Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells

Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells

Introduction: Human induced pluripotent stem cells (hiPSCs) are useful tools for reproducing neural development in vitro. However, each hiPSC line has a different ability to differentiate into specific lineages, known as differentiation propensity, resulting in reduced reproducibility and increased...

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Bibliographic Details
Main Authors: Asato Sekiya, Ken Takasawa, Yoshikazu Arai, Shin-ichi Horike, Hidenori Akutsu, Akihiro Umezawa, Koichiro Nishino
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Regenerative Therapy
Subjects:
Human iPSCs
Neural stem cells
DNA methylation
Differentiation propensity
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320422001122

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