Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors
Hussain I Saba, Duc Quang Tran, JrDepartment of Medicine, University of South Florida Medical Center, Tampa, FL, USAAbstract: In the past, patients with severe hemophilia have suffered a substantially reduced quality of life with frequent bleeding episodes, disabling arthropathy, and shorter life ex...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2012-05-01
|
| Series: | Journal of Blood Medicine |
| Online Access: | http://www.dovepress.com/challenges-and-successes-in-the-treatment-of-hemophilia-the-story-of-a-a9924 |
| _version_ | 1818532928134578176 |
|---|---|
| author | Saba HI Tran DQ Jr |
| author_facet | Saba HI Tran DQ Jr |
| author_sort | Saba HI |
| collection | DOAJ |
| description | Hussain I Saba, Duc Quang Tran, JrDepartment of Medicine, University of South Florida Medical Center, Tampa, FL, USAAbstract: In the past, patients with severe hemophilia have suffered a substantially reduced quality of life with frequent bleeding episodes, disabling arthropathy, and shorter life expectancy. In addition, methods of treatment and management have been costly and time-consuming, and have placed a considerable burden on patients' physical and psychological well-being. With the advent of the on-demand therapy and prophylactic treatment paradigm, patients have been able to receive care with less interruption of daily activities. Treatments may be more challenging for hemophiliacs with inhibitors to replacement factor; however, recent advances in the use of bypassing agents and immune tolerance therapy have enabled them to aggressively manage their disease while maintaining their independence. This review focuses on the challenges of treating such a severe hemophiliac through examination of the lifetime experience of a young adult male with a severe form of congenital hemophilia A. At this stage of his life, the patient has minimal disabilities and is inhibitor-free through optimal care and strong family support. His aspiration to pursue a productive life has led him to a career in medicine. After receiving his medical degree, he pursued a specialty in the treatment of hemophilia. By assisting other hemophilia patients, he exemplifies both the rewards of persevering through episodes of bleeding and other complications and the fact that disabilities can be minimized when managed meticulously and in a timely fashion to enable a productive and dignified life.Keywords: hemophilia, quality of life, factor VIII inhibitors, hemophilia treatment center, early treatment, bypassing agent |
| first_indexed | 2024-12-11T17:51:56Z |
| format | Article |
| id | doaj.art-713d55e471894dbb8ecf6ef128630bf3 |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-12-11T17:51:56Z |
| publishDate | 2012-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-713d55e471894dbb8ecf6ef128630bf32022-12-22T00:56:11ZengDove Medical PressJournal of Blood Medicine1179-27362012-05-012012default1723Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitorsSaba HITran DQ JrHussain I Saba, Duc Quang Tran, JrDepartment of Medicine, University of South Florida Medical Center, Tampa, FL, USAAbstract: In the past, patients with severe hemophilia have suffered a substantially reduced quality of life with frequent bleeding episodes, disabling arthropathy, and shorter life expectancy. In addition, methods of treatment and management have been costly and time-consuming, and have placed a considerable burden on patients' physical and psychological well-being. With the advent of the on-demand therapy and prophylactic treatment paradigm, patients have been able to receive care with less interruption of daily activities. Treatments may be more challenging for hemophiliacs with inhibitors to replacement factor; however, recent advances in the use of bypassing agents and immune tolerance therapy have enabled them to aggressively manage their disease while maintaining their independence. This review focuses on the challenges of treating such a severe hemophiliac through examination of the lifetime experience of a young adult male with a severe form of congenital hemophilia A. At this stage of his life, the patient has minimal disabilities and is inhibitor-free through optimal care and strong family support. His aspiration to pursue a productive life has led him to a career in medicine. After receiving his medical degree, he pursued a specialty in the treatment of hemophilia. By assisting other hemophilia patients, he exemplifies both the rewards of persevering through episodes of bleeding and other complications and the fact that disabilities can be minimized when managed meticulously and in a timely fashion to enable a productive and dignified life.Keywords: hemophilia, quality of life, factor VIII inhibitors, hemophilia treatment center, early treatment, bypassing agenthttp://www.dovepress.com/challenges-and-successes-in-the-treatment-of-hemophilia-the-story-of-a-a9924 |
| spellingShingle | Saba HI Tran DQ Jr Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors Journal of Blood Medicine |
| title | Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors |
| title_full | Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors |
| title_fullStr | Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors |
| title_full_unstemmed | Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors |
| title_short | Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors |
| title_sort | challenges and successes in the treatment of hemophilia the story of a patient with severe hemophilia a and high titer inhibitors |
| url | http://www.dovepress.com/challenges-and-successes-in-the-treatment-of-hemophilia-the-story-of-a-a9924 |
| work_keys_str_mv | AT sabahi challengesandsuccessesinthetreatmentofhemophiliathestoryofapatientwithseverehemophiliaaandhightiterinhibitors AT trandqjr challengesandsuccessesinthetreatmentofhemophiliathestoryofapatientwithseverehemophiliaaandhightiterinhibitors |