Rheumatoid Arthritis Flare-ups Following Immunization with Sinopharm Inactivated Virus-based COVID-19 Vaccine
Introduction: This study aimed to investigate the incidence of rheumatoid arthritis (RA) flare-ups following immunization with the Sinopharm COVID-19 inactivated virus-based vaccine. Methods: We conducted a retrospective observational study at the Rheumatology Clinic of Imam Hossein Hospital, inc...
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2023-08-01
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| Series: | طب اورژانس ایران |
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| Online Access: | https://journals.sbmu.ac.ir/iranjem/article/view/42970 |
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| author | Parisa Delkash Amir Azimi Niloufar Taherpour Alireza Rajaei Faraneh Farsad Saeid Haji Aghajani |
| author_facet | Parisa Delkash Amir Azimi Niloufar Taherpour Alireza Rajaei Faraneh Farsad Saeid Haji Aghajani |
| author_sort | Parisa Delkash |
| collection | DOAJ |
| description |
Introduction: This study aimed to investigate the incidence of rheumatoid arthritis (RA) flare-ups following immunization with the Sinopharm COVID-19 inactivated virus-based vaccine.
Methods: We conducted a retrospective observational study at the Rheumatology Clinic of Imam Hossein Hospital, incorporating 200 RA patients in remission undergoing non-biologic Disease-Modifying Antirheumatic Drugs (DMARDs) treatments. A rheumatologist confirmed a flare-up based on patients complain of arthralgia and joint stiffness and complete examination of joints over a three-month period following vaccination.
Results: Twelve percent of all included patients experienced symptom recurrence. The average age of patients with flare-ups was significantly higher, but no gender-based differences were observed (p<0.001 and p=0.071, respectively). The second vaccine dose resulted in a higher number of symptom flares compared to the first dose (9.30% vs. 3.0%, p < 0.001). No significant differences were observed between patients experiencing flare-ups after the first dose and the second dose in terms of the number of involved joints (p=0.321) and the time gap from vaccination to symptom recurrence (p=0.526). No patients required hospitalization, and prednisolone dosage adjustments effectively managed symptoms.
Conclusion: The occurrence of flare-ups was relatively low after the Sinopharm COVID-19 vaccination in RA patients undergoing treatment with DMARDs during remission. The majority of these flares were mild and no hospitalizations were required.
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| first_indexed | 2024-03-12T11:55:45Z |
| format | Article |
| id | doaj.art-7137cbade9fe4acdbdcb76cdba89214c |
| institution | Directory Open Access Journal |
| issn | 2383-3645 |
| language | English |
| last_indexed | 2024-03-12T11:55:45Z |
| publishDate | 2023-08-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | طب اورژانس ایران |
| spelling | doaj.art-7137cbade9fe4acdbdcb76cdba89214c2023-08-31T03:34:09ZengShahid Beheshti University of Medical Sciencesطب اورژانس ایران2383-36452023-08-0110110.22037/ijem.v10i1.42970Rheumatoid Arthritis Flare-ups Following Immunization with Sinopharm Inactivated Virus-based COVID-19 VaccineParisa Delkash0Amir Azimi1Niloufar Taherpour 2Alireza Rajaei 3Faraneh Farsad 4Saeid Haji Aghajani 5Department of adult rheumatology, school of medicine, Imam Hossein hospital, Shahid Beheshti university of medical sciences, Tehran, Iran.Rajaie Cardiovascular Medical and Research Center, Iran university of medical sciences, Tehran,IranPrevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of rheumatology, Loghman Hakim hospital, Shahid Beheshti university of medical sciences, Tehran, IranDepartment of rheumatology, Loghman Hakim hospital, Shahid Beheshti university of medical sciences, Tehran, Iran. Department of internal medicine, Imam Hossein hospital, Shahid Beheshti university of medical sciences, Tehran, Iran Introduction: This study aimed to investigate the incidence of rheumatoid arthritis (RA) flare-ups following immunization with the Sinopharm COVID-19 inactivated virus-based vaccine. Methods: We conducted a retrospective observational study at the Rheumatology Clinic of Imam Hossein Hospital, incorporating 200 RA patients in remission undergoing non-biologic Disease-Modifying Antirheumatic Drugs (DMARDs) treatments. A rheumatologist confirmed a flare-up based on patients complain of arthralgia and joint stiffness and complete examination of joints over a three-month period following vaccination. Results: Twelve percent of all included patients experienced symptom recurrence. The average age of patients with flare-ups was significantly higher, but no gender-based differences were observed (p<0.001 and p=0.071, respectively). The second vaccine dose resulted in a higher number of symptom flares compared to the first dose (9.30% vs. 3.0%, p < 0.001). No significant differences were observed between patients experiencing flare-ups after the first dose and the second dose in terms of the number of involved joints (p=0.321) and the time gap from vaccination to symptom recurrence (p=0.526). No patients required hospitalization, and prednisolone dosage adjustments effectively managed symptoms. Conclusion: The occurrence of flare-ups was relatively low after the Sinopharm COVID-19 vaccination in RA patients undergoing treatment with DMARDs during remission. The majority of these flares were mild and no hospitalizations were required. https://journals.sbmu.ac.ir/iranjem/article/view/42970Rheumatoid arthritisCOVID-19SinopharmFlare-ups |
| spellingShingle | Parisa Delkash Amir Azimi Niloufar Taherpour Alireza Rajaei Faraneh Farsad Saeid Haji Aghajani Rheumatoid Arthritis Flare-ups Following Immunization with Sinopharm Inactivated Virus-based COVID-19 Vaccine طب اورژانس ایران Rheumatoid arthritis COVID-19 Sinopharm Flare-ups |
| title | Rheumatoid Arthritis Flare-ups Following Immunization with Sinopharm Inactivated Virus-based COVID-19 Vaccine |
| title_full | Rheumatoid Arthritis Flare-ups Following Immunization with Sinopharm Inactivated Virus-based COVID-19 Vaccine |
| title_fullStr | Rheumatoid Arthritis Flare-ups Following Immunization with Sinopharm Inactivated Virus-based COVID-19 Vaccine |
| title_full_unstemmed | Rheumatoid Arthritis Flare-ups Following Immunization with Sinopharm Inactivated Virus-based COVID-19 Vaccine |
| title_short | Rheumatoid Arthritis Flare-ups Following Immunization with Sinopharm Inactivated Virus-based COVID-19 Vaccine |
| title_sort | rheumatoid arthritis flare ups following immunization with sinopharm inactivated virus based covid 19 vaccine |
| topic | Rheumatoid arthritis COVID-19 Sinopharm Flare-ups |
| url | https://journals.sbmu.ac.ir/iranjem/article/view/42970 |
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