Role of Perilesional Sampling of Patients Undergoing Fusion Prostate Biopsies
Recently, researchers have proposed perilesional sampling during prostate biopsies to avoid systematic biopsies of patients at risk of prostate cancer. The aim of our study is to evaluate the role of perilesional sampling to avoid systematic biopsies of patients undergoing fusion biopsies. A prospec...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/8/1719 |
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| author | Riccardo Lombardo Giorgia Tema Antonio Nacchia Elisa Mancini Sara Franco Filippo Zammitti Antonio Franco Hannes Cash Carmen Gravina Alessio Guidotti Giacomo Gallo Nicola Ghezzo Antonio Cicione Andrea Tubaro Riccardo Autorino Cosimo De Nunzio |
| author_facet | Riccardo Lombardo Giorgia Tema Antonio Nacchia Elisa Mancini Sara Franco Filippo Zammitti Antonio Franco Hannes Cash Carmen Gravina Alessio Guidotti Giacomo Gallo Nicola Ghezzo Antonio Cicione Andrea Tubaro Riccardo Autorino Cosimo De Nunzio |
| author_sort | Riccardo Lombardo |
| collection | DOAJ |
| description | Recently, researchers have proposed perilesional sampling during prostate biopsies to avoid systematic biopsies of patients at risk of prostate cancer. The aim of our study is to evaluate the role of perilesional sampling to avoid systematic biopsies of patients undergoing fusion biopsies. A prospective cohort of patients undergoing transrectal MRI transrectal fusion biopsies were consecutively enrolled. All the patients underwent systematic biopsies (SB), targeted biopsies (TB) and perilesional biopsies within 10 mm from the lesion (PB). The detection rates of different strategies were determined. A total of 262 patients were enrolled. The median age of those enrolled was 70 years. The mean BMI was 27 kg/m<sup>2</sup>, and the mean and prostate volume was 52 mL. A PIRADS score ≥ 4 was recorded in 163/262 (40%) patients. Overall, the detection rates of cancer were 43.5% (114/262) and 35% (92/262) for csPCa. The use of the target + peri-target strategy resulted in a detection of 32.8% (86/262) of cancer cases and of 29% (76/262) of csPCa cases (Grade Group > 2). Using the target plus peri-target approach resulted in us missing 18/262 (7%) of the csPCa cases, avoiding the diagnosis of 8/262 (3%) of nsPCa cases. A biopsy strategy including lesional and perilesional sampling could avoid unnecessary prostate biopsies. However, the risk of missing significant cancers is present. Future studies should assess the cost–benefit relationship of different strategies. |
| first_indexed | 2024-03-10T23:47:34Z |
| format | Article |
| id | doaj.art-713943feb11b49e2905859ad341d2bc7 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T23:47:34Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-713943feb11b49e2905859ad341d2bc72023-11-19T01:54:37ZengMDPI AGLife2075-17292023-08-01138171910.3390/life13081719Role of Perilesional Sampling of Patients Undergoing Fusion Prostate BiopsiesRiccardo Lombardo0Giorgia Tema1Antonio Nacchia2Elisa Mancini3Sara Franco4Filippo Zammitti5Antonio Franco6Hannes Cash7Carmen Gravina8Alessio Guidotti9Giacomo Gallo10Nicola Ghezzo11Antonio Cicione12Andrea Tubaro13Riccardo Autorino14Cosimo De Nunzio15Ospedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Urology, University of Magdeburg, 39106 Magdeburg, GermanyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Urology, University of Chicago, Chicago, IL 60637, USAOspedale Sant’Andrea, Sapienza University of Rome, 00185 Rome, ItalyRecently, researchers have proposed perilesional sampling during prostate biopsies to avoid systematic biopsies of patients at risk of prostate cancer. The aim of our study is to evaluate the role of perilesional sampling to avoid systematic biopsies of patients undergoing fusion biopsies. A prospective cohort of patients undergoing transrectal MRI transrectal fusion biopsies were consecutively enrolled. All the patients underwent systematic biopsies (SB), targeted biopsies (TB) and perilesional biopsies within 10 mm from the lesion (PB). The detection rates of different strategies were determined. A total of 262 patients were enrolled. The median age of those enrolled was 70 years. The mean BMI was 27 kg/m<sup>2</sup>, and the mean and prostate volume was 52 mL. A PIRADS score ≥ 4 was recorded in 163/262 (40%) patients. Overall, the detection rates of cancer were 43.5% (114/262) and 35% (92/262) for csPCa. The use of the target + peri-target strategy resulted in a detection of 32.8% (86/262) of cancer cases and of 29% (76/262) of csPCa cases (Grade Group > 2). Using the target plus peri-target approach resulted in us missing 18/262 (7%) of the csPCa cases, avoiding the diagnosis of 8/262 (3%) of nsPCa cases. A biopsy strategy including lesional and perilesional sampling could avoid unnecessary prostate biopsies. However, the risk of missing significant cancers is present. Future studies should assess the cost–benefit relationship of different strategies.https://www.mdpi.com/2075-1729/13/8/1719prostate biopsyperilesional samplingtargeted biopsies |
| spellingShingle | Riccardo Lombardo Giorgia Tema Antonio Nacchia Elisa Mancini Sara Franco Filippo Zammitti Antonio Franco Hannes Cash Carmen Gravina Alessio Guidotti Giacomo Gallo Nicola Ghezzo Antonio Cicione Andrea Tubaro Riccardo Autorino Cosimo De Nunzio Role of Perilesional Sampling of Patients Undergoing Fusion Prostate Biopsies Life prostate biopsy perilesional sampling targeted biopsies |
| title | Role of Perilesional Sampling of Patients Undergoing Fusion Prostate Biopsies |
| title_full | Role of Perilesional Sampling of Patients Undergoing Fusion Prostate Biopsies |
| title_fullStr | Role of Perilesional Sampling of Patients Undergoing Fusion Prostate Biopsies |
| title_full_unstemmed | Role of Perilesional Sampling of Patients Undergoing Fusion Prostate Biopsies |
| title_short | Role of Perilesional Sampling of Patients Undergoing Fusion Prostate Biopsies |
| title_sort | role of perilesional sampling of patients undergoing fusion prostate biopsies |
| topic | prostate biopsy perilesional sampling targeted biopsies |
| url | https://www.mdpi.com/2075-1729/13/8/1719 |
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