LNA-anti-miR-150 alleviates renal interstitial fibrosis by reducing pro-inflammatory M1/M2 macrophage polarization

LNA-anti-miR-150 alleviates renal interstitial fibrosis by reducing pro-inflammatory M1/M2 macrophage polarization

Renal interstitial fibrosis (RIF) is a common pathological feature contributing to chronic injury and maladaptive repair following acute kidney injury. Currently, there is no effective therapy for RIF. We have reported that locked nuclear acid (LNA)-anti-miR-150 antagonizes pro-fibrotic pathways in...

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Bibliographic Details
Main Authors: Xiangnan Hao, Junjun Luan, Congcong Jiao, Cong Ma, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Jingqi Fu, Enyin Lai, Beiru Zhang, Yanqiu Wang, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
LNA-anti-miR-150
folic acid
SOCS1/JAK1/STAT1
M1/M2 macrophage polarization
renal fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.913007/full

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