Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Bone Metabolism: a Systematic Review and Meta-analysis
Background Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with bone metabolism in Western population. Chinese population manifest different development progress of OSAHS and bone metabolism owing to their own specific physiological characteristics compared to the Western population....
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2022-10-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220104.pdf |
| _version_ | 1797216901303107584 |
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| author | Yunping MU, Xiaoxue WEI, Kadier SAJIDANMU·, Daqiao ZHU, Changgui SHI, Bingqian ZHU |
| author_facet | Yunping MU, Xiaoxue WEI, Kadier SAJIDANMU·, Daqiao ZHU, Changgui SHI, Bingqian ZHU |
| author_sort | Yunping MU, Xiaoxue WEI, Kadier SAJIDANMU·, Daqiao ZHU, Changgui SHI, Bingqian ZHU |
| collection | DOAJ |
| description | Background Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with bone metabolism in Western population. Chinese population manifest different development progress of OSAHS and bone metabolism owing to their own specific physiological characteristics compared to the Western population. Although the association between OSAHS and bone metabolism may be confounded by underlying diseases, the association between them among healthy Chinese people remains unknown. Objective To examine the relationship between OSAHS and bone metabolism in Chinese people without underlying conditions using a review and Meta-analysis, providing evidence for improving bone health. Methods This review was conducted following the PRISMA guidelines. Electronic databases, such as PubMed, Embase, and CINAHL, were searched from inception to December 2020 for studies regarding bone metabolism and OSAHS in Chinese adults (aged≥18 years) in which those with and without OSAHS were classified as OSAHS and control groups, respectively (OSAHS was diagnosed based on the Guidelines for the Diagnosis and Management of Obstructive Sleep Apnea Hypopnea Syndrome) . Outcome indicators include one or more bone metabolism indicators. Three researchers independently performed literature screening and data extraction. Two researchers independently performed the quality appraisal using the JBI Critical Appraisal Checklist for Analytical Cross Sectional Studies. Data were analyzed using Stata 15.1. Results Ten studies were included, with a total of 898 participants, and 653 of whom had OSAHS. Nine were cross-sectional studies and one was a quasi-experimental study. According to the JBI quality assessment tool, the nine cross-sectional studies were of high quality on items 1 to 5, and 4 of which did not control for the confounding factors. Based on the Meta-analysis, compared to the control group, OSAHS group had lower lumbar BMD 〔SMD (95%CI) =-1.758 (-2.300, -1.217) 〕, lower femoral neck BMD〔SMD (95%CI) =-1.260 (-1.949, -0.571) 〕, higher β-CTX〔SMD (95%CI) =0.803 (0.122, 1.484) 〕, and higher P1NP〔SMD (95%CI) =0.820 (0.318, 1.321) 〕. Apnea-hypopnea index had a negative correlation with lumbar BMD〔r (95%CI) =-0.36 (-0.57, -0.12) 〕 and positive correlations with β-CTX〔r (95%CI) =0.39 (0.29, 0.47) 〕and P1NP〔r (95%CI) =0.36 (0.16, 0.53) 〕. Conclusion Among Chinese adults without underlying conditions, OSAHS may reduce BMD by increasing bone resorption, thereby elevating the risk of osteoporosis or fractures. |
| first_indexed | 2024-04-24T11:53:19Z |
| format | Article |
| id | doaj.art-712c940198374ae2a552c465a9650e14 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:53:19Z |
| publishDate | 2022-10-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-712c940198374ae2a552c465a9650e142024-04-09T06:09:49ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-10-0125303825383310.12114/j.issn.1007-9572.2022.0104Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Bone Metabolism: a Systematic Review and Meta-analysisYunping MU, Xiaoxue WEI, Kadier SAJIDANMU·, Daqiao ZHU, Changgui SHI, Bingqian ZHU01. Shanghai JiaoTong University School of Nursing, Shanghai 200025, China;2. Minimally Invasive Spine Surgery Center, Naval Medical University Affiliated Changzheng Hospital, Shanghai 200003, ChinaBackground Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with bone metabolism in Western population. Chinese population manifest different development progress of OSAHS and bone metabolism owing to their own specific physiological characteristics compared to the Western population. Although the association between OSAHS and bone metabolism may be confounded by underlying diseases, the association between them among healthy Chinese people remains unknown. Objective To examine the relationship between OSAHS and bone metabolism in Chinese people without underlying conditions using a review and Meta-analysis, providing evidence for improving bone health. Methods This review was conducted following the PRISMA guidelines. Electronic databases, such as PubMed, Embase, and CINAHL, were searched from inception to December 2020 for studies regarding bone metabolism and OSAHS in Chinese adults (aged≥18 years) in which those with and without OSAHS were classified as OSAHS and control groups, respectively (OSAHS was diagnosed based on the Guidelines for the Diagnosis and Management of Obstructive Sleep Apnea Hypopnea Syndrome) . Outcome indicators include one or more bone metabolism indicators. Three researchers independently performed literature screening and data extraction. Two researchers independently performed the quality appraisal using the JBI Critical Appraisal Checklist for Analytical Cross Sectional Studies. Data were analyzed using Stata 15.1. Results Ten studies were included, with a total of 898 participants, and 653 of whom had OSAHS. Nine were cross-sectional studies and one was a quasi-experimental study. According to the JBI quality assessment tool, the nine cross-sectional studies were of high quality on items 1 to 5, and 4 of which did not control for the confounding factors. Based on the Meta-analysis, compared to the control group, OSAHS group had lower lumbar BMD 〔SMD (95%CI) =-1.758 (-2.300, -1.217) 〕, lower femoral neck BMD〔SMD (95%CI) =-1.260 (-1.949, -0.571) 〕, higher β-CTX〔SMD (95%CI) =0.803 (0.122, 1.484) 〕, and higher P1NP〔SMD (95%CI) =0.820 (0.318, 1.321) 〕. Apnea-hypopnea index had a negative correlation with lumbar BMD〔r (95%CI) =-0.36 (-0.57, -0.12) 〕 and positive correlations with β-CTX〔r (95%CI) =0.39 (0.29, 0.47) 〕and P1NP〔r (95%CI) =0.36 (0.16, 0.53) 〕. Conclusion Among Chinese adults without underlying conditions, OSAHS may reduce BMD by increasing bone resorption, thereby elevating the risk of osteoporosis or fractures.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220104.pdfsleep apnea, obstructive|apnea hypopnea index|bone density|bone metabolism|systematic review|meta-analysis |
| spellingShingle | Yunping MU, Xiaoxue WEI, Kadier SAJIDANMU·, Daqiao ZHU, Changgui SHI, Bingqian ZHU Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Bone Metabolism: a Systematic Review and Meta-analysis Zhongguo quanke yixue sleep apnea, obstructive|apnea hypopnea index|bone density|bone metabolism|systematic review|meta-analysis |
| title | Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Bone Metabolism: a Systematic Review and Meta-analysis |
| title_full | Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Bone Metabolism: a Systematic Review and Meta-analysis |
| title_fullStr | Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Bone Metabolism: a Systematic Review and Meta-analysis |
| title_full_unstemmed | Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Bone Metabolism: a Systematic Review and Meta-analysis |
| title_short | Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Bone Metabolism: a Systematic Review and Meta-analysis |
| title_sort | relationship between obstructive sleep apnea hypopnea syndrome and bone metabolism a systematic review and meta analysis |
| topic | sleep apnea, obstructive|apnea hypopnea index|bone density|bone metabolism|systematic review|meta-analysis |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220104.pdf |
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