Determining the Diagnostic Accuracy of Non-Contrast High-Resolution Computed Tomography Chest Study in COVID-19 Pneumonia Keeping PCR Assay as Gold Standard
Objective: To determine the diagnostic accuracy of high-resolution computed tomography (HRCT) chest in determination of corona virus disease (COVID-19) taking polymerase chain reaction (PCR) as gold standard. Methods: This diagnostic cross-sectional study was conducted at Shifa International Hospi...
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| Format: | Article |
| Language: | English |
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Dow University of Health Sciences
2020-12-01
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| Series: | Journal of the Dow University of Health Sciences |
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| Online Access: | https://jduhs.com/index.php/jduhs/article/view/1021 |
| _version_ | 1797810644063354880 |
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| author | Maria Rauf Sanam Yasir Raana Kanwa Belqees Yawar Faiz Atif Iqbal Rana Salma Gul Rohama Saeed |
| author_facet | Maria Rauf Sanam Yasir Raana Kanwa Belqees Yawar Faiz Atif Iqbal Rana Salma Gul Rohama Saeed |
| author_sort | Maria Rauf |
| collection | DOAJ |
| description | Objective: To determine the diagnostic accuracy of high-resolution computed tomography (HRCT) chest in determination of corona virus disease (COVID-19) taking polymerase chain reaction (PCR) as gold standard.
Methods: This diagnostic cross-sectional study was conducted at Shifa International Hospital Islamabad (SIH) from February 2020 to April 2020. All patients suspected for COVID 19 pneumonia were consecutively enrolled. Diagnosis was done via both HRCT chest and PCR assay. Patient s demographic characteristics and PCR results were retrieved from hospital database. Diagnostic accuracy was explored by calculating sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall diagnostic accuracy.
Results: Of 250 patients, the mean age was 58.5 years +- 14.7 years. HRCT findings in positive scans showed that of 181 patients, majority of the patients presented with multifocal peripheral rounded ground glass opacities (GGOs) with crazy paving observed in 77 (42.5%), multifocal peripheral rounded in GGOs 51 (28.1%), and multifocal peripheral rounded GGOs with crazy paving and consolidations 45 (24.8%). Furthermore, bilateral lungs and multifocal multilobar involvement of lungs was observed in 179 (98.8%) each. While peripheral lung involvement was observed in 176 (97.2%) patients. The sensitivity, specificity, PPV, NPV, and overall diagnostic accuracy of HRCT chest in diagnosing COVID-19 pneumonia was 93.4%, 53.5%, 71.2%, 86.9%, and 75.6% respectively.
Conclusion: HRCT chest has a higher sensitivity and comparable diagnostic accuracy to PCR testing in diagnosing COVID 19 pneumonia and thus in the epidemic areas, it can be used as an important adjunct to PCR testing.
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| first_indexed | 2024-03-13T07:10:53Z |
| format | Article |
| id | doaj.art-715144d99ced4003b6f4e6041b1bef47 |
| institution | Directory Open Access Journal |
| issn | 1995-2198 2410-2180 |
| language | English |
| last_indexed | 2024-03-13T07:10:53Z |
| publishDate | 2020-12-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj.art-715144d99ced4003b6f4e6041b1bef472023-06-06T03:12:16ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802020-12-0114310.36570/jduhs.2020.3.1021Determining the Diagnostic Accuracy of Non-Contrast High-Resolution Computed Tomography Chest Study in COVID-19 Pneumonia Keeping PCR Assay as Gold StandardMaria Rauf0Sanam Yasir1Raana Kanwa2Belqees Yawar Faiz3Atif Iqbal Rana4Salma Gul5Rohama Saeed6Department of Radiology, Shifa International Hospital Islamabad, Pakistan.Department of Radiology, Shifa International Hospital Islamabad, Pakistan.Department of Radiology, Shifa International Hospital Islamabad, Pakistan.Department of Radiology, Shifa International Hospital Islamabad, Pakistan.Department of Radiology, Shifa International Hospital Islamabad, PakistanDepartment of Radiology, Shifa International Hospital Islamabad, Pakistan.Department of Radiology, Shifa International Hospital Islamabad, Pakistan.Objective: To determine the diagnostic accuracy of high-resolution computed tomography (HRCT) chest in determination of corona virus disease (COVID-19) taking polymerase chain reaction (PCR) as gold standard. Methods: This diagnostic cross-sectional study was conducted at Shifa International Hospital Islamabad (SIH) from February 2020 to April 2020. All patients suspected for COVID 19 pneumonia were consecutively enrolled. Diagnosis was done via both HRCT chest and PCR assay. Patient s demographic characteristics and PCR results were retrieved from hospital database. Diagnostic accuracy was explored by calculating sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall diagnostic accuracy. Results: Of 250 patients, the mean age was 58.5 years +- 14.7 years. HRCT findings in positive scans showed that of 181 patients, majority of the patients presented with multifocal peripheral rounded ground glass opacities (GGOs) with crazy paving observed in 77 (42.5%), multifocal peripheral rounded in GGOs 51 (28.1%), and multifocal peripheral rounded GGOs with crazy paving and consolidations 45 (24.8%). Furthermore, bilateral lungs and multifocal multilobar involvement of lungs was observed in 179 (98.8%) each. While peripheral lung involvement was observed in 176 (97.2%) patients. The sensitivity, specificity, PPV, NPV, and overall diagnostic accuracy of HRCT chest in diagnosing COVID-19 pneumonia was 93.4%, 53.5%, 71.2%, 86.9%, and 75.6% respectively. Conclusion: HRCT chest has a higher sensitivity and comparable diagnostic accuracy to PCR testing in diagnosing COVID 19 pneumonia and thus in the epidemic areas, it can be used as an important adjunct to PCR testing. https://jduhs.com/index.php/jduhs/article/view/1021Diagnostic accuracyHRCT chestPCRsensitivityspecificity |
| spellingShingle | Maria Rauf Sanam Yasir Raana Kanwa Belqees Yawar Faiz Atif Iqbal Rana Salma Gul Rohama Saeed Determining the Diagnostic Accuracy of Non-Contrast High-Resolution Computed Tomography Chest Study in COVID-19 Pneumonia Keeping PCR Assay as Gold Standard Journal of the Dow University of Health Sciences Diagnostic accuracy HRCT chest PCR sensitivity specificity |
| title | Determining the Diagnostic Accuracy of Non-Contrast High-Resolution Computed Tomography Chest Study in COVID-19 Pneumonia Keeping PCR Assay as Gold Standard |
| title_full | Determining the Diagnostic Accuracy of Non-Contrast High-Resolution Computed Tomography Chest Study in COVID-19 Pneumonia Keeping PCR Assay as Gold Standard |
| title_fullStr | Determining the Diagnostic Accuracy of Non-Contrast High-Resolution Computed Tomography Chest Study in COVID-19 Pneumonia Keeping PCR Assay as Gold Standard |
| title_full_unstemmed | Determining the Diagnostic Accuracy of Non-Contrast High-Resolution Computed Tomography Chest Study in COVID-19 Pneumonia Keeping PCR Assay as Gold Standard |
| title_short | Determining the Diagnostic Accuracy of Non-Contrast High-Resolution Computed Tomography Chest Study in COVID-19 Pneumonia Keeping PCR Assay as Gold Standard |
| title_sort | determining the diagnostic accuracy of non contrast high resolution computed tomography chest study in covid 19 pneumonia keeping pcr assay as gold standard |
| topic | Diagnostic accuracy HRCT chest PCR sensitivity specificity |
| url | https://jduhs.com/index.php/jduhs/article/view/1021 |
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