Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells
SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2). It has been suggested that SOX2-OT can regulate its overlapping gene, SOX2. Studies demonstrated...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2021-06-01
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| Series: | Research Ideas and Outcomes |
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| Online Access: | https://riojournal.com/article/69726/download/pdf/ |
| _version_ | 1818367713196638208 |
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| author | Dao-Yin Dong Pu-Yu Li |
| author_facet | Dao-Yin Dong Pu-Yu Li |
| author_sort | Dao-Yin Dong |
| collection | DOAJ |
| description | SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2). It has been suggested that SOX2-OT can regulate its overlapping gene, SOX2. Studies demonstrated that elevated SOX2-OT promotes SOX2 expression in cancer cells, whereas levels of SOX2-OT are inversely correlated with levels of SOX2 in embryonic stem cells. It is not clear why there is a tremendous discrepancy in the regulation of SOX2 by SOX2-OT in cancer cells and embryonic stem cells. Due to the diversified transcription of the SOX2-OT gene, we hypothesize that differential expression of transcripts of the SOX2-OT gene in cancer cells and embryonic stem cells may contribute to the divergence in the regulatory relationship of SOX2-OT and SOX2. A CRISPR screening platform can be leveraged to systemic evaluate which transcript of the SOX2-OT gene may be responsible for upregulation or downregulation of SOX2 in cancer cells and embryonic stem cells, respectively. |
| first_indexed | 2024-12-13T22:56:25Z |
| format | Article |
| id | doaj.art-713043cec7d84d3397a6d57026ff5a04 |
| institution | Directory Open Access Journal |
| issn | 2367-7163 |
| language | English |
| last_indexed | 2024-12-13T22:56:25Z |
| publishDate | 2021-06-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Research Ideas and Outcomes |
| spelling | doaj.art-713043cec7d84d3397a6d57026ff5a042022-12-21T23:28:30ZengPensoft PublishersResearch Ideas and Outcomes2367-71632021-06-0171610.3897/rio.7.e6972669726Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cellsDao-Yin Dong0Pu-Yu Li1Department of Public Health, School of Basic Medical Sciences, Henan University of Science and TechnologyDepartment of General Medicine, The First Affiliated Hospital of Henan University of Science and TechnologySOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2). It has been suggested that SOX2-OT can regulate its overlapping gene, SOX2. Studies demonstrated that elevated SOX2-OT promotes SOX2 expression in cancer cells, whereas levels of SOX2-OT are inversely correlated with levels of SOX2 in embryonic stem cells. It is not clear why there is a tremendous discrepancy in the regulation of SOX2 by SOX2-OT in cancer cells and embryonic stem cells. Due to the diversified transcription of the SOX2-OT gene, we hypothesize that differential expression of transcripts of the SOX2-OT gene in cancer cells and embryonic stem cells may contribute to the divergence in the regulatory relationship of SOX2-OT and SOX2. A CRISPR screening platform can be leveraged to systemic evaluate which transcript of the SOX2-OT gene may be responsible for upregulation or downregulation of SOX2 in cancer cells and embryonic stem cells, respectively.https://riojournal.com/article/69726/download/pdf/SOX2-OTSOX2Cancer cellsembryonic stem cells |
| spellingShingle | Dao-Yin Dong Pu-Yu Li Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells Research Ideas and Outcomes SOX2-OT SOX2 Cancer cells embryonic stem cells |
| title | Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells |
| title_full | Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells |
| title_fullStr | Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells |
| title_full_unstemmed | Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells |
| title_short | Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells |
| title_sort | identifying sox2 ot transcript that is responsible for regulating sox2 in cancer cells and embryonic stem cells |
| topic | SOX2-OT SOX2 Cancer cells embryonic stem cells |
| url | https://riojournal.com/article/69726/download/pdf/ |
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