An updated overview of e-cigarette impact on human health

Abstract The electronic cigarette (e-cigarette), for many considered as a safe alternative to conventional cigarettes, has revolutionised the tobacco industry in the last decades. In e-cigarettes, tobacco combustion is replaced by e-liquid heating, leading some manufacturers to propose that e-cigare...

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Main Authors: Patrice Marques, Laura Piqueras, Maria-Jesus Sanz
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Respiratory Research
Subjects:
Online Access:https://doi.org/10.1186/s12931-021-01737-5
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author Patrice Marques
Laura Piqueras
Maria-Jesus Sanz
author_facet Patrice Marques
Laura Piqueras
Maria-Jesus Sanz
author_sort Patrice Marques
collection DOAJ
description Abstract The electronic cigarette (e-cigarette), for many considered as a safe alternative to conventional cigarettes, has revolutionised the tobacco industry in the last decades. In e-cigarettes, tobacco combustion is replaced by e-liquid heating, leading some manufacturers to propose that e-cigarettes have less harmful respiratory effects than tobacco consumption. Other innovative features such as the adjustment of nicotine content and the choice of pleasant flavours have won over many users. Nevertheless, the safety of e-cigarette consumption and its potential as a smoking cessation method remain controversial due to limited evidence. Moreover, it has been reported that the heating process itself can lead to the formation of new decomposition compounds of questionable toxicity. Numerous in vivo and in vitro studies have been performed to better understand the impact of these new inhalable compounds on human health. Results of toxicological analyses suggest that e-cigarettes can be safer than conventional cigarettes, although harmful effects from short-term e-cigarette use have been described. Worryingly, the potential long-term effects of e-cigarette consumption have been scarcely investigated. In this review, we take stock of the main findings in this field and their consequences for human health including coronavirus disease 2019 (COVID-19).
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spelling doaj.art-7145796aa0c7475d98aaa984f234873d2022-12-21T22:32:45ZengBMCRespiratory Research1465-993X2021-05-0122111410.1186/s12931-021-01737-5An updated overview of e-cigarette impact on human healthPatrice Marques0Laura Piqueras1Maria-Jesus Sanz2Department of Pharmacology, Faculty of Medicine, University of ValenciaDepartment of Pharmacology, Faculty of Medicine, University of ValenciaDepartment of Pharmacology, Faculty of Medicine, University of ValenciaAbstract The electronic cigarette (e-cigarette), for many considered as a safe alternative to conventional cigarettes, has revolutionised the tobacco industry in the last decades. In e-cigarettes, tobacco combustion is replaced by e-liquid heating, leading some manufacturers to propose that e-cigarettes have less harmful respiratory effects than tobacco consumption. Other innovative features such as the adjustment of nicotine content and the choice of pleasant flavours have won over many users. Nevertheless, the safety of e-cigarette consumption and its potential as a smoking cessation method remain controversial due to limited evidence. Moreover, it has been reported that the heating process itself can lead to the formation of new decomposition compounds of questionable toxicity. Numerous in vivo and in vitro studies have been performed to better understand the impact of these new inhalable compounds on human health. Results of toxicological analyses suggest that e-cigarettes can be safer than conventional cigarettes, although harmful effects from short-term e-cigarette use have been described. Worryingly, the potential long-term effects of e-cigarette consumption have been scarcely investigated. In this review, we take stock of the main findings in this field and their consequences for human health including coronavirus disease 2019 (COVID-19).https://doi.org/10.1186/s12931-021-01737-5Electronic cigaretteE-cigaretteNicotineTobaccoHumectantsFlavourings
spellingShingle Patrice Marques
Laura Piqueras
Maria-Jesus Sanz
An updated overview of e-cigarette impact on human health
Respiratory Research
Electronic cigarette
E-cigarette
Nicotine
Tobacco
Humectants
Flavourings
title An updated overview of e-cigarette impact on human health
title_full An updated overview of e-cigarette impact on human health
title_fullStr An updated overview of e-cigarette impact on human health
title_full_unstemmed An updated overview of e-cigarette impact on human health
title_short An updated overview of e-cigarette impact on human health
title_sort updated overview of e cigarette impact on human health
topic Electronic cigarette
E-cigarette
Nicotine
Tobacco
Humectants
Flavourings
url https://doi.org/10.1186/s12931-021-01737-5
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