Enterovirus A71 Vaccines
Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death. Vaccination is the most efficient way to control virus infection. There are currently three inactivated, whole EV-A...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/3/199 |
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| author | Mei-Ling Li Shin-Ru Shih Blanton S. Tolbert Gary Brewer |
| author_facet | Mei-Ling Li Shin-Ru Shih Blanton S. Tolbert Gary Brewer |
| author_sort | Mei-Ling Li |
| collection | DOAJ |
| description | Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death. Vaccination is the most efficient way to control virus infection. There are currently three inactivated, whole EV-A71 vaccines licensed by the China NMPA (National Medical Products Administration). Several other types of vaccines, such as virus-like particles and recombinant VP1 (capsid protein), are also under development. In this review, we discuss recent advances in the development of EV-A71 vaccines. |
| first_indexed | 2024-03-09T06:17:48Z |
| format | Article |
| id | doaj.art-7144eea79b2b49138a5c61555ffcf74f |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T06:17:48Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-7144eea79b2b49138a5c61555ffcf74f2023-12-03T11:51:54ZengMDPI AGVaccines2076-393X2021-02-019319910.3390/vaccines9030199Enterovirus A71 VaccinesMei-Ling Li0Shin-Ru Shih1Blanton S. Tolbert2Gary Brewer3Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USAResearch Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USADepartment of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USAEnterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death. Vaccination is the most efficient way to control virus infection. There are currently three inactivated, whole EV-A71 vaccines licensed by the China NMPA (National Medical Products Administration). Several other types of vaccines, such as virus-like particles and recombinant VP1 (capsid protein), are also under development. In this review, we discuss recent advances in the development of EV-A71 vaccines.https://www.mdpi.com/2076-393X/9/3/199Enterovirus A71handfoot and mouth disease (HFMD)vaccineSinovac |
| spellingShingle | Mei-Ling Li Shin-Ru Shih Blanton S. Tolbert Gary Brewer Enterovirus A71 Vaccines Vaccines Enterovirus A71 hand foot and mouth disease (HFMD) vaccine Sinovac |
| title | Enterovirus A71 Vaccines |
| title_full | Enterovirus A71 Vaccines |
| title_fullStr | Enterovirus A71 Vaccines |
| title_full_unstemmed | Enterovirus A71 Vaccines |
| title_short | Enterovirus A71 Vaccines |
| title_sort | enterovirus a71 vaccines |
| topic | Enterovirus A71 hand foot and mouth disease (HFMD) vaccine Sinovac |
| url | https://www.mdpi.com/2076-393X/9/3/199 |
| work_keys_str_mv | AT meilingli enterovirusa71vaccines AT shinrushih enterovirusa71vaccines AT blantonstolbert enterovirusa71vaccines AT garybrewer enterovirusa71vaccines |