Incidence of Asymptomatic <i>Shigella</i> Infection and Association with the Composite Index of Anthropometric Failure among Children Aged 1–24 Months in Low-Resource Settings
Asymptomatic or subclinical infection by diarrheal enteropathogens during childhood has been linked to poor health and nutritional outcomes. In this study, we aimed to assess the impact of asymptomatic <i>Shigella</i> infection on different forms of childhood malnutrition including the c...
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MDPI AG
2022-04-01
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| Online Access: | https://www.mdpi.com/2075-1729/12/5/607 |
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| author | Sabiha Nasrin Md. Ahshanul Haque Parag Palit Rina Das Mustafa Mahfuz Abu S. G. Faruque Tahmeed Ahmed |
| author_facet | Sabiha Nasrin Md. Ahshanul Haque Parag Palit Rina Das Mustafa Mahfuz Abu S. G. Faruque Tahmeed Ahmed |
| author_sort | Sabiha Nasrin |
| collection | DOAJ |
| description | Asymptomatic or subclinical infection by diarrheal enteropathogens during childhood has been linked to poor health and nutritional outcomes. In this study, we aimed to assess the impact of asymptomatic <i>Shigella</i> infection on different forms of childhood malnutrition including the composite index of anthropometric failure (CIAF). We used data from 1715 children enrolled in the multi-country birth cohort study, MAL-ED, from November 2009 to February 2012. Monthly non-diarrheal stools were collected and assessed using TaqMan Array Cards (TAC). Poisson regression was used to calculate incidence rates of asymptomatic <i>Shigella</i> infection. Generalized estimating equations (GEE) were used to assess the association between asymptomatic <i>Shigella</i> infection and nutritional indicators after adjusting for relevant covariates. Incidence rates per 100 child-months were higher in Tanzania, Bangladesh and Peru. Overall, after adjusting for relevant covariates, asymptomatic <i>Shigella</i> infection was significantly associated with stunting (aOR 1.60; 95% CI: 1.50, 1.70), wasting (aOR 1.26; 95% CI: 1.09, 1.46), underweight (aOR 1.45; 95% CI: 1.35, 1.56), and CIAF (aOR 1.55; 95% CI: 1.46, 1.65) in all the study sites except for Brazil. The high incidence rates of asymptomatic <i>Shigella</i> infection underscore the immediate need for <i>Shigella</i> vaccines to avert the long-term sequelae involving childhood growth. |
| first_indexed | 2024-03-10T03:34:46Z |
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| language | English |
| last_indexed | 2024-03-10T03:34:46Z |
| publishDate | 2022-04-01 |
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| series | Life |
| spelling | doaj.art-712ddfa36cbe4c259e29f1cbf91f6bec2023-11-23T11:48:41ZengMDPI AGLife2075-17292022-04-0112560710.3390/life12050607Incidence of Asymptomatic <i>Shigella</i> Infection and Association with the Composite Index of Anthropometric Failure among Children Aged 1–24 Months in Low-Resource SettingsSabiha Nasrin0Md. Ahshanul Haque1Parag Palit2Rina Das3Mustafa Mahfuz4Abu S. G. Faruque5Tahmeed Ahmed6Nutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka 1212, BangladeshNutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka 1212, BangladeshNutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka 1212, BangladeshNutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka 1212, BangladeshNutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka 1212, BangladeshNutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka 1212, BangladeshNutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka 1212, BangladeshAsymptomatic or subclinical infection by diarrheal enteropathogens during childhood has been linked to poor health and nutritional outcomes. In this study, we aimed to assess the impact of asymptomatic <i>Shigella</i> infection on different forms of childhood malnutrition including the composite index of anthropometric failure (CIAF). We used data from 1715 children enrolled in the multi-country birth cohort study, MAL-ED, from November 2009 to February 2012. Monthly non-diarrheal stools were collected and assessed using TaqMan Array Cards (TAC). Poisson regression was used to calculate incidence rates of asymptomatic <i>Shigella</i> infection. Generalized estimating equations (GEE) were used to assess the association between asymptomatic <i>Shigella</i> infection and nutritional indicators after adjusting for relevant covariates. Incidence rates per 100 child-months were higher in Tanzania, Bangladesh and Peru. Overall, after adjusting for relevant covariates, asymptomatic <i>Shigella</i> infection was significantly associated with stunting (aOR 1.60; 95% CI: 1.50, 1.70), wasting (aOR 1.26; 95% CI: 1.09, 1.46), underweight (aOR 1.45; 95% CI: 1.35, 1.56), and CIAF (aOR 1.55; 95% CI: 1.46, 1.65) in all the study sites except for Brazil. The high incidence rates of asymptomatic <i>Shigella</i> infection underscore the immediate need for <i>Shigella</i> vaccines to avert the long-term sequelae involving childhood growth.https://www.mdpi.com/2075-1729/12/5/607asymptomatic <i>Shigella</i> infectionchildhood malnutritioncomposite index of anthropometric failure (CIAF)MAL-ED |
| spellingShingle | Sabiha Nasrin Md. Ahshanul Haque Parag Palit Rina Das Mustafa Mahfuz Abu S. G. Faruque Tahmeed Ahmed Incidence of Asymptomatic <i>Shigella</i> Infection and Association with the Composite Index of Anthropometric Failure among Children Aged 1–24 Months in Low-Resource Settings Life asymptomatic <i>Shigella</i> infection childhood malnutrition composite index of anthropometric failure (CIAF) MAL-ED |
| title | Incidence of Asymptomatic <i>Shigella</i> Infection and Association with the Composite Index of Anthropometric Failure among Children Aged 1–24 Months in Low-Resource Settings |
| title_full | Incidence of Asymptomatic <i>Shigella</i> Infection and Association with the Composite Index of Anthropometric Failure among Children Aged 1–24 Months in Low-Resource Settings |
| title_fullStr | Incidence of Asymptomatic <i>Shigella</i> Infection and Association with the Composite Index of Anthropometric Failure among Children Aged 1–24 Months in Low-Resource Settings |
| title_full_unstemmed | Incidence of Asymptomatic <i>Shigella</i> Infection and Association with the Composite Index of Anthropometric Failure among Children Aged 1–24 Months in Low-Resource Settings |
| title_short | Incidence of Asymptomatic <i>Shigella</i> Infection and Association with the Composite Index of Anthropometric Failure among Children Aged 1–24 Months in Low-Resource Settings |
| title_sort | incidence of asymptomatic i shigella i infection and association with the composite index of anthropometric failure among children aged 1 24 months in low resource settings |
| topic | asymptomatic <i>Shigella</i> infection childhood malnutrition composite index of anthropometric failure (CIAF) MAL-ED |
| url | https://www.mdpi.com/2075-1729/12/5/607 |
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