Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial
Abstract Background Transcranial direct current stimulation (tDCS) has the potential to modulate cortical excitability and enhance the effects of walking training in people with Parkinson’s disease. This study will examine the efficacy of the addition of tDCS to a task-specific walking training to i...
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Trials |
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| Online Access: | https://doi.org/10.1186/s13063-021-05603-z |
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| author | Lucas Rodrigues Nascimento Ester Miyuki Nakamura-Palacios Augusto Boening Daniel Lyrio Cabral Alessandra Swarowsky Guilherme Peixoto Tinoco Arêas Wellingson Silva Paiva Fernando Zanela da Silva Arêas |
| author_facet | Lucas Rodrigues Nascimento Ester Miyuki Nakamura-Palacios Augusto Boening Daniel Lyrio Cabral Alessandra Swarowsky Guilherme Peixoto Tinoco Arêas Wellingson Silva Paiva Fernando Zanela da Silva Arêas |
| author_sort | Lucas Rodrigues Nascimento |
| collection | DOAJ |
| description | Abstract Background Transcranial direct current stimulation (tDCS) has the potential to modulate cortical excitability and enhance the effects of walking training in people with Parkinson’s disease. This study will examine the efficacy of the addition of tDCS to a task-specific walking training to improve walking and mobility and to reduce falls in people with Parkinson’s disease. Methods This is a two-arm, prospectively registered, randomized trial with concealed allocation, blinded assessors, participants and therapists, and intention-to-treat analysis. Twenty-four individuals with Parkinson’s disease, categorized as slow or intermediate walkers (walking speeds ≤ 1.0 m/s), will be recruited. The experimental group will undertake a 30-min walking training associated with tDCS, for 4 weeks. The control group will undertake the same walking training, but with sham-tDCS. The primary outcome will be comfortable walking speed. Secondary outcomes will include walking step length, walking cadence, walking confidence, mobility, freezing of gait, fear of falling, and falls. Outcomes will be collected by a researcher blinded to group allocation at baseline (week 0), after intervention (week 4), and 1 month beyond intervention (week 8). Discussion tDCS associated with walking training may help improve walking of slow and intermediate walkers with Parkinson’s disease. If walking is enhanced, the benefits may be accompanied by better mobility and reduced fear of falling, and individuals may experience greater free-living physical activity at home and in the community. Trial registration Brazilian Registry of Clinical Trials (ReBEC) RBR-6bvnx6 . Registered on September 23, 2019 |
| first_indexed | 2024-12-16T17:38:03Z |
| format | Article |
| id | doaj.art-713bd9cfee9041218e871e348c7de04d |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-16T17:38:03Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-713bd9cfee9041218e871e348c7de04d2022-12-21T22:22:40ZengBMCTrials1745-62152021-09-012211710.1186/s13063-021-05603-zTranscranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trialLucas Rodrigues Nascimento0Ester Miyuki Nakamura-Palacios1Augusto Boening2Daniel Lyrio Cabral3Alessandra Swarowsky4Guilherme Peixoto Tinoco Arêas5Wellingson Silva Paiva6Fernando Zanela da Silva Arêas7Center of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES)Laboratory of Cognitive Sciences and Neuropsychopharmacology, Department of Physiological Sciences, Universidade Federal do Espírito Santo (UFES)Center of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES)Center of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES)Department of Physical Therapy, Universidade Estadual de Santa Catarina (UDESC)Department of Human Physiology, Universidade Federal do Amazonas (UFAM)Neurosurgery Division, Department of Neurology, Clinical Hospital, Faculty of Medicine, University of São PauloCenter of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES)Abstract Background Transcranial direct current stimulation (tDCS) has the potential to modulate cortical excitability and enhance the effects of walking training in people with Parkinson’s disease. This study will examine the efficacy of the addition of tDCS to a task-specific walking training to improve walking and mobility and to reduce falls in people with Parkinson’s disease. Methods This is a two-arm, prospectively registered, randomized trial with concealed allocation, blinded assessors, participants and therapists, and intention-to-treat analysis. Twenty-four individuals with Parkinson’s disease, categorized as slow or intermediate walkers (walking speeds ≤ 1.0 m/s), will be recruited. The experimental group will undertake a 30-min walking training associated with tDCS, for 4 weeks. The control group will undertake the same walking training, but with sham-tDCS. The primary outcome will be comfortable walking speed. Secondary outcomes will include walking step length, walking cadence, walking confidence, mobility, freezing of gait, fear of falling, and falls. Outcomes will be collected by a researcher blinded to group allocation at baseline (week 0), after intervention (week 4), and 1 month beyond intervention (week 8). Discussion tDCS associated with walking training may help improve walking of slow and intermediate walkers with Parkinson’s disease. If walking is enhanced, the benefits may be accompanied by better mobility and reduced fear of falling, and individuals may experience greater free-living physical activity at home and in the community. Trial registration Brazilian Registry of Clinical Trials (ReBEC) RBR-6bvnx6 . Registered on September 23, 2019https://doi.org/10.1186/s13063-021-05603-zClinical trialParkinsonGaitTranscranial direct current stimulationRehabilitation |
| spellingShingle | Lucas Rodrigues Nascimento Ester Miyuki Nakamura-Palacios Augusto Boening Daniel Lyrio Cabral Alessandra Swarowsky Guilherme Peixoto Tinoco Arêas Wellingson Silva Paiva Fernando Zanela da Silva Arêas Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial Trials Clinical trial Parkinson Gait Transcranial direct current stimulation Rehabilitation |
| title | Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial |
| title_full | Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial |
| title_fullStr | Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial |
| title_full_unstemmed | Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial |
| title_short | Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial |
| title_sort | transcranial direct current stimulation tdcs in addition to walking training on walking mobility and reduction of falls in parkinson s disease study protocol for a randomized clinical trial |
| topic | Clinical trial Parkinson Gait Transcranial direct current stimulation Rehabilitation |
| url | https://doi.org/10.1186/s13063-021-05603-z |
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