Experience in managing patients with Churg-Strauss syndrome.
Our goal was to analyze the possibilities of improving the diagnostics of CSS and to improve the effectiveness of treatment according to the existing literature and our own experience of long-term care for patients with eosinophilic granulomatosis with polyangiitis or Churg-Strauss syndrome (CSS)....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dnipro State Medical University
2018-04-01
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| Series: | Medičnì Perspektivi |
| Subjects: | |
| Online Access: | http://journals.uran.ua/index.php/2307-0404/article/view/127252 |
| _version_ | 1819289201815846912 |
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| author | A. A. Khanyukov Т. V. Lakiza Т. А. Simonova L. S. Pryazhnikova V. Yu. Poleshko N. A. Romuz |
| author_facet | A. A. Khanyukov Т. V. Lakiza Т. А. Simonova L. S. Pryazhnikova V. Yu. Poleshko N. A. Romuz |
| author_sort | A. A. Khanyukov |
| collection | DOAJ |
| description | Our goal was to analyze the possibilities of improving the diagnostics of CSS and to improve the effectiveness of treatment according to the existing literature and our own experience of long-term care for patients with eosinophilic granulomatosis with polyangiitis or Churg-Strauss syndrome (CSS). The medical histories of three female patients aged 26 to 46-years and a 20-year-old male patient were considered. The duration of the disease before the established diagnosis was 5-17 years. Anamnesis and medical documents analysis showed a typical CSS debut in the form of allergic rhinitis, nasal polyps, which were recurrent after polypectomy, and respiratory disorders, which were regarded as bronchitis or bronchial asthma – corresponding to the first phase, also called the prodromal or allergic stage of CSS. The prodromal period lasts up to 10 years or more and is characterized by various allergic manifestations, more often – pollinosis or bronchial asthma, that is difficult to control. But CSS can be suspected because of low effectiveness of the therapy with inhaled steroids, lack of effect of antibiotics and eosinophilia more than 10% that occurs periodically. Even in the third stage of CSS in systemic manifestations of vasculitis and severe secondary lesions of organs and tissues with functional impairment, constant intake of maintenance doses of corticosteroids and cytostatics allows to achieve stabilization of the process in patients with CSS. |
| first_indexed | 2024-12-24T03:03:05Z |
| format | Article |
| id | doaj.art-71433720e742477e92419d42ed718488 |
| institution | Directory Open Access Journal |
| issn | 2307-0404 |
| language | English |
| last_indexed | 2024-12-24T03:03:05Z |
| publishDate | 2018-04-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj.art-71433720e742477e92419d42ed7184882022-12-21T17:18:07ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042018-04-01231(part1)13614010.26641/2307-0404.2018.1(part1).127252127252Experience in managing patients with Churg-Strauss syndrome.A. A. KhanyukovТ. V. LakizaТ. А. SimonovaL. S. PryazhnikovaV. Yu. PoleshkoN. A. RomuzOur goal was to analyze the possibilities of improving the diagnostics of CSS and to improve the effectiveness of treatment according to the existing literature and our own experience of long-term care for patients with eosinophilic granulomatosis with polyangiitis or Churg-Strauss syndrome (CSS). The medical histories of three female patients aged 26 to 46-years and a 20-year-old male patient were considered. The duration of the disease before the established diagnosis was 5-17 years. Anamnesis and medical documents analysis showed a typical CSS debut in the form of allergic rhinitis, nasal polyps, which were recurrent after polypectomy, and respiratory disorders, which were regarded as bronchitis or bronchial asthma – corresponding to the first phase, also called the prodromal or allergic stage of CSS. The prodromal period lasts up to 10 years or more and is characterized by various allergic manifestations, more often – pollinosis or bronchial asthma, that is difficult to control. But CSS can be suspected because of low effectiveness of the therapy with inhaled steroids, lack of effect of antibiotics and eosinophilia more than 10% that occurs periodically. Even in the third stage of CSS in systemic manifestations of vasculitis and severe secondary lesions of organs and tissues with functional impairment, constant intake of maintenance doses of corticosteroids and cytostatics allows to achieve stabilization of the process in patients with CSS.http://journals.uran.ua/index.php/2307-0404/article/view/127252Churg-Strauss syndromediagnosistreatment |
| spellingShingle | A. A. Khanyukov Т. V. Lakiza Т. А. Simonova L. S. Pryazhnikova V. Yu. Poleshko N. A. Romuz Experience in managing patients with Churg-Strauss syndrome. Medičnì Perspektivi Churg-Strauss syndrome diagnosis treatment |
| title | Experience in managing patients with Churg-Strauss syndrome. |
| title_full | Experience in managing patients with Churg-Strauss syndrome. |
| title_fullStr | Experience in managing patients with Churg-Strauss syndrome. |
| title_full_unstemmed | Experience in managing patients with Churg-Strauss syndrome. |
| title_short | Experience in managing patients with Churg-Strauss syndrome. |
| title_sort | experience in managing patients with churg strauss syndrome |
| topic | Churg-Strauss syndrome diagnosis treatment |
| url | http://journals.uran.ua/index.php/2307-0404/article/view/127252 |
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