Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions

Objective MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still con...

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Main Authors: Yu-Long Wang, Wen Yu
Format: Article
Language:English
Published: PeerJ Inc. 2018-07-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/5218.pdf
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author Yu-Long Wang
Wen Yu
author_facet Yu-Long Wang
Wen Yu
author_sort Yu-Long Wang
collection DOAJ
description Objective MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still controversial. We therefore investigated the association between miR-122 expression and presence and severity of coronary atherosclerotic plaque. Methods During January–November 2017, we included 300 patients with coronary heart disease (CHD) and 100 subjects as the control group. MiR-122 content was detected by quantitative real-time polymerase chain reaction. MiR-122 level was identified in all subjects, and the Spearman correlation between miR-122 and severity of atherosclerosis was analyzed. Results Patients with CHD had higher miR-122 expression than in control group (2.61, 0.91–8.86 vs. 1.62, 0.71–3.45, p < 0.001). Gensini score was significantly associated with miR-122 expression (r = 0.7964, p < 0.001). The odds ratio of miR-122 solely was 0.12 (95% CI [0.05–0.43]) and factors such as cholesterol, triglyceride together with miR-122 level were closely associated with atherosclerosis (all p < 0.001). Conclusions The serum level of miR-122 may be used to differentiate between mild and severe coronary atherosclerotic lesion. Use of this marker might allow non-invasive diagnosis the degree of coronary atherosclerosis.
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spelling doaj.art-713dcd75dc9d44c8857c97805713c5df2023-12-03T11:06:06ZengPeerJ Inc.PeerJ2167-83592018-07-016e521810.7717/peerj.5218Association of circulating microRNA-122 with presence and severity of atherosclerotic lesionsYu-Long Wang0Wen Yu1Department of Cardiology, Haiyan People’s Hospital, Haiyan, Zhejiang, ChinaDepartment of Geriatric, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, ChinaObjective MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still controversial. We therefore investigated the association between miR-122 expression and presence and severity of coronary atherosclerotic plaque. Methods During January–November 2017, we included 300 patients with coronary heart disease (CHD) and 100 subjects as the control group. MiR-122 content was detected by quantitative real-time polymerase chain reaction. MiR-122 level was identified in all subjects, and the Spearman correlation between miR-122 and severity of atherosclerosis was analyzed. Results Patients with CHD had higher miR-122 expression than in control group (2.61, 0.91–8.86 vs. 1.62, 0.71–3.45, p < 0.001). Gensini score was significantly associated with miR-122 expression (r = 0.7964, p < 0.001). The odds ratio of miR-122 solely was 0.12 (95% CI [0.05–0.43]) and factors such as cholesterol, triglyceride together with miR-122 level were closely associated with atherosclerosis (all p < 0.001). Conclusions The serum level of miR-122 may be used to differentiate between mild and severe coronary atherosclerotic lesion. Use of this marker might allow non-invasive diagnosis the degree of coronary atherosclerosis.https://peerj.com/articles/5218.pdfmicroRNA-122Coronary heart diseaseBiomarkerAtherosclerosis
spellingShingle Yu-Long Wang
Wen Yu
Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions
PeerJ
microRNA-122
Coronary heart disease
Biomarker
Atherosclerosis
title Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions
title_full Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions
title_fullStr Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions
title_full_unstemmed Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions
title_short Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions
title_sort association of circulating microrna 122 with presence and severity of atherosclerotic lesions
topic microRNA-122
Coronary heart disease
Biomarker
Atherosclerosis
url https://peerj.com/articles/5218.pdf
work_keys_str_mv AT yulongwang associationofcirculatingmicrorna122withpresenceandseverityofatheroscleroticlesions
AT wenyu associationofcirculatingmicrorna122withpresenceandseverityofatheroscleroticlesions