Juvenile idiopathic epilepsy in Egyptian Arabian foals, a potential animal model of self‐limited epilepsy in children
Abstract Background Juvenile idiopathic epilepsy (JIE) is categorized as a generalized epilepsy. Epilepsy classification entails electrocortical characterization and localization of epileptic discharges (ED) using electroencephalography (EEG). Hypothesis/Objectives Characterize epilepsy in Egyptian...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16965 |
| _version_ | 1797349504834338816 |
|---|---|
| author | Monica Aleman Ruba Benini Sami Elestwani Tatiana Vinardell |
| author_facet | Monica Aleman Ruba Benini Sami Elestwani Tatiana Vinardell |
| author_sort | Monica Aleman |
| collection | DOAJ |
| description | Abstract Background Juvenile idiopathic epilepsy (JIE) is categorized as a generalized epilepsy. Epilepsy classification entails electrocortical characterization and localization of epileptic discharges (ED) using electroencephalography (EEG). Hypothesis/Objectives Characterize epilepsy in Egyptian Arabian foals with JIE using EEG. Animals Sixty‐nine foals (JIE, 48; controls, 21). Methods Retrospective study. Inclusion criteria consisted of Egyptian Arabian foals: (1) JIE group diagnosed based on witnessed or recorded seizures, and neurological and EEG findings, and (2) control group of healthy nonepileptic age‐matched foals. Clinical data were obtained in 48 foals. Electroencephalography with photic stimulation was performed under standing sedation in 37 JIE foals and 21 controls. Results Abnormalities on EEG were found in 95% of epileptic foals (35 of 37) and in 3 of 21 control asymptomatic foals with affected siblings. Focal ED were detected predominantly in the central vertex with diffusion into the centroparietal or frontocentral regions (n = 35). Generalization of ED occurred in 14 JIE foals. Epileptic discharges commonly were seen during wakefulness (n = 27/37 JIE foals) and sedated sleep (n = 35/37 JIE foals; 3/21 controls). Photic stimulation triggered focal central ED in 15 of 21 JIE foals. Conclusions and Clinical Importance Juvenile idiopathic epilepsy has a focal onset of ED at the central vertex with spread resulting in clinical generalized tonic‐clonic seizures with facial motor activity and loss of consciousness. Electroencephalography with photic stimulation contributes to accurate phenotyping of epilepsy. Foals with this benign self‐limiting disorder might serve as a naturally occurring animal model for self‐limited epilepsy in children. |
| first_indexed | 2024-03-08T12:31:18Z |
| format | Article |
| id | doaj.art-7148cfc089d04c72a39d6ae10f1022c6 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-03-08T12:31:18Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-7148cfc089d04c72a39d6ae10f1022c62024-01-22T02:05:50ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762024-01-0138144945910.1111/jvim.16965Juvenile idiopathic epilepsy in Egyptian Arabian foals, a potential animal model of self‐limited epilepsy in childrenMonica Aleman0Ruba Benini1Sami Elestwani2Tatiana Vinardell3Department of Medicine and Epidemiology, School of Veterinary Medicine University of California Davis California USADivision of Pediatric Neurology, Sidra Medicine Doha QatarDivision of Pediatric Neurology, Sidra Medicine Doha QatarEquine Veterinary Medical Center Doha QatarAbstract Background Juvenile idiopathic epilepsy (JIE) is categorized as a generalized epilepsy. Epilepsy classification entails electrocortical characterization and localization of epileptic discharges (ED) using electroencephalography (EEG). Hypothesis/Objectives Characterize epilepsy in Egyptian Arabian foals with JIE using EEG. Animals Sixty‐nine foals (JIE, 48; controls, 21). Methods Retrospective study. Inclusion criteria consisted of Egyptian Arabian foals: (1) JIE group diagnosed based on witnessed or recorded seizures, and neurological and EEG findings, and (2) control group of healthy nonepileptic age‐matched foals. Clinical data were obtained in 48 foals. Electroencephalography with photic stimulation was performed under standing sedation in 37 JIE foals and 21 controls. Results Abnormalities on EEG were found in 95% of epileptic foals (35 of 37) and in 3 of 21 control asymptomatic foals with affected siblings. Focal ED were detected predominantly in the central vertex with diffusion into the centroparietal or frontocentral regions (n = 35). Generalization of ED occurred in 14 JIE foals. Epileptic discharges commonly were seen during wakefulness (n = 27/37 JIE foals) and sedated sleep (n = 35/37 JIE foals; 3/21 controls). Photic stimulation triggered focal central ED in 15 of 21 JIE foals. Conclusions and Clinical Importance Juvenile idiopathic epilepsy has a focal onset of ED at the central vertex with spread resulting in clinical generalized tonic‐clonic seizures with facial motor activity and loss of consciousness. Electroencephalography with photic stimulation contributes to accurate phenotyping of epilepsy. Foals with this benign self‐limiting disorder might serve as a naturally occurring animal model for self‐limited epilepsy in children.https://doi.org/10.1111/jvim.16965electroencephalogramepilepsyictalparoxysmalphoticseizures |
| spellingShingle | Monica Aleman Ruba Benini Sami Elestwani Tatiana Vinardell Juvenile idiopathic epilepsy in Egyptian Arabian foals, a potential animal model of self‐limited epilepsy in children Journal of Veterinary Internal Medicine electroencephalogram epilepsy ictal paroxysmal photic seizures |
| title | Juvenile idiopathic epilepsy in Egyptian Arabian foals, a potential animal model of self‐limited epilepsy in children |
| title_full | Juvenile idiopathic epilepsy in Egyptian Arabian foals, a potential animal model of self‐limited epilepsy in children |
| title_fullStr | Juvenile idiopathic epilepsy in Egyptian Arabian foals, a potential animal model of self‐limited epilepsy in children |
| title_full_unstemmed | Juvenile idiopathic epilepsy in Egyptian Arabian foals, a potential animal model of self‐limited epilepsy in children |
| title_short | Juvenile idiopathic epilepsy in Egyptian Arabian foals, a potential animal model of self‐limited epilepsy in children |
| title_sort | juvenile idiopathic epilepsy in egyptian arabian foals a potential animal model of self limited epilepsy in children |
| topic | electroencephalogram epilepsy ictal paroxysmal photic seizures |
| url | https://doi.org/10.1111/jvim.16965 |
| work_keys_str_mv | AT monicaaleman juvenileidiopathicepilepsyinegyptianarabianfoalsapotentialanimalmodelofselflimitedepilepsyinchildren AT rubabenini juvenileidiopathicepilepsyinegyptianarabianfoalsapotentialanimalmodelofselflimitedepilepsyinchildren AT samielestwani juvenileidiopathicepilepsyinegyptianarabianfoalsapotentialanimalmodelofselflimitedepilepsyinchildren AT tatianavinardell juvenileidiopathicepilepsyinegyptianarabianfoalsapotentialanimalmodelofselflimitedepilepsyinchildren |