Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transduc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.2003161 |
| _version_ | 1827809250695446528 |
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| author | Fabrizio Simeoni Tim CP Somervaille |
| author_facet | Fabrizio Simeoni Tim CP Somervaille |
| author_sort | Fabrizio Simeoni |
| collection | DOAJ |
| description | Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes. |
| first_indexed | 2024-03-11T22:39:54Z |
| format | Article |
| id | doaj.art-712e6d05383648b3ba67ee2136f01768 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:54Z |
| publishDate | 2021-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-712e6d05383648b3ba67ee2136f017682023-09-22T09:19:44ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-11-018610.1080/23723556.2021.20031612003161Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemiaFabrizio Simeoni0Tim CP Somervaille1The University of ManchesterThe University of ManchesterTissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.http://dx.doi.org/10.1080/23723556.2021.2003161grouchotle3amlfoxc1runx1 |
| spellingShingle | Fabrizio Simeoni Tim CP Somervaille Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia Molecular & Cellular Oncology groucho tle3 aml foxc1 runx1 |
| title | Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia |
| title_full | Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia |
| title_fullStr | Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia |
| title_full_unstemmed | Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia |
| title_short | Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia |
| title_sort | enhancer recruitment of a runx1 hdac1 and tle3 co repressor complex by mis expressed foxc1 blocks differentiation in acute myeloid leukemia |
| topic | groucho tle3 aml foxc1 runx1 |
| url | http://dx.doi.org/10.1080/23723556.2021.2003161 |
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