Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms include tremor, bradykinesia, rigidity, pain, and postural instability, with significa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | Bioelectronic Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s42234-020-00041-9 |
| _version_ | 1819150300254044160 |
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| author | Yi Cai Rajiv D. Reddy Vishal Varshney Krishnan V. Chakravarthy |
| author_facet | Yi Cai Rajiv D. Reddy Vishal Varshney Krishnan V. Chakravarthy |
| author_sort | Yi Cai |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms include tremor, bradykinesia, rigidity, pain, and postural instability, with significant impact in quality of life and mortality. To date there is ongoing research to determine the optimum therapy for PD. In this review we analyze the current data in the use of spinal cord stimulation (SCS) therapy for treatment for Parkinsonian symptoms. We specifically address waveform pattern, anatomic location and the role of spinal cord stimulation (SCS) as a salvage therapy after deep brain stimulation (DBS) therapy. We also outline current experimental evidence from preclinical research highlighting possible mechanisms of beneficial effects of SCS in this context. Though the use of SCS therapy is in its infancy for treatment of PD, the data points to an exciting area for ongoing research and exploration with positive outcomes from both cervical and thoracic tonic and BURSTDR spinal cord stimulation. |
| first_indexed | 2024-12-22T14:15:19Z |
| format | Article |
| id | doaj.art-714689d5bf054834bf016f94834aa64a |
| institution | Directory Open Access Journal |
| issn | 2332-8886 |
| language | English |
| last_indexed | 2024-12-22T14:15:19Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Bioelectronic Medicine |
| spelling | doaj.art-714689d5bf054834bf016f94834aa64a2022-12-21T18:23:08ZengBMCBioelectronic Medicine2332-88862020-03-016111010.1186/s42234-020-00041-9Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospectsYi Cai0Rajiv D. Reddy1Vishal Varshney2Krishnan V. Chakravarthy3Department of Anesthesiology and Pain Medicine, University of California San Diego Health SciencesDepartment of Anesthesiology and Pain Medicine, University of California San Diego Health SciencesDepartment of Anesthesiology, Perioperative and Pain Medicine, University of CalgaryDepartment of Anesthesiology and Pain Medicine, University of California San Diego Health SciencesAbstract Parkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms include tremor, bradykinesia, rigidity, pain, and postural instability, with significant impact in quality of life and mortality. To date there is ongoing research to determine the optimum therapy for PD. In this review we analyze the current data in the use of spinal cord stimulation (SCS) therapy for treatment for Parkinsonian symptoms. We specifically address waveform pattern, anatomic location and the role of spinal cord stimulation (SCS) as a salvage therapy after deep brain stimulation (DBS) therapy. We also outline current experimental evidence from preclinical research highlighting possible mechanisms of beneficial effects of SCS in this context. Though the use of SCS therapy is in its infancy for treatment of PD, the data points to an exciting area for ongoing research and exploration with positive outcomes from both cervical and thoracic tonic and BURSTDR spinal cord stimulation.http://link.springer.com/article/10.1186/s42234-020-00041-9NeuromodulationSpinal cord stimulationParkinson’s diseaseGaitSalvage therapy |
| spellingShingle | Yi Cai Rajiv D. Reddy Vishal Varshney Krishnan V. Chakravarthy Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects Bioelectronic Medicine Neuromodulation Spinal cord stimulation Parkinson’s disease Gait Salvage therapy |
| title | Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects |
| title_full | Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects |
| title_fullStr | Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects |
| title_full_unstemmed | Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects |
| title_short | Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects |
| title_sort | spinal cord stimulation in parkinson s disease a review of the preclinical and clinical data and future prospects |
| topic | Neuromodulation Spinal cord stimulation Parkinson’s disease Gait Salvage therapy |
| url | http://link.springer.com/article/10.1186/s42234-020-00041-9 |
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