Aqueous extract of <it>Piper sarmentosum </it>decreases atherosclerotic lesions in high cholesterolemic experimental rabbits
<p>Abstract</p> <p>Background</p> <p><it>Piper sarmentosum </it>(P.s) has flavonoid component in its leaves which has antioxidative effect. To date, its effect on atherosclerosis has not been studied histologically.</p> <p>Aim</p> <p>...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-04-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/9/1/44 |
| _version_ | 1811252760711004160 |
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| author | Raj Santhana Das Srijit Othman Faizah Zakaria Zaiton Amran Adel A Nordin Nor-Anita MM |
| author_facet | Raj Santhana Das Srijit Othman Faizah Zakaria Zaiton Amran Adel A Nordin Nor-Anita MM |
| author_sort | Raj Santhana |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Piper sarmentosum </it>(P.s) has flavonoid component in its leaves which has antioxidative effect. To date, its effect on atherosclerosis has not been studied histologically.</p> <p>Aim</p> <p>The study aimed to investigate the effect of <it>P.s </it>on atherosclerotic changes in hypercholesterolemic rabbits.</p> <p>Methods</p> <p>Forty two male New Zealand white rabbits were divided into seven groups. C - control group fed normal rabbit chow, CH - cholesterol diet (1% cholesterol), W1 - 1% cholesterol with water extract of <it>P.s </it>(62.5 mg/kg), W2 - 1% cholesterol with water extract of <it>P.s </it>(125 mg/kg), W3 - 1% cholesterol with water extract of <it>P.s </it>(250 mg/kg), W4 - 1% cholesterol with water extract of <it>P.s </it>(500 mg/kg) and Smv - 1% cholesterol supplemented with simvistatin drug (1.2 mg/kg). All rabbits were treated for 10 weeks. Following 10 weeks of supplementation, the animals were sacrificed and the aortic tissue was taken for histological study.</p> <p>Results</p> <p>Rabbits fed only with high cholesterol diet 1% cholesterol (CH) showed focal fatty streak lesions compared to the C group and 1% cholesterol supplemented with simvistatin drug (Smv) group. Atherosclerotic lesions in the 1% cholesterol group supplemented with <it>P.s </it>(500 mg/kg) i.e. W4 group showed significant reduction (30 ± 6.0%, p < 0.05) in fatty streak compared to the high cholesterol group (85.6 ± 4.1%) under Sudan IV stain. The atherosclerotic lesions under transmission electron microscope showed reduction in foam cells in the treatment groups compared to the CH groups.</p> <p>Conclusion</p> <p>Administration of <it>P.s </it>extract has protective effect against atheroscleros</p> |
| first_indexed | 2024-04-12T16:39:23Z |
| format | Article |
| id | doaj.art-7152cc284f654c8a9ef5a59788f29fdb |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-12T16:39:23Z |
| publishDate | 2010-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-7152cc284f654c8a9ef5a59788f29fdb2022-12-22T03:24:51ZengBMCLipids in Health and Disease1476-511X2010-04-01914410.1186/1476-511X-9-44Aqueous extract of <it>Piper sarmentosum </it>decreases atherosclerotic lesions in high cholesterolemic experimental rabbitsRaj SanthanaDas SrijitOthman FaizahZakaria ZaitonAmran Adel ANordin Nor-Anita MM<p>Abstract</p> <p>Background</p> <p><it>Piper sarmentosum </it>(P.s) has flavonoid component in its leaves which has antioxidative effect. To date, its effect on atherosclerosis has not been studied histologically.</p> <p>Aim</p> <p>The study aimed to investigate the effect of <it>P.s </it>on atherosclerotic changes in hypercholesterolemic rabbits.</p> <p>Methods</p> <p>Forty two male New Zealand white rabbits were divided into seven groups. C - control group fed normal rabbit chow, CH - cholesterol diet (1% cholesterol), W1 - 1% cholesterol with water extract of <it>P.s </it>(62.5 mg/kg), W2 - 1% cholesterol with water extract of <it>P.s </it>(125 mg/kg), W3 - 1% cholesterol with water extract of <it>P.s </it>(250 mg/kg), W4 - 1% cholesterol with water extract of <it>P.s </it>(500 mg/kg) and Smv - 1% cholesterol supplemented with simvistatin drug (1.2 mg/kg). All rabbits were treated for 10 weeks. Following 10 weeks of supplementation, the animals were sacrificed and the aortic tissue was taken for histological study.</p> <p>Results</p> <p>Rabbits fed only with high cholesterol diet 1% cholesterol (CH) showed focal fatty streak lesions compared to the C group and 1% cholesterol supplemented with simvistatin drug (Smv) group. Atherosclerotic lesions in the 1% cholesterol group supplemented with <it>P.s </it>(500 mg/kg) i.e. W4 group showed significant reduction (30 ± 6.0%, p < 0.05) in fatty streak compared to the high cholesterol group (85.6 ± 4.1%) under Sudan IV stain. The atherosclerotic lesions under transmission electron microscope showed reduction in foam cells in the treatment groups compared to the CH groups.</p> <p>Conclusion</p> <p>Administration of <it>P.s </it>extract has protective effect against atheroscleros</p>http://www.lipidworld.com/content/9/1/44 |
| spellingShingle | Raj Santhana Das Srijit Othman Faizah Zakaria Zaiton Amran Adel A Nordin Nor-Anita MM Aqueous extract of <it>Piper sarmentosum </it>decreases atherosclerotic lesions in high cholesterolemic experimental rabbits Lipids in Health and Disease |
| title | Aqueous extract of <it>Piper sarmentosum </it>decreases atherosclerotic lesions in high cholesterolemic experimental rabbits |
| title_full | Aqueous extract of <it>Piper sarmentosum </it>decreases atherosclerotic lesions in high cholesterolemic experimental rabbits |
| title_fullStr | Aqueous extract of <it>Piper sarmentosum </it>decreases atherosclerotic lesions in high cholesterolemic experimental rabbits |
| title_full_unstemmed | Aqueous extract of <it>Piper sarmentosum </it>decreases atherosclerotic lesions in high cholesterolemic experimental rabbits |
| title_short | Aqueous extract of <it>Piper sarmentosum </it>decreases atherosclerotic lesions in high cholesterolemic experimental rabbits |
| title_sort | aqueous extract of it piper sarmentosum it decreases atherosclerotic lesions in high cholesterolemic experimental rabbits |
| url | http://www.lipidworld.com/content/9/1/44 |
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