Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic Applications
This study was designed to check the potential of secondary metabolites of the selected plants; <i>Citrullus colocynthis</i>, <i>Solanum nigrum</i>, <i>Solanum surattense,</i> <i>Calotropis procera</i>, <i>Agave americana</i>, and <i>...
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/18/5935 |
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| author | Fatimah Saeed Aldughaylibi Muhammad Asam Raza Sumaira Naeem Humera Rafi Mir Waqas Alam Basma Souayeh Mohd Farhan Muhammad Aamir Noushi Zaidi Tanveer Ahmad Mir |
| author_facet | Fatimah Saeed Aldughaylibi Muhammad Asam Raza Sumaira Naeem Humera Rafi Mir Waqas Alam Basma Souayeh Mohd Farhan Muhammad Aamir Noushi Zaidi Tanveer Ahmad Mir |
| author_sort | Fatimah Saeed Aldughaylibi |
| collection | DOAJ |
| description | This study was designed to check the potential of secondary metabolites of the selected plants; <i>Citrullus colocynthis</i>, <i>Solanum nigrum</i>, <i>Solanum surattense,</i> <i>Calotropis procera</i>, <i>Agave americana</i>, and <i>Anagallis arvensis</i> for antioxidant, antibacterial, antifungal, and antidiabetic agents. Plant material was soaked in ethanol/methanol to get the crude extract, which was further partitioned via solvent extraction technique. GCMS and FTIR analytical techniques were applied to check the compounds responsible for causing antioxidant, antimicrobial, and antidiabetic activities. It was concluded that about 80% of studied extracts/fractions were active against α-amylase, ranging from 43 to 96%. The highest activity (96.63%) was exhibited by butanol fractions of <i>A. arvensis</i> while the least response (43.65%) was shown by the aqueous fraction of <i>C. colocynthis</i> and the methanol fraction of fruit of <i>S. surattense.</i> The highest antioxidant activity was shown by the ethyl acetate fraction of <i>Anagallis arvensis</i> (78.1%), while aqueous as well as n-hexane fractions are the least active throughout the assay. Results showed that all tested plants can be an excellent source of natural products with potential antimicrobial, antioxidant, and antidiabetic potential. The biological response of these species is depicted as a good therapeutic agent, and, in the future, it can be encapsulated for drug discovery. |
| first_indexed | 2024-03-09T23:01:06Z |
| format | Article |
| id | doaj.art-712ba97bb03248b2bc90003097749bf2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:01:06Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-712ba97bb03248b2bc90003097749bf22023-11-23T18:01:28ZengMDPI AGMolecules1420-30492022-09-012718593510.3390/molecules27185935Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic ApplicationsFatimah Saeed Aldughaylibi0Muhammad Asam Raza1Sumaira Naeem2Humera Rafi3Mir Waqas Alam4Basma Souayeh5Mohd Farhan6Muhammad Aamir7Noushi Zaidi8Tanveer Ahmad Mir9Department of Physics, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Chemistry, University of Gujrat, Gujrat 50700, PakistanDepartment of Chemistry, University of Gujrat, Gujrat 50700, PakistanDepartment of Chemistry, University of Gujrat, Gujrat 50700, PakistanDepartment of Physics, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Physics, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Basic Sciences, Preparatory Year Deanship, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Basic Sciences, Preparatory Year Deanship, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Basic Sciences, Preparatory Year Deanship, King Faisal University, Al-Ahsa 31982, Saudi ArabiaLaboratory of Tissue/Organ Bioengineering and BioMEMS, Organ Transplant Centre of Excellence, Transplantation Research & Innovation (Dpt)-R, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi ArabiaThis study was designed to check the potential of secondary metabolites of the selected plants; <i>Citrullus colocynthis</i>, <i>Solanum nigrum</i>, <i>Solanum surattense,</i> <i>Calotropis procera</i>, <i>Agave americana</i>, and <i>Anagallis arvensis</i> for antioxidant, antibacterial, antifungal, and antidiabetic agents. Plant material was soaked in ethanol/methanol to get the crude extract, which was further partitioned via solvent extraction technique. GCMS and FTIR analytical techniques were applied to check the compounds responsible for causing antioxidant, antimicrobial, and antidiabetic activities. It was concluded that about 80% of studied extracts/fractions were active against α-amylase, ranging from 43 to 96%. The highest activity (96.63%) was exhibited by butanol fractions of <i>A. arvensis</i> while the least response (43.65%) was shown by the aqueous fraction of <i>C. colocynthis</i> and the methanol fraction of fruit of <i>S. surattense.</i> The highest antioxidant activity was shown by the ethyl acetate fraction of <i>Anagallis arvensis</i> (78.1%), while aqueous as well as n-hexane fractions are the least active throughout the assay. Results showed that all tested plants can be an excellent source of natural products with potential antimicrobial, antioxidant, and antidiabetic potential. The biological response of these species is depicted as a good therapeutic agent, and, in the future, it can be encapsulated for drug discovery.https://www.mdpi.com/1420-3049/27/18/5935antimicrobialantidiabeticantioxidantmedicinal plantsGC-MS |
| spellingShingle | Fatimah Saeed Aldughaylibi Muhammad Asam Raza Sumaira Naeem Humera Rafi Mir Waqas Alam Basma Souayeh Mohd Farhan Muhammad Aamir Noushi Zaidi Tanveer Ahmad Mir Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic Applications Molecules antimicrobial antidiabetic antioxidant medicinal plants GC-MS |
| title | Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic Applications |
| title_full | Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic Applications |
| title_fullStr | Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic Applications |
| title_full_unstemmed | Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic Applications |
| title_short | Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic Applications |
| title_sort | extraction of bioactive compounds for antioxidant antimicrobial and antidiabetic applications |
| topic | antimicrobial antidiabetic antioxidant medicinal plants GC-MS |
| url | https://www.mdpi.com/1420-3049/27/18/5935 |
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