Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review
Abstract Chronic spontaneous urticaria (CSU) is a condition in which wheals, angioedema, and pruritus occur spontaneously and recurrently for at least 6 weeks. The etiology of this disease is partially dependent on production of autoantibodies that activate and recruit inflammatory cells. Although t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-06-01
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| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13555-023-00972-6 |
| _version_ | 1827890598893322240 |
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| author | Gil Yosipovitch Georgia Biazus Soares Omar Mahmoud |
| author_facet | Gil Yosipovitch Georgia Biazus Soares Omar Mahmoud |
| author_sort | Gil Yosipovitch |
| collection | DOAJ |
| description | Abstract Chronic spontaneous urticaria (CSU) is a condition in which wheals, angioedema, and pruritus occur spontaneously and recurrently for at least 6 weeks. The etiology of this disease is partially dependent on production of autoantibodies that activate and recruit inflammatory cells. Although the wheals can resolve within 24 h, symptoms have a significant detrimental impact on the quality of life of these patients. Standard therapy for CSU includes second-generation antihistamines and omalizumab. However, many patients tend to be refractory to these therapies. Available treatments such as cyclosporine, dapsone, dupilumab, and tumor necrosis factor alpha (TNFa) inhibitors have been used with success in some cases. Furthermore, various biologics and other novel drugs have emerged as potential treatments for this condition, and many more are currently under investigation in randomized clinical trials. |
| first_indexed | 2024-03-12T21:11:58Z |
| format | Article |
| id | doaj.art-7135729a0b5040a683b1c634d7a51538 |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-03-12T21:11:58Z |
| publishDate | 2023-06-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-7135729a0b5040a683b1c634d7a515382023-07-30T11:08:23ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722023-06-011381647166010.1007/s13555-023-00972-6Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative ReviewGil Yosipovitch0Georgia Biazus Soares1Omar Mahmoud2Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of MedicineDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of MedicineDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of MedicineAbstract Chronic spontaneous urticaria (CSU) is a condition in which wheals, angioedema, and pruritus occur spontaneously and recurrently for at least 6 weeks. The etiology of this disease is partially dependent on production of autoantibodies that activate and recruit inflammatory cells. Although the wheals can resolve within 24 h, symptoms have a significant detrimental impact on the quality of life of these patients. Standard therapy for CSU includes second-generation antihistamines and omalizumab. However, many patients tend to be refractory to these therapies. Available treatments such as cyclosporine, dapsone, dupilumab, and tumor necrosis factor alpha (TNFa) inhibitors have been used with success in some cases. Furthermore, various biologics and other novel drugs have emerged as potential treatments for this condition, and many more are currently under investigation in randomized clinical trials.https://doi.org/10.1007/s13555-023-00972-6Chronic spontaneous urticariaCSUPruritus |
| spellingShingle | Gil Yosipovitch Georgia Biazus Soares Omar Mahmoud Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review Dermatology and Therapy Chronic spontaneous urticaria CSU Pruritus |
| title | Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review |
| title_full | Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review |
| title_fullStr | Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review |
| title_full_unstemmed | Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review |
| title_short | Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review |
| title_sort | current and emerging therapies for chronic spontaneous urticaria a narrative review |
| topic | Chronic spontaneous urticaria CSU Pruritus |
| url | https://doi.org/10.1007/s13555-023-00972-6 |
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