SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME
Abstract. Blood serum levels of cytokines (Il-1β, TNFα, IL-2, IL-4, IL-6, IL-8, IL-10, IL-20, IL-23), cytokine soluble receptors (SRp55 TNFα, SR IL-6), as well as markers of insulin resistance were studied in a group of male patients with primary gout. Increased levels of the above cytokines and d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/577 |
| _version_ | 1797198022395822080 |
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| author | N. N. Kushnarenko A. V. Govorin P. P. Tereshkov |
| author_facet | N. N. Kushnarenko A. V. Govorin P. P. Tereshkov |
| author_sort | N. N. Kushnarenko |
| collection | DOAJ |
| description | Abstract. Blood serum levels of cytokines (Il-1β, TNFα, IL-2, IL-4, IL-6, IL-8, IL-10, IL-20, IL-23), cytokine soluble receptors (SRp55 TNFα, SR IL-6), as well as markers of insulin resistance were studied in a group of male patients with primary gout. Increased levels of the above cytokines and deficiency of soluble IL-6 receptors in blood serum were most pronounced in gouty patients with insulin resistance syndrome. Close links were revealed between serum uric acid and insulin contents in gouty patients. Significant correlations were found between the levels of insulin, some cytokines (IL-4, IL-6, TNFα), and soluble receptors (SRp55 TNFα, SR IL-6), thus presuming a certain role of impaired cytokine profile for development of insulin resistance syndrome in such cohort of patients. (Med. Immunol., 2011, vol. 13, N 6, pp 627-630) |
| first_indexed | 2024-03-08T05:50:42Z |
| format | Article |
| id | doaj.art-713e881cd43d4d9ebcbd3e41b0eb95c9 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:15Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-713e881cd43d4d9ebcbd3e41b0eb95c92024-04-22T13:07:38ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0113662763010.15789/1563-0625-2011-6-627-630574SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROMEN. N. Kushnarenko0A. V. Govorin1P. P. Tereshkov2ГОУ ВПО Читинская государственная медицинская академия, г. ЧитаГОУ ВПО Читинская государственная медицинская академия, г. ЧитаНаучно-исследовательский институт медицинской экологии Читинской государственной медицинской академии, г. ЧитаAbstract. Blood serum levels of cytokines (Il-1β, TNFα, IL-2, IL-4, IL-6, IL-8, IL-10, IL-20, IL-23), cytokine soluble receptors (SRp55 TNFα, SR IL-6), as well as markers of insulin resistance were studied in a group of male patients with primary gout. Increased levels of the above cytokines and deficiency of soluble IL-6 receptors in blood serum were most pronounced in gouty patients with insulin resistance syndrome. Close links were revealed between serum uric acid and insulin contents in gouty patients. Significant correlations were found between the levels of insulin, some cytokines (IL-4, IL-6, TNFα), and soluble receptors (SRp55 TNFα, SR IL-6), thus presuming a certain role of impaired cytokine profile for development of insulin resistance syndrome in such cohort of patients. (Med. Immunol., 2011, vol. 13, N 6, pp 627-630)https://www.mimmun.ru/mimmun/article/view/577goutcytokinescytokine soluble receptorsinsulin resistance |
| spellingShingle | N. N. Kushnarenko A. V. Govorin P. P. Tereshkov SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME Медицинская иммунология gout cytokines cytokine soluble receptors insulin resistance |
| title | SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME |
| title_full | SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME |
| title_fullStr | SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME |
| title_full_unstemmed | SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME |
| title_short | SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME |
| title_sort | some features of cytokine profile in patients with gout and insulin resistance syndrome |
| topic | gout cytokines cytokine soluble receptors insulin resistance |
| url | https://www.mimmun.ru/mimmun/article/view/577 |
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