C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor
Predators and prey co-evolve, each maximizing their own fitness, but the effects of predator–prey interactions on cellular and molecular machinery are poorly understood. Here, we study this process using the predator Caenorhabditis elegans and the bacterial prey Streptomyces, which have evolved a po...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2017-09-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/23770 |
| _version_ | 1818019830967566336 |
|---|---|
| author | Alan Tran Angelina Tang Colleen T O'Loughlin Anthony Balistreri Eric Chang Doris Coto Villa Joy Li Aruna Varshney Vanessa Jimenez Jacqueline Pyle Bryan Tsujimoto Christopher Wellbrook Christopher Vargas Alex Duong Nebat Ali Sarah Y Matthews Samantha Levinson Sarah Woldemariam Sami Khuri Martina Bremer Daryl K Eggers Noelle L'Etoile Laura C Miller Conrad Miri K VanHoven |
| author_facet | Alan Tran Angelina Tang Colleen T O'Loughlin Anthony Balistreri Eric Chang Doris Coto Villa Joy Li Aruna Varshney Vanessa Jimenez Jacqueline Pyle Bryan Tsujimoto Christopher Wellbrook Christopher Vargas Alex Duong Nebat Ali Sarah Y Matthews Samantha Levinson Sarah Woldemariam Sami Khuri Martina Bremer Daryl K Eggers Noelle L'Etoile Laura C Miller Conrad Miri K VanHoven |
| author_sort | Alan Tran |
| collection | DOAJ |
| description | Predators and prey co-evolve, each maximizing their own fitness, but the effects of predator–prey interactions on cellular and molecular machinery are poorly understood. Here, we study this process using the predator Caenorhabditis elegans and the bacterial prey Streptomyces, which have evolved a powerful defense: the production of nematicides. We demonstrate that upon exposure to Streptomyces at their head or tail, nematodes display an escape response that is mediated by bacterially produced cues. Avoidance requires a predicted G-protein-coupled receptor, SRB-6, which is expressed in five types of amphid and phasmid chemosensory neurons. We establish that species of Streptomyces secrete dodecanoic acid, which is sensed by SRB-6. This behavioral adaptation represents an important strategy for the nematode, which utilizes specialized sensory organs and a chemoreceptor that is tuned to recognize the bacteria. These findings provide a window into the molecules and organs used in the coevolutionary arms race between predator and potential prey. |
| first_indexed | 2024-04-14T07:56:46Z |
| format | Article |
| id | doaj.art-7147cdee9ba441cbb6a350654e6cf939 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:56:46Z |
| publishDate | 2017-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-7147cdee9ba441cbb6a350654e6cf9392022-12-22T02:05:01ZengeLife Sciences Publications LtdeLife2050-084X2017-09-01610.7554/eLife.23770C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptorAlan Tran0Angelina Tang1Colleen T O'Loughlin2Anthony Balistreri3Eric Chang4Doris Coto Villa5Joy Li6Aruna Varshney7Vanessa Jimenez8Jacqueline Pyle9Bryan Tsujimoto10Christopher Wellbrook11Christopher Vargas12Alex Duong13Nebat Ali14Sarah Y Matthews15Samantha Levinson16Sarah Woldemariam17Sami Khuri18Martina Bremer19Daryl K Eggers20Noelle L'Etoile21Laura C Miller Conrad22Miri K VanHoven23https://orcid.org/0000-0001-7714-1555Department of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United StatesDepartment of Chemistry, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesDepartment of Chemistry, San Jose State University, California, United StatesDepartment of Chemistry, San Jose State University, California, United StatesDepartment of Cell & Tissue Biology, University of California San Francisco, San Francisco, United StatesDepartment of Computer Science, San Jose State University, California, United StatesDepartment of Mathematics and Statistics, San Jose State University, California, United StatesDepartment of Chemistry, San Jose State University, California, United StatesDepartment of Cell & Tissue Biology, University of California San Francisco, San Francisco, United StatesDepartment of Chemistry, San Jose State University, California, United StatesDepartment of Biological Sciences, San Jose State University, California, United StatesPredators and prey co-evolve, each maximizing their own fitness, but the effects of predator–prey interactions on cellular and molecular machinery are poorly understood. Here, we study this process using the predator Caenorhabditis elegans and the bacterial prey Streptomyces, which have evolved a powerful defense: the production of nematicides. We demonstrate that upon exposure to Streptomyces at their head or tail, nematodes display an escape response that is mediated by bacterially produced cues. Avoidance requires a predicted G-protein-coupled receptor, SRB-6, which is expressed in five types of amphid and phasmid chemosensory neurons. We establish that species of Streptomyces secrete dodecanoic acid, which is sensed by SRB-6. This behavioral adaptation represents an important strategy for the nematode, which utilizes specialized sensory organs and a chemoreceptor that is tuned to recognize the bacteria. These findings provide a window into the molecules and organs used in the coevolutionary arms race between predator and potential prey.https://elifesciences.org/articles/23770predatorpreyStreptomycessrb-6dodecanoic acidphasmid |
| spellingShingle | Alan Tran Angelina Tang Colleen T O'Loughlin Anthony Balistreri Eric Chang Doris Coto Villa Joy Li Aruna Varshney Vanessa Jimenez Jacqueline Pyle Bryan Tsujimoto Christopher Wellbrook Christopher Vargas Alex Duong Nebat Ali Sarah Y Matthews Samantha Levinson Sarah Woldemariam Sami Khuri Martina Bremer Daryl K Eggers Noelle L'Etoile Laura C Miller Conrad Miri K VanHoven C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor eLife predator prey Streptomyces srb-6 dodecanoic acid phasmid |
| title | C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor |
| title_full | C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor |
| title_fullStr | C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor |
| title_full_unstemmed | C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor |
| title_short | C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor |
| title_sort | c elegans avoids toxin producing streptomyces using a seven transmembrane domain chemosensory receptor |
| topic | predator prey Streptomyces srb-6 dodecanoic acid phasmid |
| url | https://elifesciences.org/articles/23770 |
| work_keys_str_mv | AT alantran celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT angelinatang celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT colleentoloughlin celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT anthonybalistreri celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT ericchang celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT doriscotovilla celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT joyli celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT arunavarshney celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT vanessajimenez celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT jacquelinepyle celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT bryantsujimoto celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT christopherwellbrook celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT christophervargas celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT alexduong celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT nebatali celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT sarahymatthews celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT samanthalevinson celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT sarahwoldemariam celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT samikhuri celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT martinabremer celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT darylkeggers celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT noelleletoile celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT lauracmillerconrad celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor AT mirikvanhoven celegansavoidstoxinproducingstreptomycesusingaseventransmembranedomainchemosensoryreceptor |