-fold) of losartan was observed in hypertensive rats treated with LS + losartan. The present study affirms that interactions between CUR or LS with losartan alter both “pharmacokinetics and pharmacodynamics” of the drug. Concurrent administration of losartan with either CUR or LS would require dose adjustment and intermittent blood pressure monitoring for clinical use in hypertensive patients. Additional investigation is necessary to determine the importance of these interactions in humans and to elucidate the mechanisms of action behind these interactions.https://www.mdpi.com/1424-8247/16/1/33garden cressherb–drug interactionhypertensionL-NAMElosartanpharmacodynamic |
| spellingShingle | Abdul Ahad Mohammad Raish Ibrahim Abdelsalam Abdelrahman Yousef A. Bin Jardan Mohd Aftab Alam Abdullah M. Al-Mohizea Fahad I. Al-Jenoobi Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with <i>Curcuma longa</i> and <i>Lepidium sativum</i> Pharmaceuticals garden cress herb–drug interaction hypertension L-NAME losartan pharmacodynamic |
| title | Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with <i>Curcuma longa</i> and <i>Lepidium sativum</i> |
| title_full | Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with <i>Curcuma longa</i> and <i>Lepidium sativum</i> |
| title_fullStr | Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with <i>Curcuma longa</i> and <i>Lepidium sativum</i> |
| title_full_unstemmed | Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with <i>Curcuma longa</i> and <i>Lepidium sativum</i> |
| title_short | Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with <i>Curcuma longa</i> and <i>Lepidium sativum</i> |
| title_sort | changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with i curcuma longa i and i lepidium sativum i |
| topic | garden cress herb–drug interaction hypertension L-NAME losartan pharmacodynamic |
| url | https://www.mdpi.com/1424-8247/16/1/33 |
| work_keys_str_mv | AT abdulahad changesinpharmacokineticsandpharmacodynamicsoflosartaninexperimentaldiseasedratstreatedwithicurcumalongaiandilepidiumsativumi AT mohammadraish changesinpharmacokineticsandpharmacodynamicsoflosartaninexperimentaldiseasedratstreatedwithicurcumalongaiandilepidiumsativumi AT ibrahimabdelsalamabdelrahman changesinpharmacokineticsandpharmacodynamicsoflosartaninexperimentaldiseasedratstreatedwithicurcumalongaiandilepidiumsativumi AT yousefabinjardan changesinpharmacokineticsandpharmacodynamicsoflosartaninexperimentaldiseasedratstreatedwithicurcumalongaiandilepidiumsativumi AT mohdaftabalam changesinpharmacokineticsandpharmacodynamicsoflosartaninexperimentaldiseasedratstreatedwithicurcumalongaiandilepidiumsativumi AT abdullahmalmohizea changesinpharmacokineticsandpharmacodynamicsoflosartaninexperimentaldiseasedratstreatedwithicurcumalongaiandilepidiumsativumi AT fahadialjenoobi changesinpharmacokineticsandpharmacodynamicsoflosartaninexperimentaldiseasedratstreatedwithicurcumalongaiandilepidiumsativumi |