Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transduc...

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Bibliographic Details
Main Authors: Fabrizio Simeoni, Tim CP Somervaille
Format: Article
Language:English
Published: Taylor & Francis Group 2021-11-01
Series:Molecular & Cellular Oncology
Subjects:
groucho
tle3
aml
foxc1
runx1
Online Access:http://dx.doi.org/10.1080/23723556.2021.2003161

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