Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms
Dyshomeostasis of vitamin D-binding protein (VDBP) has been implicated in the pathogenesis of various pregnancy complications, including preeclampsia, preterm birth, gestational diabetes, and adverse metabolic profiles in the offspring. VDBP polymorphisms have been consistently reported to contribut...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/1/90 |
| _version_ | 1797498057166684160 |
|---|---|
| author | Spyridon N. Karras Erdinç Dursun Merve Alaylıoglu Duygu Gezen-Ak Fatme Al Anouti Stefan Pilz Pawel Pludowski Edward Jude Kalliopi Kotsa |
| author_facet | Spyridon N. Karras Erdinç Dursun Merve Alaylıoglu Duygu Gezen-Ak Fatme Al Anouti Stefan Pilz Pawel Pludowski Edward Jude Kalliopi Kotsa |
| author_sort | Spyridon N. Karras |
| collection | DOAJ |
| description | Dyshomeostasis of vitamin D-binding protein (VDBP) has been implicated in the pathogenesis of various pregnancy complications, including preeclampsia, preterm birth, gestational diabetes, and adverse metabolic profiles in the offspring. VDBP polymorphisms have been consistently reported to contribute to this intriguing interplay. Until recently, the effects of VDBP polymorphism heterogeneity on maternal and neonatal adipomyokine profiles have not been investigated, specifically after incorporating the different maternal and neonatal 25-hydroxyvitamin D concentration cut-offs at birth. We aimed to investigate the potential effects of maternal and neonatal VDBP polymorphisms on adiponectin, irisin, and VDBP concentrations at birth, according to different cut-offs of vitamin D status, in maternal–neonatal dyads recruited from the sunny region of Northern Greece. We obtained blood samples from 66 mother–child pairs at birth. Results indicated that (i) Neonatal serum biomarkers were not affected by any included neonatal VDBP polymorphism according to different cut-offs of neonatal vitamin D status at birth, (ii) neonatal VDBP concentration was elevated in neonates with maternal rs7041 GG genotype, (iii) maternal 25(OH)D at ≤75 nmol/L resulted in increased concentrations of maternal VBDP and irisin concentrations in women with CC genotype for rs2298850 and rs4588,whereas this effect was also evident for this cut-off for neonatal VDBP concentrations at birth for GC genotype for rs 7041, and (iv) no significant effect of neonatal VDBP polymorphisms was observed on neonatal VDBP, adiponectin, or irisin levels when stratified according to maternal 25(OH)D cut-offs. In conclusion, these findings confirm that among women with the combination of CC genotype for rs2298850 and rs4588, a specific high cut-off of maternal 25(OH)D results in increasing maternal VBDP concentrations, hence providing a mechanistic rationale for aiming for specific cut-offs of vitamin D after supplementation during pregnancy, in daily clinical practice. |
| first_indexed | 2024-03-10T03:27:58Z |
| format | Article |
| id | doaj.art-714ef4b8d8954b469dbb2e4db96f1add |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:27:58Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-714ef4b8d8954b469dbb2e4db96f1add2023-11-23T12:04:02ZengMDPI AGNutrients2072-66432021-12-011419010.3390/nu14010090Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein PolymorphismsSpyridon N. Karras0Erdinç Dursun1Merve Alaylıoglu2Duygu Gezen-Ak3Fatme Al Anouti4Stefan Pilz5Pawel Pludowski6Edward Jude7Kalliopi Kotsa8Division of Endocrinology and Metabolism and Diabetes Center, 1st Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 55535 Thessaloniki, GreeceBrain and Neurodegenerative Disorders Research Laboratories, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34381, TurkeyBrain and Neurodegenerative Disorders Research Laboratories, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34381, TurkeyBrain and Neurodegenerative Disorders Research Laboratories, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34381, TurkeyDepartment of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi 144534, United Arab EmiratesDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, A-8036 Graz, AustriaDepartment of Biochemistry, Radioimmunology and Experimental Medicine, The Children’s Memorial Health Institute, 04730 Warsaw, PolandDepartment of Endocrinology, Tameside Hospital NHS Foundation Trust, Ashton-under-Lyne OL6 9RW, UKDivision of Endocrinology and Metabolism and Diabetes Center, 1st Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 55535 Thessaloniki, GreeceDyshomeostasis of vitamin D-binding protein (VDBP) has been implicated in the pathogenesis of various pregnancy complications, including preeclampsia, preterm birth, gestational diabetes, and adverse metabolic profiles in the offspring. VDBP polymorphisms have been consistently reported to contribute to this intriguing interplay. Until recently, the effects of VDBP polymorphism heterogeneity on maternal and neonatal adipomyokine profiles have not been investigated, specifically after incorporating the different maternal and neonatal 25-hydroxyvitamin D concentration cut-offs at birth. We aimed to investigate the potential effects of maternal and neonatal VDBP polymorphisms on adiponectin, irisin, and VDBP concentrations at birth, according to different cut-offs of vitamin D status, in maternal–neonatal dyads recruited from the sunny region of Northern Greece. We obtained blood samples from 66 mother–child pairs at birth. Results indicated that (i) Neonatal serum biomarkers were not affected by any included neonatal VDBP polymorphism according to different cut-offs of neonatal vitamin D status at birth, (ii) neonatal VDBP concentration was elevated in neonates with maternal rs7041 GG genotype, (iii) maternal 25(OH)D at ≤75 nmol/L resulted in increased concentrations of maternal VBDP and irisin concentrations in women with CC genotype for rs2298850 and rs4588,whereas this effect was also evident for this cut-off for neonatal VDBP concentrations at birth for GC genotype for rs 7041, and (iv) no significant effect of neonatal VDBP polymorphisms was observed on neonatal VDBP, adiponectin, or irisin levels when stratified according to maternal 25(OH)D cut-offs. In conclusion, these findings confirm that among women with the combination of CC genotype for rs2298850 and rs4588, a specific high cut-off of maternal 25(OH)D results in increasing maternal VBDP concentrations, hence providing a mechanistic rationale for aiming for specific cut-offs of vitamin D after supplementation during pregnancy, in daily clinical practice.https://www.mdpi.com/2072-6643/14/1/90vitamin Dpregnancyneonatal healthfunctional polymorphism |
| spellingShingle | Spyridon N. Karras Erdinç Dursun Merve Alaylıoglu Duygu Gezen-Ak Fatme Al Anouti Stefan Pilz Pawel Pludowski Edward Jude Kalliopi Kotsa Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms Nutrients vitamin D pregnancy neonatal health functional polymorphism |
| title | Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms |
| title_full | Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms |
| title_fullStr | Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms |
| title_full_unstemmed | Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms |
| title_short | Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms |
| title_sort | upregulation of irisin and vitamin d binding protein concentrations by increasing maternal 25 hydrovitamin d concentrations in combination with specific genotypes of vitamin d binding protein polymorphisms |
| topic | vitamin D pregnancy neonatal health functional polymorphism |
| url | https://www.mdpi.com/2072-6643/14/1/90 |
| work_keys_str_mv | AT spyridonnkarras upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms AT erdincdursun upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms AT mervealaylıoglu upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms AT duygugezenak upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms AT fatmealanouti upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms AT stefanpilz upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms AT pawelpludowski upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms AT edwardjude upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms AT kalliopikotsa upregulationofirisinandvitamindbindingproteinconcentrationsbyincreasingmaternal25hydrovitamindconcentrationsincombinationwithspecificgenotypesofvitamindbindingproteinpolymorphisms |