A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1

A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1

The ability to quickly discover reliable hits from screening and rapidly convert them into lead compounds, which can be verified in functional assays, is central to drug discovery. The expedited validation of novel targets and the identification of modulators to advance to preclinical studies can si...

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Bibliographic Details
Main Authors: Debanu Das, Matthew A. J. Duncton, Taxiarchis M. Georgiadis, Patricia Pellicena, Jennifer Clark, Robert W. Sobol, Millie M. Georgiadis, John King-Underwood, David V. Jobes, Caleb Chang, Yang Gao, Ashley M. Deacon, David M. Wilson
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
fragment-based drug discovery
structure-based drug discovery
X-ray crystallography
cancer therapeutics
DNA damage response
polymerases
Online Access:https://www.mdpi.com/1422-0067/24/23/16637

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https://www.mdpi.com/1422-0067/24/23/16637

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