dCas9-Based PDGFR–β Activation ADSCs Accelerate Wound Healing in Diabetic Mice through Angiogenesis and ECM Remodeling

dCas9-Based PDGFR–β Activation ADSCs Accelerate Wound Healing in Diabetic Mice through Angiogenesis and ECM Remodeling

The chronic wound represents a serious disease characterized by a failure to heal damaged skin and surrounding soft tissue. Mesenchymal stem cells (MSCs) derived from adipose tissue (ADSCs) are a promising therapeutic strategy, but their heterogeneity may result in varying or insufficient therapeuti...

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Bibliographic Details
Main Authors: Yumeng Li, Deyong Li, Lu You, Tian Deng, Qiuyu Pang, Xiangmin Meng, Bingmei Zhu
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
chronic wounds
CRISPRa
PDGFR–β
ADSCs
extracellular matrix
angiogenesis
Online Access:https://www.mdpi.com/1422-0067/24/6/5949

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