Effect of Nicotinic Acid (Niacin) on Body Weight in New Zealand White Rabbits on Atherogenic Diet
Background: To study the effect of Nicotinic acid (Niacin) on body weight in NZW rabbits on atherogenic diet. Methods: In this experimental study, forty adult male New Zealand White (NZW) rabbits were randomly assigned to four groups A, B, C and D, each comprising ten rabbits. Group A served as Pure...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2012-12-01
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| Series: | Journal of Rawalpindi Medical College |
| Subjects: | |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/585 |
| _version_ | 1819028683362402304 |
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| author | Naheed Kausar |
| author_facet | Naheed Kausar |
| author_sort | Naheed Kausar |
| collection | DOAJ |
| description | Background: To study the effect of Nicotinic acid
(Niacin) on body weight in NZW rabbits on atherogenic
diet.
Methods: In this experimental study, forty adult male
New Zealand White (NZW) rabbits were randomly
assigned to four groups A, B, C and D, each comprising ten
rabbits. Group A served as Pure Control and received
standard animal house diet (concentrated diet). Group B as
treated control was given atherogenic diet (concentrated
diet + 0.5% cholesterol), Group C as an experimental group
was given Niacin in a dose of 15mg/kg b.w mixed in
atherogenic diet (concentrated diet + 0.5% cholesterol) for
two months. Group D served as an experimental group
received atherogenic diet (concentrated diet + 0.5%
cholesterol) for two months then was shifted to standard
animal house diet (concentrated diet) mixed with Niacin in
a dose of 15mg/kg b.w. Rabbits were weighed at the
beginning of the experiment and then before their
sacrifice.
Results: - The mean initial body weight (Wi)of rabbits
in group A,B,C and D was 1.875±0.094, 1.670±0.067,
1.660±0.085 and 1.805±0.038 kg respectively. The mean final
body weight(Wf) of rabbits was 1.850±0.099, 1.920±0.046,
1.695±0.069 and 1.745±0.052 kg respectively. ANOVA
showed significant (p<0.05) difference in mean values of
body weight among the groups. Post Hoc test using Least
Significant Difference (LSD) showed significant
difference (p<0.05), when weight change was compared
among the groups.
Conclusions: - Atherogenic diet produced increase in
body weight of rabbits. Less weight gain was seen in
rabbits on atherogenic diet with niacin supplementation.
Marked response to reduction in body weight was
observed in rabbits with cholesterol restriction and niacin
supplementation |
| first_indexed | 2024-12-21T06:02:16Z |
| format | Article |
| id | doaj.art-712ce19cdaa746569e6397b66cd4daf9 |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-12-21T06:02:16Z |
| publishDate | 2012-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-712ce19cdaa746569e6397b66cd4daf92022-12-21T19:13:44ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702012-12-01162Effect of Nicotinic Acid (Niacin) on Body Weight in New Zealand White Rabbits on Atherogenic DietNaheed Kausar0Department of Anatomy;Nawaz Sharif Medical College; University of GujratBackground: To study the effect of Nicotinic acid (Niacin) on body weight in NZW rabbits on atherogenic diet. Methods: In this experimental study, forty adult male New Zealand White (NZW) rabbits were randomly assigned to four groups A, B, C and D, each comprising ten rabbits. Group A served as Pure Control and received standard animal house diet (concentrated diet). Group B as treated control was given atherogenic diet (concentrated diet + 0.5% cholesterol), Group C as an experimental group was given Niacin in a dose of 15mg/kg b.w mixed in atherogenic diet (concentrated diet + 0.5% cholesterol) for two months. Group D served as an experimental group received atherogenic diet (concentrated diet + 0.5% cholesterol) for two months then was shifted to standard animal house diet (concentrated diet) mixed with Niacin in a dose of 15mg/kg b.w. Rabbits were weighed at the beginning of the experiment and then before their sacrifice. Results: - The mean initial body weight (Wi)of rabbits in group A,B,C and D was 1.875±0.094, 1.670±0.067, 1.660±0.085 and 1.805±0.038 kg respectively. The mean final body weight(Wf) of rabbits was 1.850±0.099, 1.920±0.046, 1.695±0.069 and 1.745±0.052 kg respectively. ANOVA showed significant (p<0.05) difference in mean values of body weight among the groups. Post Hoc test using Least Significant Difference (LSD) showed significant difference (p<0.05), when weight change was compared among the groups. Conclusions: - Atherogenic diet produced increase in body weight of rabbits. Less weight gain was seen in rabbits on atherogenic diet with niacin supplementation. Marked response to reduction in body weight was observed in rabbits with cholesterol restriction and niacin supplementationhttps://www.journalrmc.com/index.php/JRMC/article/view/585Atherogenic dietNiacin |
| spellingShingle | Naheed Kausar Effect of Nicotinic Acid (Niacin) on Body Weight in New Zealand White Rabbits on Atherogenic Diet Journal of Rawalpindi Medical College Atherogenic diet Niacin |
| title | Effect of Nicotinic Acid (Niacin) on Body Weight in New Zealand White Rabbits on Atherogenic Diet |
| title_full | Effect of Nicotinic Acid (Niacin) on Body Weight in New Zealand White Rabbits on Atherogenic Diet |
| title_fullStr | Effect of Nicotinic Acid (Niacin) on Body Weight in New Zealand White Rabbits on Atherogenic Diet |
| title_full_unstemmed | Effect of Nicotinic Acid (Niacin) on Body Weight in New Zealand White Rabbits on Atherogenic Diet |
| title_short | Effect of Nicotinic Acid (Niacin) on Body Weight in New Zealand White Rabbits on Atherogenic Diet |
| title_sort | effect of nicotinic acid niacin on body weight in new zealand white rabbits on atherogenic diet |
| topic | Atherogenic diet Niacin |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/585 |
| work_keys_str_mv | AT naheedkausar effectofnicotinicacidniacinonbodyweightinnewzealandwhiterabbitsonatherogenicdiet |