Prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma: a systematic review and meta-analysis
Jie Shen,* Zhen Chen,* Min Fan, Hao Lu, Qianfeng Zhuang, Xiaozhou HeDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China*These authors contributed equally to this work Background: In recent years, inflammation has become w...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-06-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/prognostic-value-of-pretreatment-neutrophil-count-in-metastatic-renal--peer-reviewed-article-CMAR |
| _version_ | 1811230369585823744 |
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| author | Shen J Chen Z Fan M Lu H Zhuang Q He X |
| author_facet | Shen J Chen Z Fan M Lu H Zhuang Q He X |
| author_sort | Shen J |
| collection | DOAJ |
| description | Jie Shen,* Zhen Chen,* Min Fan, Hao Lu, Qianfeng Zhuang, Xiaozhou HeDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China*These authors contributed equally to this work Background: In recent years, inflammation has become widely recognized as a crucial component in tumor development and progression. Neutrophils are one of the most common inflammatory markers during hematological examinations. The prognostic value of neutrophils in metastatic renal cell carcinoma (mRCC) remains inconsistent. The aim of this meta-analysis is to evaluate the prognostic value of pretreatment neutrophil count in patients with mRCC.Methods: PubMed, Web of Science and Embase were searched for data on the association between pretreatment neutrophil count and mRCC prognosis up to October 7, 2017. We sorted out relevant studies and extracted the hazard ratio (HR) and its 95% confidence interval (CI) for overall survival (OS) and progression-free survival (PFS).Results: A total of 13 studies containing 3,021 patients with mRCC were summarized in the present meta-analysis. An elevated pretreatment neutrophil count yielded a worse OS (HR=2.17, 95% CI=1.68–2.79, P<0.001) and PFS (HR=1.78, 95% CI=0.91–3.49, P<0.001). Furthermore, we performed a subgroup analysis based on cut-off value, ethnicity, treatment method and analysis type. As a result, the association between pretreatment neutrophil count and survival was statistically significant in the subgroups of cut-off value, ethnicity, treatment method and analysis type.Conclusion: Our results show that the pretreatment neutrophil count is associated with mRCC outcomes and can be used as a valuable inflammatory marker for prognosis monitoring.Keywords: neutrophils, clear-cell metastatic renal cell carcinoma, prognosis, meta-analysis
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| first_indexed | 2024-04-12T10:28:20Z |
| format | Article |
| id | doaj.art-713af0cbad0a449091c79cd1ad54cb8a |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-12T10:28:20Z |
| publishDate | 2019-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-713af0cbad0a449091c79cd1ad54cb8a2022-12-22T03:36:55ZengDove Medical PressCancer Management and Research1179-13222019-06-01Volume 115365537446373Prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma: a systematic review and meta-analysisShen JChen ZFan MLu HZhuang QHe XJie Shen,* Zhen Chen,* Min Fan, Hao Lu, Qianfeng Zhuang, Xiaozhou HeDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China*These authors contributed equally to this work Background: In recent years, inflammation has become widely recognized as a crucial component in tumor development and progression. Neutrophils are one of the most common inflammatory markers during hematological examinations. The prognostic value of neutrophils in metastatic renal cell carcinoma (mRCC) remains inconsistent. The aim of this meta-analysis is to evaluate the prognostic value of pretreatment neutrophil count in patients with mRCC.Methods: PubMed, Web of Science and Embase were searched for data on the association between pretreatment neutrophil count and mRCC prognosis up to October 7, 2017. We sorted out relevant studies and extracted the hazard ratio (HR) and its 95% confidence interval (CI) for overall survival (OS) and progression-free survival (PFS).Results: A total of 13 studies containing 3,021 patients with mRCC were summarized in the present meta-analysis. An elevated pretreatment neutrophil count yielded a worse OS (HR=2.17, 95% CI=1.68–2.79, P<0.001) and PFS (HR=1.78, 95% CI=0.91–3.49, P<0.001). Furthermore, we performed a subgroup analysis based on cut-off value, ethnicity, treatment method and analysis type. As a result, the association between pretreatment neutrophil count and survival was statistically significant in the subgroups of cut-off value, ethnicity, treatment method and analysis type.Conclusion: Our results show that the pretreatment neutrophil count is associated with mRCC outcomes and can be used as a valuable inflammatory marker for prognosis monitoring.Keywords: neutrophils, clear-cell metastatic renal cell carcinoma, prognosis, meta-analysis https://www.dovepress.com/prognostic-value-of-pretreatment-neutrophil-count-in-metastatic-renal--peer-reviewed-article-CMARNeutrophilsClear-cell metastatic renal cell carcinomaPrognosisMeta-analysis |
| spellingShingle | Shen J Chen Z Fan M Lu H Zhuang Q He X Prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma: a systematic review and meta-analysis Cancer Management and Research Neutrophils Clear-cell metastatic renal cell carcinoma Prognosis Meta-analysis |
| title | Prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma: a systematic review and meta-analysis |
| title_full | Prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma: a systematic review and meta-analysis |
| title_fullStr | Prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma: a systematic review and meta-analysis |
| title_short | Prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma: a systematic review and meta-analysis |
| title_sort | prognostic value of pretreatment neutrophil count in metastatic renal cell carcinoma a systematic review and meta analysis |
| topic | Neutrophils Clear-cell metastatic renal cell carcinoma Prognosis Meta-analysis |
| url | https://www.dovepress.com/prognostic-value-of-pretreatment-neutrophil-count-in-metastatic-renal--peer-reviewed-article-CMAR |
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