Immune response varies with rate of dispersal in invasive cane toads (Rhinella marina).
What level of immunocompetence should an animal maintain while undertaking long-distance dispersal? Immune function (surveillance and response) might be down-regulated during prolonged physical exertion due to energy depletion, and/or to avoid autoimmune reactions arising from damaged tissue. On the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4061023?pdf=render |
| _version_ | 1818527084371247104 |
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| author | Gregory P Brown Richard Shine |
| author_facet | Gregory P Brown Richard Shine |
| author_sort | Gregory P Brown |
| collection | DOAJ |
| description | What level of immunocompetence should an animal maintain while undertaking long-distance dispersal? Immune function (surveillance and response) might be down-regulated during prolonged physical exertion due to energy depletion, and/or to avoid autoimmune reactions arising from damaged tissue. On the other hand, heightened immune vigilance might be favored if the organism encounters novel pathogens as it enters novel environments. We assessed the links between immune defense and long-distance movement in a population of invasive cane toads (Rhinella marina) in Australia. Toads were radio-tracked for seven days to measure their activity levels and were then captured and subjected to a suite of immune assays. Toads that moved further showed decreased bacteria-killing ability in their plasma and decreased phagocytic activity in their whole blood, but a heightened skin-swelling response to phytohemagglutinin. Baseline and post-stress corticosterone levels were unrelated to distance moved. Thus, long-distance movement in cane toads is associated with a dampened response in some systems and enhanced response in another. This pattern suggests that sustained activity is accompanied by trade-offs among immune components rather than an overall down or up-regulation. The finding that high mobility is accompanied by modification of the immune system has important implications for animal invasions. |
| first_indexed | 2024-12-11T06:31:32Z |
| format | Article |
| id | doaj.art-712b200262b348d4859e0bdb31f949a0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T06:31:32Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-712b200262b348d4859e0bdb31f949a02022-12-22T01:17:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9973410.1371/journal.pone.0099734Immune response varies with rate of dispersal in invasive cane toads (Rhinella marina).Gregory P BrownRichard ShineWhat level of immunocompetence should an animal maintain while undertaking long-distance dispersal? Immune function (surveillance and response) might be down-regulated during prolonged physical exertion due to energy depletion, and/or to avoid autoimmune reactions arising from damaged tissue. On the other hand, heightened immune vigilance might be favored if the organism encounters novel pathogens as it enters novel environments. We assessed the links between immune defense and long-distance movement in a population of invasive cane toads (Rhinella marina) in Australia. Toads were radio-tracked for seven days to measure their activity levels and were then captured and subjected to a suite of immune assays. Toads that moved further showed decreased bacteria-killing ability in their plasma and decreased phagocytic activity in their whole blood, but a heightened skin-swelling response to phytohemagglutinin. Baseline and post-stress corticosterone levels were unrelated to distance moved. Thus, long-distance movement in cane toads is associated with a dampened response in some systems and enhanced response in another. This pattern suggests that sustained activity is accompanied by trade-offs among immune components rather than an overall down or up-regulation. The finding that high mobility is accompanied by modification of the immune system has important implications for animal invasions.http://europepmc.org/articles/PMC4061023?pdf=render |
| spellingShingle | Gregory P Brown Richard Shine Immune response varies with rate of dispersal in invasive cane toads (Rhinella marina). PLoS ONE |
| title | Immune response varies with rate of dispersal in invasive cane toads (Rhinella marina). |
| title_full | Immune response varies with rate of dispersal in invasive cane toads (Rhinella marina). |
| title_fullStr | Immune response varies with rate of dispersal in invasive cane toads (Rhinella marina). |
| title_full_unstemmed | Immune response varies with rate of dispersal in invasive cane toads (Rhinella marina). |
| title_short | Immune response varies with rate of dispersal in invasive cane toads (Rhinella marina). |
| title_sort | immune response varies with rate of dispersal in invasive cane toads rhinella marina |
| url | http://europepmc.org/articles/PMC4061023?pdf=render |
| work_keys_str_mv | AT gregorypbrown immuneresponsevarieswithrateofdispersalininvasivecanetoadsrhinellamarina AT richardshine immuneresponsevarieswithrateofdispersalininvasivecanetoadsrhinellamarina |