Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquid
The enantioselective esterification of (R,S)-flurbiprofen catalyzed by Candida sp. lipase (CSL) (a cheap commercial lipase) was successfully conducted in ionic liquid (IL). The effects of the type of IL, alcohol, temperature, substrate molar ratio and enzyme concentration were investigated. Under op...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/17518253.2016.1265153 |
| _version_ | 1811281841986994176 |
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| author | Ruihong Zhao Xiaowen Zhang Lu Zheng Hong Xu Mei Li |
| author_facet | Ruihong Zhao Xiaowen Zhang Lu Zheng Hong Xu Mei Li |
| author_sort | Ruihong Zhao |
| collection | DOAJ |
| description | The enantioselective esterification of (R,S)-flurbiprofen catalyzed by Candida sp. lipase (CSL) (a cheap commercial lipase) was successfully conducted in ionic liquid (IL). The effects of the type of IL, alcohol, temperature, substrate molar ratio and enzyme concentration were investigated. Under optimal conditions (flurbiprofen (0.2 mmol), methanol (2 mmol), CSL (4 mg/mL), [BMIM][PF6] (5 mL), 50°C), CSL exhibited a satisfying enzyme performance (average enzyme activity, 261.5 μmol/g/h; E value, 20.3). The enzymatic esterification can be scaled up easily. Furthermore, CSL exhibited only a slight decrease in catalytic performance after six repetitions. This result demonstrated that this mild method has high potential for industrial production. |
| first_indexed | 2024-04-13T01:40:48Z |
| format | Article |
| id | doaj.art-71409002465346fe9576f100404f75b4 |
| institution | Directory Open Access Journal |
| issn | 1751-8253 1751-7192 |
| language | English |
| last_indexed | 2024-04-13T01:40:48Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj.art-71409002465346fe9576f100404f75b42022-12-22T03:08:10ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922017-01-01101232810.1080/17518253.2016.12651531265153Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquidRuihong Zhao0Xiaowen Zhang1Lu Zheng2Hong Xu3Mei Li4The first hospital of Jilin universityJilin UniversityJilin UniversityThe first hospital of Jilin universityThe first hospital of Jilin universityThe enantioselective esterification of (R,S)-flurbiprofen catalyzed by Candida sp. lipase (CSL) (a cheap commercial lipase) was successfully conducted in ionic liquid (IL). The effects of the type of IL, alcohol, temperature, substrate molar ratio and enzyme concentration were investigated. Under optimal conditions (flurbiprofen (0.2 mmol), methanol (2 mmol), CSL (4 mg/mL), [BMIM][PF6] (5 mL), 50°C), CSL exhibited a satisfying enzyme performance (average enzyme activity, 261.5 μmol/g/h; E value, 20.3). The enzymatic esterification can be scaled up easily. Furthermore, CSL exhibited only a slight decrease in catalytic performance after six repetitions. This result demonstrated that this mild method has high potential for industrial production.http://dx.doi.org/10.1080/17518253.2016.1265153Flurbiprofenlipaseionic liquidenantioselective esterification |
| spellingShingle | Ruihong Zhao Xiaowen Zhang Lu Zheng Hong Xu Mei Li Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquid Green Chemistry Letters and Reviews Flurbiprofen lipase ionic liquid enantioselective esterification |
| title | Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquid |
| title_full | Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquid |
| title_fullStr | Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquid |
| title_full_unstemmed | Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquid |
| title_short | Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquid |
| title_sort | enantioselective esterification of r s flurbiprofen catalyzed by lipase in ionic liquid |
| topic | Flurbiprofen lipase ionic liquid enantioselective esterification |
| url | http://dx.doi.org/10.1080/17518253.2016.1265153 |
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