Impact of tumor architecture on disease recurrence and cancer-specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomy
Upper tract urinary carcinoma (UTUC) is a relatively uncommon but aggressive disease. Recent publications have assessed the prognostic significance of tumor architecture in UTUC, but there is still controversy regarding the significance and importance of tumor architecture on disease recurrence. We...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IOS Press
2017-07-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317710822 |
| _version_ | 1819121669869928448 |
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| author | Bo Fan Bin Hu Qingmin Yuan Shuang Wen Tianqing Liu Shanshan Bai Xiaofeng Qi Xin Wang Deyong Yang Xiuzhen Sun Xishuang Song |
| author_facet | Bo Fan Bin Hu Qingmin Yuan Shuang Wen Tianqing Liu Shanshan Bai Xiaofeng Qi Xin Wang Deyong Yang Xiuzhen Sun Xishuang Song |
| author_sort | Bo Fan |
| collection | DOAJ |
| description | Upper tract urinary carcinoma (UTUC) is a relatively uncommon but aggressive disease. Recent publications have assessed the prognostic significance of tumor architecture in UTUC, but there is still controversy regarding the significance and importance of tumor architecture on disease recurrence. We retrospectively reviewed the medical records of 101 patients with clinical UTUC who had undergone surgery. Univariate and multivariate analyses were conducted to identify factors associated with disease recurrence and cancer-specific mortality. As our single center study and the limited sample size may influence the clinical significance, we further quantitatively combined the results with those of existing published literature through a meta-analysis compiled from searching several databases. At a median follow-up of 41.3 months, 25 patients experienced disease recurrence. Spearman’s correlation analysis showed that tumor architecture was found to be positively correlated with the tumor location and the histological grade. Kaplan-Meier curves showed that patients with sessile tumor architecture had significantly poor recurrence free survival (RFS) and cancer specific survival (CSS). Furthermore, multivariate analysis suggested that tumor architecture was independent prognostic factors for RFS (Hazard ratio, HR = 2.648) and CSS (HR = 2.072) in UTUC patients. A meta-analysis of investigating tumor architecture and its effects on UTUC prognosis was conducted. After searching PubMed, Medline, Embase, Cochrane Library and Scopus databases, 17 articles met the eligibility criteria for this analysis. The eligible studies included a total of 14,368 patients and combined results showed that sessile tumor architecture was associated with both disease recurrence with a pooled HR estimate of 1.454 and cancer-specific mortality with a pooled HR estimate of 1.416. Tumor architecture is an independent predictor for disease recurrence after radical nephroureterectomy for UTUC. Therefore, closer surveillance is necessary, especially in patients with sessile tumor architecture. |
| first_indexed | 2024-12-22T06:40:14Z |
| format | Article |
| id | doaj.art-7152a3a31f814288b1d862ccdfee613f |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-22T06:40:14Z |
| publishDate | 2017-07-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-7152a3a31f814288b1d862ccdfee613f2022-12-21T18:35:27ZengIOS PressTumor Biology1423-03802017-07-013910.1177/1010428317710822Impact of tumor architecture on disease recurrence and cancer-specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomyBo Fan0Bin Hu1Qingmin Yuan2Shuang Wen3Tianqing Liu4Shanshan Bai5Xiaofeng Qi6Xin Wang7Deyong Yang8Xiuzhen Sun9Xishuang Song10Graduate School, Dalian Medical University, Dalian, P.R. ChinaDepartment of Urology, Liaoning Cancer Hospital and Institute, Shenyang, P.R. ChinaGraduate School, Dalian Medical University, Dalian, P.R. ChinaDepartment of Pathology, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, P.R. ChinaDepartment of Pathology, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, P.R. ChinaDepartment of Ultrasonography, First Affiliated Hospital of Dalian Medical University, Dalian, P.R. ChinaGraduate School, Dalian Medical University, Dalian, P.R. ChinaGraduate School, Dalian Medical University, Dalian, P.R. ChinaDepartment of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, P.R. ChinaDepartment of Otorhinolaryngology, Second Hospital of Dalian Medical University, Dalian, P.R. ChinaDepartment of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, P.R. ChinaUpper tract urinary carcinoma (UTUC) is a relatively uncommon but aggressive disease. Recent publications have assessed the prognostic significance of tumor architecture in UTUC, but there is still controversy regarding the significance and importance of tumor architecture on disease recurrence. We retrospectively reviewed the medical records of 101 patients with clinical UTUC who had undergone surgery. Univariate and multivariate analyses were conducted to identify factors associated with disease recurrence and cancer-specific mortality. As our single center study and the limited sample size may influence the clinical significance, we further quantitatively combined the results with those of existing published literature through a meta-analysis compiled from searching several databases. At a median follow-up of 41.3 months, 25 patients experienced disease recurrence. Spearman’s correlation analysis showed that tumor architecture was found to be positively correlated with the tumor location and the histological grade. Kaplan-Meier curves showed that patients with sessile tumor architecture had significantly poor recurrence free survival (RFS) and cancer specific survival (CSS). Furthermore, multivariate analysis suggested that tumor architecture was independent prognostic factors for RFS (Hazard ratio, HR = 2.648) and CSS (HR = 2.072) in UTUC patients. A meta-analysis of investigating tumor architecture and its effects on UTUC prognosis was conducted. After searching PubMed, Medline, Embase, Cochrane Library and Scopus databases, 17 articles met the eligibility criteria for this analysis. The eligible studies included a total of 14,368 patients and combined results showed that sessile tumor architecture was associated with both disease recurrence with a pooled HR estimate of 1.454 and cancer-specific mortality with a pooled HR estimate of 1.416. Tumor architecture is an independent predictor for disease recurrence after radical nephroureterectomy for UTUC. Therefore, closer surveillance is necessary, especially in patients with sessile tumor architecture.https://doi.org/10.1177/1010428317710822 |
| spellingShingle | Bo Fan Bin Hu Qingmin Yuan Shuang Wen Tianqing Liu Shanshan Bai Xiaofeng Qi Xin Wang Deyong Yang Xiuzhen Sun Xishuang Song Impact of tumor architecture on disease recurrence and cancer-specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomy Tumor Biology |
| title | Impact of tumor architecture on disease recurrence and cancer-specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomy |
| title_full | Impact of tumor architecture on disease recurrence and cancer-specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomy |
| title_fullStr | Impact of tumor architecture on disease recurrence and cancer-specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomy |
| title_full_unstemmed | Impact of tumor architecture on disease recurrence and cancer-specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomy |
| title_short | Impact of tumor architecture on disease recurrence and cancer-specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomy |
| title_sort | impact of tumor architecture on disease recurrence and cancer specific mortality of upper tract urothelial carcinoma treated with radical nephroureterectomy |
| url | https://doi.org/10.1177/1010428317710822 |
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