Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol
A new silver(I) cluster [Ag<sub>8</sub>L<sub>4</sub>(Py)(Pype)]·4Py·11H<sub>2</sub>O (<b>I</b>) with 3-benzyl-4-phenyl-1,2,4-triazol-5-thiol (L) was synthesized via the direct reaction of AgNO<sub>3</sub> and L in MeOH, followed by recrysta...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Online Access: | https://www.mdpi.com/1420-3049/29/1/105 |
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| author | Dmitriy S. Yambulatov Irina A. Lutsenko Dmitry E. Baravikov Fedor M. Dolgushin Tatiana V. Astaf’eva Olga B. Bekker Lusik G. Nersisyan Melanya A. Samvelyan Tariel V. Ghochikyan Mikhail A. Kiskin Igor L. Eremenko Vladimir K. Ivanov |
| author_facet | Dmitriy S. Yambulatov Irina A. Lutsenko Dmitry E. Baravikov Fedor M. Dolgushin Tatiana V. Astaf’eva Olga B. Bekker Lusik G. Nersisyan Melanya A. Samvelyan Tariel V. Ghochikyan Mikhail A. Kiskin Igor L. Eremenko Vladimir K. Ivanov |
| author_sort | Dmitriy S. Yambulatov |
| collection | DOAJ |
| description | A new silver(I) cluster [Ag<sub>8</sub>L<sub>4</sub>(Py)(Pype)]·4Py·11H<sub>2</sub>O (<b>I</b>) with 3-benzyl-4-phenyl-1,2,4-triazol-5-thiol (L) was synthesized via the direct reaction of AgNO<sub>3</sub> and L in MeOH, followed by recrystallization from a pyridine–piperidine mixture. The compound <b>I</b> was isolated in a monocrystal form and its crystal structure was determined via single crystal X-ray diffraction. The complex forms a “butterfly” cluster with triazol-5-thioles. The purity of the silver complex and its stability in the solution was confirmed via NMR analysis. Excitation and emission of the free ligand and its silver complex were studied at room temperature for solid samples. The in vitro biological activity of the free ligand and its complex was studied in relation to the non-pathogenic <i>Mycolicibacterium smegmatis</i> strain. Complexation of the free ligand with silver increases the biological activity of the former by almost twenty times. For the newly obtained silver cluster, a bactericidal effect was established. |
| first_indexed | 2024-03-08T15:01:22Z |
| format | Article |
| id | doaj.art-713297b561bc4c3e97aeef5b3df40154 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T15:01:22Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-713297b561bc4c3e97aeef5b3df401542024-01-10T15:04:09ZengMDPI AGMolecules1420-30492023-12-0129110510.3390/molecules29010105Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiolDmitriy S. Yambulatov0Irina A. Lutsenko1Dmitry E. Baravikov2Fedor M. Dolgushin3Tatiana V. Astaf’eva4Olga B. Bekker5Lusik G. Nersisyan6Melanya A. Samvelyan7Tariel V. Ghochikyan8Mikhail A. Kiskin9Igor L. Eremenko10Vladimir K. Ivanov11Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, RussiaVavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina, 3, 119333 Moscow, RussiaFaculty of Chemistry, Yerevan State University, 1 A Manoukyan Str., Yerevan 0025, ArmeniaFaculty of Chemistry, Yerevan State University, 1 A Manoukyan Str., Yerevan 0025, ArmeniaFaculty of Chemistry, Yerevan State University, 1 A Manoukyan Str., Yerevan 0025, ArmeniaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, RussiaA new silver(I) cluster [Ag<sub>8</sub>L<sub>4</sub>(Py)(Pype)]·4Py·11H<sub>2</sub>O (<b>I</b>) with 3-benzyl-4-phenyl-1,2,4-triazol-5-thiol (L) was synthesized via the direct reaction of AgNO<sub>3</sub> and L in MeOH, followed by recrystallization from a pyridine–piperidine mixture. The compound <b>I</b> was isolated in a monocrystal form and its crystal structure was determined via single crystal X-ray diffraction. The complex forms a “butterfly” cluster with triazol-5-thioles. The purity of the silver complex and its stability in the solution was confirmed via NMR analysis. Excitation and emission of the free ligand and its silver complex were studied at room temperature for solid samples. The in vitro biological activity of the free ligand and its complex was studied in relation to the non-pathogenic <i>Mycolicibacterium smegmatis</i> strain. Complexation of the free ligand with silver increases the biological activity of the former by almost twenty times. For the newly obtained silver cluster, a bactericidal effect was established.https://www.mdpi.com/1420-3049/29/1/1051,2,4-triazolesilvermolecular structureluminescencesingle crystalmetallodrugs |
| spellingShingle | Dmitriy S. Yambulatov Irina A. Lutsenko Dmitry E. Baravikov Fedor M. Dolgushin Tatiana V. Astaf’eva Olga B. Bekker Lusik G. Nersisyan Melanya A. Samvelyan Tariel V. Ghochikyan Mikhail A. Kiskin Igor L. Eremenko Vladimir K. Ivanov Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol Molecules 1,2,4-triazole silver molecular structure luminescence single crystal metallodrugs |
| title | Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol |
| title_full | Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol |
| title_fullStr | Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol |
| title_full_unstemmed | Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol |
| title_short | Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol |
| title_sort | synthesis structure biological activity and luminescence properties of a butterfly type silver cluster with 3 benzyl 4 phenyl 1 2 4 triazol 5 thiol |
| topic | 1,2,4-triazole silver molecular structure luminescence single crystal metallodrugs |
| url | https://www.mdpi.com/1420-3049/29/1/105 |
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