Tissue Damage in Radiation-Induced Oral Mucositis Is Mitigated by IL-17 Receptor Signaling

Tissue Damage in Radiation-Induced Oral Mucositis Is Mitigated by IL-17 Receptor Signaling

Oral mucositis (OM) is a treatment-limiting adverse side effect of radiation and chemotherapy. Approximately 80% of patients undergoing radiotherapy (RT) for head and neck cancers (HNC) develop OM, representing a major unmet medical condition. Our understanding of the immunopathogenesis of OM is lim...

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Bibliographic Details
Main Authors: Jessica Saul-McBeth, John Dillon, Aaron Lee, Dylan Launder, Jacqueline M. Kratch, Eanas Abutaha, Alexandria A. Williamson, Allen G. Schroering, Grace Michalski, Priosmita Biswas, Samuel R. Conti, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, E. Ishmael Parsai, Heather R. Conti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
oral mucositis (OM)
inflammation
interleukin-17
oral mucosa
healing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.687627/full

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