MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
The lack of a unifying metric characterizing combinatorial drug interactions has impeded the development of combinatorial therapies. Here, the authors present MuSyC, a consensus synergy metric that overcomes several caveats associated with other, popular metrics.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24789-z |
| _version_ | 1818841908786495488 |
|---|---|
| author | David J. Wooten Christian T. Meyer Alexander L. R. Lubbock Vito Quaranta Carlos F. Lopez |
| author_facet | David J. Wooten Christian T. Meyer Alexander L. R. Lubbock Vito Quaranta Carlos F. Lopez |
| author_sort | David J. Wooten |
| collection | DOAJ |
| description | The lack of a unifying metric characterizing combinatorial drug interactions has impeded the development of combinatorial therapies. Here, the authors present MuSyC, a consensus synergy metric that overcomes several caveats associated with other, popular metrics. |
| first_indexed | 2024-12-19T04:33:33Z |
| format | Article |
| id | doaj.art-714bcb94521f45b18fccb436c738bfea |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:33:33Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-714bcb94521f45b18fccb436c738bfea2022-12-21T20:35:48ZengNature PortfolioNature Communications2041-17232021-07-0112111610.1038/s41467-021-24789-zMuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discoveryDavid J. Wooten0Christian T. Meyer1Alexander L. R. Lubbock2Vito Quaranta3Carlos F. Lopez4Department of Physics, Pennsylvania State UniversityProgram in Chemical and Physical Biology, Vanderbilt University School of MedicineDepartment of Biochemistry, Vanderbilt University NashvilleDepartment of Biochemistry, Vanderbilt University NashvilleDepartment of Biochemistry, Vanderbilt University NashvilleThe lack of a unifying metric characterizing combinatorial drug interactions has impeded the development of combinatorial therapies. Here, the authors present MuSyC, a consensus synergy metric that overcomes several caveats associated with other, popular metrics.https://doi.org/10.1038/s41467-021-24789-z |
| spellingShingle | David J. Wooten Christian T. Meyer Alexander L. R. Lubbock Vito Quaranta Carlos F. Lopez MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery Nature Communications |
| title | MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery |
| title_full | MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery |
| title_fullStr | MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery |
| title_full_unstemmed | MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery |
| title_short | MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery |
| title_sort | musyc is a consensus framework that unifies multi drug synergy metrics for combinatorial drug discovery |
| url | https://doi.org/10.1038/s41467-021-24789-z |
| work_keys_str_mv | AT davidjwooten musycisaconsensusframeworkthatunifiesmultidrugsynergymetricsforcombinatorialdrugdiscovery AT christiantmeyer musycisaconsensusframeworkthatunifiesmultidrugsynergymetricsforcombinatorialdrugdiscovery AT alexanderlrlubbock musycisaconsensusframeworkthatunifiesmultidrugsynergymetricsforcombinatorialdrugdiscovery AT vitoquaranta musycisaconsensusframeworkthatunifiesmultidrugsynergymetricsforcombinatorialdrugdiscovery AT carlosflopez musycisaconsensusframeworkthatunifiesmultidrugsynergymetricsforcombinatorialdrugdiscovery |