Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia?
Chorioamnionitis is an inflammation in the fetal membranes or placenta. When chorioamnionitis develops, fetal lungs are exposed to inflammatory cytokines and mediators via amniotic fluid. Because inflammation plays a pivotal role in the development of bronchopulmonary dysplasia (BPD), a chronic lung...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Pediatric Society
2017-07-01
|
| Series: | Korean Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://kjp.or.kr/upload/pdf/kjped-60-203.pdf |
| _version_ | 1819150360584912896 |
|---|---|
| author | Chang Won Choi |
| author_facet | Chang Won Choi |
| author_sort | Chang Won Choi |
| collection | DOAJ |
| description | Chorioamnionitis is an inflammation in the fetal membranes or placenta. When chorioamnionitis develops, fetal lungs are exposed to inflammatory cytokines and mediators via amniotic fluid. Because inflammation plays a pivotal role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, fetal lung inflammation induced by chorioamnionitis has been considered to be one of the major pathogenetic factors for BPD. Although there have been a number of studies that demonstrated the relationship between chorioamnionitis and BPD, there are still controversies on this issue. The controversies on the relationship between chorioamnionitis and BPD arise from not-unified definitions of chorioamnionitis and BPD, different study populations, and the proportion of contribution between inflammation and infectious microorganisms. The publication bias also contributes to the controversies. Clinical trials targeting chorioamnionitis or microorganisms that cause chorioamnionitis will answer on the actual relationship between chorioamnionitis and BPD and provide a novel prophylactic strategy against BPD based on that relationship. |
| first_indexed | 2024-12-22T14:16:16Z |
| format | Article |
| id | doaj.art-714722179f634e2583cf341915277642 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-22T14:16:16Z |
| publishDate | 2017-07-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-714722179f634e2583cf3419152776422022-12-21T18:23:06ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582017-07-0160720320710.3345/kjp.2017.60.7.20320125550658Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia?Chang Won Choi0Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.Chorioamnionitis is an inflammation in the fetal membranes or placenta. When chorioamnionitis develops, fetal lungs are exposed to inflammatory cytokines and mediators via amniotic fluid. Because inflammation plays a pivotal role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, fetal lung inflammation induced by chorioamnionitis has been considered to be one of the major pathogenetic factors for BPD. Although there have been a number of studies that demonstrated the relationship between chorioamnionitis and BPD, there are still controversies on this issue. The controversies on the relationship between chorioamnionitis and BPD arise from not-unified definitions of chorioamnionitis and BPD, different study populations, and the proportion of contribution between inflammation and infectious microorganisms. The publication bias also contributes to the controversies. Clinical trials targeting chorioamnionitis or microorganisms that cause chorioamnionitis will answer on the actual relationship between chorioamnionitis and BPD and provide a novel prophylactic strategy against BPD based on that relationship.http://kjp.or.kr/upload/pdf/kjped-60-203.pdfChorioamnionitisBronchopulmonary dysplasiaUreaplasma |
| spellingShingle | Chang Won Choi Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? Korean Journal of Pediatrics Chorioamnionitis Bronchopulmonary dysplasia Ureaplasma |
| title | Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? |
| title_full | Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? |
| title_fullStr | Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? |
| title_full_unstemmed | Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? |
| title_short | Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? |
| title_sort | chorioamnionitis is a major player in the development of bronchopulmonary dysplasia |
| topic | Chorioamnionitis Bronchopulmonary dysplasia Ureaplasma |
| url | http://kjp.or.kr/upload/pdf/kjped-60-203.pdf |
| work_keys_str_mv | AT changwonchoi chorioamnionitisisamajorplayerinthedevelopmentofbronchopulmonarydysplasia |