Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review
SUMMARY Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Brazilian Society of Endocrinology and Metabolism
2017-02-01
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| Series: | Archives of Endocrinology and Metabolism |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200198&lng=en&tlng=en |
| _version_ | 1811213828578344960 |
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| author | Mohammad Shafi Kuchay Khalid J. Farooqui Tarannum Bano Manoj Khandelwal Harmandeep Gill Ambrish Mithal |
| author_facet | Mohammad Shafi Kuchay Khalid J. Farooqui Tarannum Bano Manoj Khandelwal Harmandeep Gill Ambrish Mithal |
| author_sort | Mohammad Shafi Kuchay |
| collection | DOAJ |
| description | SUMMARY Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as first-line therapy in four consecutive patients with acute pancreatitis secondary to hypertriglyceridemia. In a literature search, we revised almost all reports published to date of patients managed successfully with this combination. Heparin and insulin appear to be a safe, effective, and inexpensive first-line therapy for hypertriglyceridemia-associated acute pancreatitis. |
| first_indexed | 2024-04-12T05:52:48Z |
| format | Article |
| id | doaj.art-713074fcf9cc40ae8adc190861b16f68 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-12T05:52:48Z |
| publishDate | 2017-02-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-713074fcf9cc40ae8adc190861b16f682022-12-22T03:45:15ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922017-02-0161219820110.1590/2359-3997000000244S2359-39972017000200198Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature reviewMohammad Shafi KuchayKhalid J. FarooquiTarannum BanoManoj KhandelwalHarmandeep GillAmbrish MithalSUMMARY Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as first-line therapy in four consecutive patients with acute pancreatitis secondary to hypertriglyceridemia. In a literature search, we revised almost all reports published to date of patients managed successfully with this combination. Heparin and insulin appear to be a safe, effective, and inexpensive first-line therapy for hypertriglyceridemia-associated acute pancreatitis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200198&lng=en&tlng=en |
| spellingShingle | Mohammad Shafi Kuchay Khalid J. Farooqui Tarannum Bano Manoj Khandelwal Harmandeep Gill Ambrish Mithal Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review Archives of Endocrinology and Metabolism |
| title | Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review |
| title_full | Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review |
| title_fullStr | Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review |
| title_full_unstemmed | Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review |
| title_short | Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review |
| title_sort | heparin and insulin in the management of hypertriglyceridemia associated pancreatitis case series and literature review |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200198&lng=en&tlng=en |
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